SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells

The mechanism of resistance to EZH2 inhibitors in cancers with inactivating SWI/SNF mutations is unknown. Here, the authors demonstrate that the switch of the SWI/SNF catalytic subunits from SMARCA4 to SMARCA2 drives resistance to EZH2 inhibitors in ARID1A-mutated ovarian cancer cells.

Guardado en:

Detalles Bibliográficos
Autores principales:	Shuai Wu, Nail Fatkhutdinov, Takeshi Fukumoto, Benjamin G. Bitler, Pyoung Hwa Park, Andrew V. Kossenkov, Marco Trizzino, Hsin-Yao Tang, Lin Zhang, Alessandro Gardini, David W. Speicher, Rugang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5cb27163582a4d2c8042a94fcf015913
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5cb27163582a4d2c8042a94fcf015913
record_format	dspace
spelling	oai:doaj.org-article:5cb27163582a4d2c8042a94fcf0159132021-12-02T15:34:03ZSWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells10.1038/s41467-018-06656-62041-1723https://doaj.org/article/5cb27163582a4d2c8042a94fcf0159132018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06656-6https://doaj.org/toc/2041-1723The mechanism of resistance to EZH2 inhibitors in cancers with inactivating SWI/SNF mutations is unknown. Here, the authors demonstrate that the switch of the SWI/SNF catalytic subunits from SMARCA4 to SMARCA2 drives resistance to EZH2 inhibitors in ARID1A-mutated ovarian cancer cells.Shuai WuNail FatkhutdinovTakeshi FukumotoBenjamin G. BitlerPyoung Hwa ParkAndrew V. KossenkovMarco TrizzinoHsin-Yao TangLin ZhangAlessandro GardiniDavid W. SpeicherRugang ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shuai Wu Nail Fatkhutdinov Takeshi Fukumoto Benjamin G. Bitler Pyoung Hwa Park Andrew V. Kossenkov Marco Trizzino Hsin-Yao Tang Lin Zhang Alessandro Gardini David W. Speicher Rugang Zhang SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells
description	The mechanism of resistance to EZH2 inhibitors in cancers with inactivating SWI/SNF mutations is unknown. Here, the authors demonstrate that the switch of the SWI/SNF catalytic subunits from SMARCA4 to SMARCA2 drives resistance to EZH2 inhibitors in ARID1A-mutated ovarian cancer cells.
format	article
author	Shuai Wu Nail Fatkhutdinov Takeshi Fukumoto Benjamin G. Bitler Pyoung Hwa Park Andrew V. Kossenkov Marco Trizzino Hsin-Yao Tang Lin Zhang Alessandro Gardini David W. Speicher Rugang Zhang
author_facet	Shuai Wu Nail Fatkhutdinov Takeshi Fukumoto Benjamin G. Bitler Pyoung Hwa Park Andrew V. Kossenkov Marco Trizzino Hsin-Yao Tang Lin Zhang Alessandro Gardini David W. Speicher Rugang Zhang
author_sort	Shuai Wu
title	SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells
title_short	SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells
title_full	SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells
title_fullStr	SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells
title_full_unstemmed	SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells
title_sort	swi/snf catalytic subunits’ switch drives resistance to ezh2 inhibitors in arid1a-mutated cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5cb27163582a4d2c8042a94fcf015913
work_keys_str_mv	AT shuaiwu swisnfcatalyticsubunitsswitchdrivesresistancetoezh2inhibitorsinarid1amutatedcells AT nailfatkhutdinov swisnfcatalyticsubunitsswitchdrivesresistancetoezh2inhibitorsinarid1amutatedcells AT takeshifukumoto swisnfcatalyticsubunitsswitchdrivesresistancetoezh2inhibitorsinarid1amutatedcells AT benjamingbitler swisnfcatalyticsubunitsswitchdrivesresistancetoezh2inhibitorsinarid1amutatedcells AT pyounghwapark swisnfcatalyticsubunitsswitchdrivesresistancetoezh2inhibitorsinarid1amutatedcells AT andrewvkossenkov swisnfcatalyticsubunitsswitchdrivesresistancetoezh2inhibitorsinarid1amutatedcells AT marcotrizzino swisnfcatalyticsubunitsswitchdrivesresistancetoezh2inhibitorsinarid1amutatedcells AT hsinyaotang swisnfcatalyticsubunitsswitchdrivesresistancetoezh2inhibitorsinarid1amutatedcells AT linzhang swisnfcatalyticsubunitsswitchdrivesresistancetoezh2inhibitorsinarid1amutatedcells AT alessandrogardini swisnfcatalyticsubunitsswitchdrivesresistancetoezh2inhibitorsinarid1amutatedcells AT davidwspeicher swisnfcatalyticsubunitsswitchdrivesresistancetoezh2inhibitorsinarid1amutatedcells AT rugangzhang swisnfcatalyticsubunitsswitchdrivesresistancetoezh2inhibitorsinarid1amutatedcells
_version_	1718386962131320832

SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells

Ejemplares similares