Temporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling

Long-range looping of an enhancer to a promoter (E-P looping) is a key feature of gene activation; thus, regulation of E-P looping could serve as an effective strategy to precisely control gene expression. Here the authors propose the Drosophila chromatin insulator antagonist Shep represses expressi...

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Autores principales:	Dahong Chen, Catherine E. McManus, Behram Radmanesh, Leah H. Matzat, Elissa P. Lei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5cb314e949064507b4778645b69e034a
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spelling	oai:doaj.org-article:5cb314e949064507b4778645b69e034a2021-11-08T11:12:55ZTemporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling10.1038/s41467-021-26628-72041-1723https://doaj.org/article/5cb314e949064507b4778645b69e034a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26628-7https://doaj.org/toc/2041-1723Long-range looping of an enhancer to a promoter (E-P looping) is a key feature of gene activation; thus, regulation of E-P looping could serve as an effective strategy to precisely control gene expression. Here the authors propose the Drosophila chromatin insulator antagonist Shep represses expression of genes during neuronal maturation by preventing E-P looping.Dahong ChenCatherine E. McManusBehram RadmaneshLeah H. MatzatElissa P. LeiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dahong Chen Catherine E. McManus Behram Radmanesh Leah H. Matzat Elissa P. Lei Temporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling
description	Long-range looping of an enhancer to a promoter (E-P looping) is a key feature of gene activation; thus, regulation of E-P looping could serve as an effective strategy to precisely control gene expression. Here the authors propose the Drosophila chromatin insulator antagonist Shep represses expression of genes during neuronal maturation by preventing E-P looping.
format	article
author	Dahong Chen Catherine E. McManus Behram Radmanesh Leah H. Matzat Elissa P. Lei
author_facet	Dahong Chen Catherine E. McManus Behram Radmanesh Leah H. Matzat Elissa P. Lei
author_sort	Dahong Chen
title	Temporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling
title_short	Temporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling
title_full	Temporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling
title_fullStr	Temporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling
title_full_unstemmed	Temporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling
title_sort	temporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5cb314e949064507b4778645b69e034a
work_keys_str_mv	AT dahongchen temporalinhibitionofchromatinloopingandenhanceraccessibilityduringneuronalremodeling AT catherineemcmanus temporalinhibitionofchromatinloopingandenhanceraccessibilityduringneuronalremodeling AT behramradmanesh temporalinhibitionofchromatinloopingandenhanceraccessibilityduringneuronalremodeling AT leahhmatzat temporalinhibitionofchromatinloopingandenhanceraccessibilityduringneuronalremodeling AT elissaplei temporalinhibitionofchromatinloopingandenhanceraccessibilityduringneuronalremodeling
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Temporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling

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