Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes

RNA-dependent RNA polymerases from segmented negative stranded RNA viruses catalyze genome replication and viral transcription. Here, the authors present the cryo-EM structure of full-length La Crosse virus polymerase and structurally characterize the pre-initiation and elongation states, which is o...

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Autores principales:	Benoît Arragain, Grégory Effantin, Piotr Gerlach, Juan Reguera, Guy Schoehn, Stephen Cusack, Hélène Malet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5cb62ccd989949bab8fe52127c04e712
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spelling	oai:doaj.org-article:5cb62ccd989949bab8fe52127c04e7122021-12-02T15:33:16ZPre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes10.1038/s41467-020-17349-42041-1723https://doaj.org/article/5cb62ccd989949bab8fe52127c04e7122020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17349-4https://doaj.org/toc/2041-1723RNA-dependent RNA polymerases from segmented negative stranded RNA viruses catalyze genome replication and viral transcription. Here, the authors present the cryo-EM structure of full-length La Crosse virus polymerase and structurally characterize the pre-initiation and elongation states, which is of interest for the development of polymerase inhibitors.Benoît ArragainGrégory EffantinPiotr GerlachJuan RegueraGuy SchoehnStephen CusackHélène MaletNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benoît Arragain Grégory Effantin Piotr Gerlach Juan Reguera Guy Schoehn Stephen Cusack Hélène Malet Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes
description	RNA-dependent RNA polymerases from segmented negative stranded RNA viruses catalyze genome replication and viral transcription. Here, the authors present the cryo-EM structure of full-length La Crosse virus polymerase and structurally characterize the pre-initiation and elongation states, which is of interest for the development of polymerase inhibitors.
format	article
author	Benoît Arragain Grégory Effantin Piotr Gerlach Juan Reguera Guy Schoehn Stephen Cusack Hélène Malet
author_facet	Benoît Arragain Grégory Effantin Piotr Gerlach Juan Reguera Guy Schoehn Stephen Cusack Hélène Malet
author_sort	Benoît Arragain
title	Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes
title_short	Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes
title_full	Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes
title_fullStr	Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes
title_full_unstemmed	Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes
title_sort	pre-initiation and elongation structures of full-length la crosse virus polymerase reveal functionally important conformational changes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5cb62ccd989949bab8fe52127c04e712
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Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes

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