Role of C-Reactive Protein in Discrimination between Transudative and Exudative Pleural Effusions

Background: There is still no wide agreement regarding the efficacy of the serum levels of C-reactive protein (CRPs), pleural fluid levels of CRP (CRPpf), and their ratio (CRPr) in the discrimination between transudative (Tr) and exudative (Ex) pleural effusions (PEs). Most of the previous studies w...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yana Kogan, Edmond Sabo, Majed Odeh
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	C-reactive protein pleural effusion transudate exudate Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5caeefc6e1d94eb8a57e19adf3cb2561
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5caeefc6e1d94eb8a57e19adf3cb2561
record_format	dspace
spelling	oai:doaj.org-article:5caeefc6e1d94eb8a57e19adf3cb25612021-11-25T17:20:39ZRole of C-Reactive Protein in Discrimination between Transudative and Exudative Pleural Effusions10.3390/diagnostics111120032075-4418https://doaj.org/article/5caeefc6e1d94eb8a57e19adf3cb25612021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2003https://doaj.org/toc/2075-4418Background: There is still no wide agreement regarding the efficacy of the serum levels of C-reactive protein (CRPs), pleural fluid levels of CRP (CRPpf), and their ratio (CRPr) in the discrimination between transudative (Tr) and exudative (Ex) pleural effusions (PEs). Most of the previous studies were conducted on small cohorts, and the role of CRPs in the CRPpf gradient (CRPg) in this discrimination has not been previously reported. The present study aims to assess the diagnostic efficacy of CRPs, CRPpf, CRPg, and CRPr in the discrimination between TrPE and ExPE in a relatively large cohort of patients with PE. Methods: The study population included 492 patients with PE, 210 of them with TrPE and 282 with ExPE. The levels of CRPs and CRPpf were measured, and the CRPg and CRPr were calculated. The values are presented as mean ± SD. Results: The mean levels of CRPs, CRPpf, CRPg, and CRPr of the TrPEs were 11.3 ± 5.7 mg/L, 4.6 ± 2.8 mg/L, 6.7 ± 3.9 mg/L, and 0.40 ± 0.14, respectively, and for the ExPEs, they were 140.5 ± 112.8 mg/L, 52.8 ± 53.2 mg/L, 87.2 ± 72.4 mg/L, and 0.37 ± 0.15, respectively. The levels of CRPs, CRPpf, and CRPg were significantly higher in the ExPEs than in the TrPEs (<i>p</i> < 0.0001). No significant difference was found between the two groups for the levels of CRPr (<i>p</i> = 0.15). The best cut-off value calculated by the receiver operating characteristic (ROC) analysis for discriminating TrPE from ExPE was for CRPs, 20.5 mg/L with area under the curve (AUC) = 97% and <i>p</i> < 0.0001; for CRPpf, 9.9 mg/L with AUC = 95% and <i>p</i> < 0.0001; and for CRPg, 13.6 mg/L with AUC = 96% and <i>p</i> < 0.0001. Conclusion: CRPs, CRPpf, and CRPg are strong markers for discrimination between TrPE and ExPE, while CRPr has no role in this discrimination.Yana KoganEdmond SaboMajed OdehMDPI AGarticleC-reactive proteinpleural effusiontransudateexudateMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2003, p 2003 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	C-reactive protein pleural effusion transudate exudate Medicine (General) R5-920
spellingShingle	C-reactive protein pleural effusion transudate exudate Medicine (General) R5-920 Yana Kogan Edmond Sabo Majed Odeh Role of C-Reactive Protein in Discrimination between Transudative and Exudative Pleural Effusions
description	Background: There is still no wide agreement regarding the efficacy of the serum levels of C-reactive protein (CRPs), pleural fluid levels of CRP (CRPpf), and their ratio (CRPr) in the discrimination between transudative (Tr) and exudative (Ex) pleural effusions (PEs). Most of the previous studies were conducted on small cohorts, and the role of CRPs in the CRPpf gradient (CRPg) in this discrimination has not been previously reported. The present study aims to assess the diagnostic efficacy of CRPs, CRPpf, CRPg, and CRPr in the discrimination between TrPE and ExPE in a relatively large cohort of patients with PE. Methods: The study population included 492 patients with PE, 210 of them with TrPE and 282 with ExPE. The levels of CRPs and CRPpf were measured, and the CRPg and CRPr were calculated. The values are presented as mean ± SD. Results: The mean levels of CRPs, CRPpf, CRPg, and CRPr of the TrPEs were 11.3 ± 5.7 mg/L, 4.6 ± 2.8 mg/L, 6.7 ± 3.9 mg/L, and 0.40 ± 0.14, respectively, and for the ExPEs, they were 140.5 ± 112.8 mg/L, 52.8 ± 53.2 mg/L, 87.2 ± 72.4 mg/L, and 0.37 ± 0.15, respectively. The levels of CRPs, CRPpf, and CRPg were significantly higher in the ExPEs than in the TrPEs (<i>p</i> < 0.0001). No significant difference was found between the two groups for the levels of CRPr (<i>p</i> = 0.15). The best cut-off value calculated by the receiver operating characteristic (ROC) analysis for discriminating TrPE from ExPE was for CRPs, 20.5 mg/L with area under the curve (AUC) = 97% and <i>p</i> < 0.0001; for CRPpf, 9.9 mg/L with AUC = 95% and <i>p</i> < 0.0001; and for CRPg, 13.6 mg/L with AUC = 96% and <i>p</i> < 0.0001. Conclusion: CRPs, CRPpf, and CRPg are strong markers for discrimination between TrPE and ExPE, while CRPr has no role in this discrimination.
format	article
author	Yana Kogan Edmond Sabo Majed Odeh
author_facet	Yana Kogan Edmond Sabo Majed Odeh
author_sort	Yana Kogan
title	Role of C-Reactive Protein in Discrimination between Transudative and Exudative Pleural Effusions
title_short	Role of C-Reactive Protein in Discrimination between Transudative and Exudative Pleural Effusions
title_full	Role of C-Reactive Protein in Discrimination between Transudative and Exudative Pleural Effusions
title_fullStr	Role of C-Reactive Protein in Discrimination between Transudative and Exudative Pleural Effusions
title_full_unstemmed	Role of C-Reactive Protein in Discrimination between Transudative and Exudative Pleural Effusions
title_sort	role of c-reactive protein in discrimination between transudative and exudative pleural effusions
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5caeefc6e1d94eb8a57e19adf3cb2561
work_keys_str_mv	AT yanakogan roleofcreactiveproteinindiscriminationbetweentransudativeandexudativepleuraleffusions AT edmondsabo roleofcreactiveproteinindiscriminationbetweentransudativeandexudativepleuraleffusions AT majedodeh roleofcreactiveproteinindiscriminationbetweentransudativeandexudativepleuraleffusions
_version_	1718412472990302208

Role of C-Reactive Protein in Discrimination between Transudative and Exudative Pleural Effusions

Ejemplares similares