Why are viral genomes so fragile? The bottleneck hypothesis.

If they undergo new mutations at each replication cycle, why are RNA viral genomes so fragile, with most mutations being either strongly deleterious or lethal? Here we provide theoretical and numerical evidence for the hypothesis that genetic fragility is partly an evolutionary response to the multi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nono S C Merleau, Sophie Pénisson, Philip J Gerrish, Santiago F Elena, Matteo Smerlak
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5cb2c75b535f4d34b1a1e02a06a24f53
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5cb2c75b535f4d34b1a1e02a06a24f53
record_format	dspace
spelling	oai:doaj.org-article:5cb2c75b535f4d34b1a1e02a06a24f532021-12-02T19:57:33ZWhy are viral genomes so fragile? The bottleneck hypothesis.1553-734X1553-735810.1371/journal.pcbi.1009128https://doaj.org/article/5cb2c75b535f4d34b1a1e02a06a24f532021-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009128https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358If they undergo new mutations at each replication cycle, why are RNA viral genomes so fragile, with most mutations being either strongly deleterious or lethal? Here we provide theoretical and numerical evidence for the hypothesis that genetic fragility is partly an evolutionary response to the multiple population bottlenecks experienced by viral populations at various stages of their life cycles. Modelling within-host viral populations as multi-type branching processes, we show that mutational fragility lowers the rate at which Muller's ratchet clicks and increases the survival probability through multiple bottlenecks. In the context of a susceptible-exposed-infectious-recovered epidemiological model, we find that the attack rate of fragile viral strains can exceed that of more robust strains, particularly at low infectivities and high mutation rates. Our findings highlight the importance of demographic events such as transmission bottlenecks in shaping the genetic architecture of viral pathogens.Nono S C MerleauSophie PénissonPhilip J GerrishSantiago F ElenaMatteo SmerlakPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 7, p e1009128 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Nono S C Merleau Sophie Pénisson Philip J Gerrish Santiago F Elena Matteo Smerlak Why are viral genomes so fragile? The bottleneck hypothesis.
description	If they undergo new mutations at each replication cycle, why are RNA viral genomes so fragile, with most mutations being either strongly deleterious or lethal? Here we provide theoretical and numerical evidence for the hypothesis that genetic fragility is partly an evolutionary response to the multiple population bottlenecks experienced by viral populations at various stages of their life cycles. Modelling within-host viral populations as multi-type branching processes, we show that mutational fragility lowers the rate at which Muller's ratchet clicks and increases the survival probability through multiple bottlenecks. In the context of a susceptible-exposed-infectious-recovered epidemiological model, we find that the attack rate of fragile viral strains can exceed that of more robust strains, particularly at low infectivities and high mutation rates. Our findings highlight the importance of demographic events such as transmission bottlenecks in shaping the genetic architecture of viral pathogens.
format	article
author	Nono S C Merleau Sophie Pénisson Philip J Gerrish Santiago F Elena Matteo Smerlak
author_facet	Nono S C Merleau Sophie Pénisson Philip J Gerrish Santiago F Elena Matteo Smerlak
author_sort	Nono S C Merleau
title	Why are viral genomes so fragile? The bottleneck hypothesis.
title_short	Why are viral genomes so fragile? The bottleneck hypothesis.
title_full	Why are viral genomes so fragile? The bottleneck hypothesis.
title_fullStr	Why are viral genomes so fragile? The bottleneck hypothesis.
title_full_unstemmed	Why are viral genomes so fragile? The bottleneck hypothesis.
title_sort	why are viral genomes so fragile? the bottleneck hypothesis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/5cb2c75b535f4d34b1a1e02a06a24f53
work_keys_str_mv	AT nonoscmerleau whyareviralgenomessofragilethebottleneckhypothesis AT sophiepenisson whyareviralgenomessofragilethebottleneckhypothesis AT philipjgerrish whyareviralgenomessofragilethebottleneckhypothesis AT santiagofelena whyareviralgenomessofragilethebottleneckhypothesis AT matteosmerlak whyareviralgenomessofragilethebottleneckhypothesis
_version_	1718375778816622592

Why are viral genomes so fragile? The bottleneck hypothesis.

Ejemplares similares