Why are viral genomes so fragile? The bottleneck hypothesis.
If they undergo new mutations at each replication cycle, why are RNA viral genomes so fragile, with most mutations being either strongly deleterious or lethal? Here we provide theoretical and numerical evidence for the hypothesis that genetic fragility is partly an evolutionary response to the multi...
Guardado en:
Autores principales: | Nono S C Merleau, Sophie Pénisson, Philip J Gerrish, Santiago F Elena, Matteo Smerlak |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/5cb2c75b535f4d34b1a1e02a06a24f53 |
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