New treatment options in the management of fibromyalgia: role of pregabalin

Grazyna ZarebaDepartment of Environmental Medicine, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USAAbstract: Fibromyalgia (FM) is a common, chronic pain disorder with unknown etiology, characterized by widespread musculoskeletal pain and tenderness, and accompanied by s...

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Autor principal:	Grazyna Zareba
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5cb11c0d9c6942f8ad092d5545ad1fd6
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spelling	oai:doaj.org-article:5cb11c0d9c6942f8ad092d5545ad1fd62021-12-02T01:23:35ZNew treatment options in the management of fibromyalgia: role of pregabalin1176-63281178-2021https://doaj.org/article/5cb11c0d9c6942f8ad092d5545ad1fd62008-09-01T00:00:00Zhttp://www.dovepress.com/new-treatment-options-in-the-management-of-fibromyalgia-role-of-pregab-a2272https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Grazyna ZarebaDepartment of Environmental Medicine, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USAAbstract: Fibromyalgia (FM) is a common, chronic pain disorder with unknown etiology, characterized by widespread musculoskeletal pain and tenderness, and accompanied by several other symptoms such as sleep disturbance, fatigue, and mood disorders. Pregabalin is the first drug approved for the treatment of FM. Pregabalin has analgesic, anticonvulsant, and anxiolytic activity and has earlier demonstrated efficacy in the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, and as adjuvant therapy for adult patients with partial onset seizures. Pregabalin, a lipophilic gamma-aminobutyric acid (GABA) analog, is &alpha;2&delta;-1 ligand that binds to, and modulates, voltage-gated calcium channels. This modulation is characterized by a reduction of the excessive neurotransmitter release that is observed in certain neurological and psychotic disorders. Several randomized, double-blind, placebo-controlled studies have demonstrated that pregabalin has been effective in pain management, improving sleep quality and fatigue, as well as in several domains of health related quality of life. Because of mild to moderate adverse effects it can be considered a well-tolerated therapy for FM.Keywords: fibromyalgia, pregabalin, GABA analog, fibromyalgia treatment Grazyna ZarebaDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 6, Pp 1193-1201 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Grazyna Zareba New treatment options in the management of fibromyalgia: role of pregabalin
description	Grazyna ZarebaDepartment of Environmental Medicine, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USAAbstract: Fibromyalgia (FM) is a common, chronic pain disorder with unknown etiology, characterized by widespread musculoskeletal pain and tenderness, and accompanied by several other symptoms such as sleep disturbance, fatigue, and mood disorders. Pregabalin is the first drug approved for the treatment of FM. Pregabalin has analgesic, anticonvulsant, and anxiolytic activity and has earlier demonstrated efficacy in the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, and as adjuvant therapy for adult patients with partial onset seizures. Pregabalin, a lipophilic gamma-aminobutyric acid (GABA) analog, is &alpha;2&delta;-1 ligand that binds to, and modulates, voltage-gated calcium channels. This modulation is characterized by a reduction of the excessive neurotransmitter release that is observed in certain neurological and psychotic disorders. Several randomized, double-blind, placebo-controlled studies have demonstrated that pregabalin has been effective in pain management, improving sleep quality and fatigue, as well as in several domains of health related quality of life. Because of mild to moderate adverse effects it can be considered a well-tolerated therapy for FM.Keywords: fibromyalgia, pregabalin, GABA analog, fibromyalgia treatment
format	article
author	Grazyna Zareba
author_facet	Grazyna Zareba
author_sort	Grazyna Zareba
title	New treatment options in the management of fibromyalgia: role of pregabalin
title_short	New treatment options in the management of fibromyalgia: role of pregabalin
title_full	New treatment options in the management of fibromyalgia: role of pregabalin
title_fullStr	New treatment options in the management of fibromyalgia: role of pregabalin
title_full_unstemmed	New treatment options in the management of fibromyalgia: role of pregabalin
title_sort	new treatment options in the management of fibromyalgia: role of pregabalin
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/5cb11c0d9c6942f8ad092d5545ad1fd6
work_keys_str_mv	AT grazynazareba newtreatmentoptionsinthemanagementoffibromyalgiaroleofpregabalin
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New treatment options in the management of fibromyalgia: role of pregabalin

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