Experimental Models of Cognitive Impairment for Use in Parkinson’s Disease Research: The Distance Between Reality and Ideal

Parkinson’s disease (PD) is the second most common neurodegenerative disease. Cognitive impairment is one of the key non-motor symptoms of PD, affecting both mortality and quality of life. However, there are few experimental studies on the pathology and treatments of PD with mild cognitive impairmen...

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Autores principales:	Yaohua Fan, Jiajun Han, Lijun Zhao, Chunxiao Wu, Peipei Wu, Zifeng Huang, Xiaoqian Hao, YiChun Ji, Dongfeng Chen, Meiling Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Parkinson’s disease cognitive impairment experimental model toxins transgenic animal limitations Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/5cad1efb369746f1b47fa997bcc7b0ac
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spelling	oai:doaj.org-article:5cad1efb369746f1b47fa997bcc7b0ac2021-12-01T13:21:12ZExperimental Models of Cognitive Impairment for Use in Parkinson’s Disease Research: The Distance Between Reality and Ideal1663-436510.3389/fnagi.2021.745438https://doaj.org/article/5cad1efb369746f1b47fa997bcc7b0ac2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.745438/fullhttps://doaj.org/toc/1663-4365Parkinson’s disease (PD) is the second most common neurodegenerative disease. Cognitive impairment is one of the key non-motor symptoms of PD, affecting both mortality and quality of life. However, there are few experimental studies on the pathology and treatments of PD with mild cognitive impairment (PD-MCI) and PD dementia (PDD) due to the lack of representative models. To identify new strategies for developing representative models, we systematically summarized previous studies on PD-MCI and PDD and compared differences between existing models and diseases. Our initial search identified 5432 articles, of which 738 were duplicates. A total of 227 articles met our inclusion criteria and were included in the analysis. Models fell into three categories based on model design: neurotoxin-induced, transgenic, and combined. Although the neurotoxin-induced experimental model was the most common type that was used during every time period, transgenic and combined experimental models have gained significant recent attention. Unfortunately, there remains a big gap between ideal and actual experimental models. While each model has its own disadvantages, there have been tremendous advances in the development of PD models of cognitive impairment, and almost every model can verify a hypothesis about PD-MCI or PDD. Finally, our proposed strategies for developing novel models are as follows: a set of plans that integrate symptoms, biochemistry, neuroimaging, and other objective indicators to judge and identify that the novel model plays a key role in new strategies for developing representative models; novel models should simulate different clinical features of PD-MCI or PDD; inducible α-Syn overexpression and SH-SY5Y-A53T cellular models are good candidate models of PD-MCI or PDD.Yaohua FanJiajun HanLijun ZhaoChunxiao WuChunxiao WuPeipei WuZifeng HuangXiaoqian HaoYiChun JiDongfeng ChenMeiling ZhuFrontiers Media S.A.articleParkinson’s diseasecognitive impairmentexperimental modeltoxinstransgenic animallimitationsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parkinson’s disease cognitive impairment experimental model toxins transgenic animal limitations Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Parkinson’s disease cognitive impairment experimental model toxins transgenic animal limitations Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Yaohua Fan Jiajun Han Lijun Zhao Chunxiao Wu Chunxiao Wu Peipei Wu Zifeng Huang Xiaoqian Hao YiChun Ji Dongfeng Chen Meiling Zhu Experimental Models of Cognitive Impairment for Use in Parkinson’s Disease Research: The Distance Between Reality and Ideal
description	Parkinson’s disease (PD) is the second most common neurodegenerative disease. Cognitive impairment is one of the key non-motor symptoms of PD, affecting both mortality and quality of life. However, there are few experimental studies on the pathology and treatments of PD with mild cognitive impairment (PD-MCI) and PD dementia (PDD) due to the lack of representative models. To identify new strategies for developing representative models, we systematically summarized previous studies on PD-MCI and PDD and compared differences between existing models and diseases. Our initial search identified 5432 articles, of which 738 were duplicates. A total of 227 articles met our inclusion criteria and were included in the analysis. Models fell into three categories based on model design: neurotoxin-induced, transgenic, and combined. Although the neurotoxin-induced experimental model was the most common type that was used during every time period, transgenic and combined experimental models have gained significant recent attention. Unfortunately, there remains a big gap between ideal and actual experimental models. While each model has its own disadvantages, there have been tremendous advances in the development of PD models of cognitive impairment, and almost every model can verify a hypothesis about PD-MCI or PDD. Finally, our proposed strategies for developing novel models are as follows: a set of plans that integrate symptoms, biochemistry, neuroimaging, and other objective indicators to judge and identify that the novel model plays a key role in new strategies for developing representative models; novel models should simulate different clinical features of PD-MCI or PDD; inducible α-Syn overexpression and SH-SY5Y-A53T cellular models are good candidate models of PD-MCI or PDD.
format	article
author	Yaohua Fan Jiajun Han Lijun Zhao Chunxiao Wu Chunxiao Wu Peipei Wu Zifeng Huang Xiaoqian Hao YiChun Ji Dongfeng Chen Meiling Zhu
author_facet	Yaohua Fan Jiajun Han Lijun Zhao Chunxiao Wu Chunxiao Wu Peipei Wu Zifeng Huang Xiaoqian Hao YiChun Ji Dongfeng Chen Meiling Zhu
author_sort	Yaohua Fan
title	Experimental Models of Cognitive Impairment for Use in Parkinson’s Disease Research: The Distance Between Reality and Ideal
title_short	Experimental Models of Cognitive Impairment for Use in Parkinson’s Disease Research: The Distance Between Reality and Ideal
title_full	Experimental Models of Cognitive Impairment for Use in Parkinson’s Disease Research: The Distance Between Reality and Ideal
title_fullStr	Experimental Models of Cognitive Impairment for Use in Parkinson’s Disease Research: The Distance Between Reality and Ideal
title_full_unstemmed	Experimental Models of Cognitive Impairment for Use in Parkinson’s Disease Research: The Distance Between Reality and Ideal
title_sort	experimental models of cognitive impairment for use in parkinson’s disease research: the distance between reality and ideal
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5cad1efb369746f1b47fa997bcc7b0ac
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Experimental Models of Cognitive Impairment for Use in Parkinson’s Disease Research: The Distance Between Reality and Ideal

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