Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis

The LXR-SREBP1c pathway promotes hepatic lipogenesis that is deregualted in fatty liver disease. Here the authors show that the long noncoding RNA Blnc1 contributes to the development of obesity-driven steatosis by enabling SREBP1c trascriptional activity in response to LXR activation.

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Autores principales:	Xu-Yun Zhao, Xuelian Xiong, Tongyu Liu, Lin Mi, Xiaoling Peng, Crystal Rui, Liang Guo, Siming Li, Xiaoying Li, Jiandie D. Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5cb9c080fd1e4921b29a4d16a40ab672
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spelling	oai:doaj.org-article:5cb9c080fd1e4921b29a4d16a40ab6722021-12-02T17:31:28ZLong noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis10.1038/s41467-018-05383-22041-1723https://doaj.org/article/5cb9c080fd1e4921b29a4d16a40ab6722018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05383-2https://doaj.org/toc/2041-1723The LXR-SREBP1c pathway promotes hepatic lipogenesis that is deregualted in fatty liver disease. Here the authors show that the long noncoding RNA Blnc1 contributes to the development of obesity-driven steatosis by enabling SREBP1c trascriptional activity in response to LXR activation.Xu-Yun ZhaoXuelian XiongTongyu LiuLin MiXiaoling PengCrystal RuiLiang GuoSiming LiXiaoying LiJiandie D. LinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xu-Yun Zhao Xuelian Xiong Tongyu Liu Lin Mi Xiaoling Peng Crystal Rui Liang Guo Siming Li Xiaoying Li Jiandie D. Lin Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis
description	The LXR-SREBP1c pathway promotes hepatic lipogenesis that is deregualted in fatty liver disease. Here the authors show that the long noncoding RNA Blnc1 contributes to the development of obesity-driven steatosis by enabling SREBP1c trascriptional activity in response to LXR activation.
format	article
author	Xu-Yun Zhao Xuelian Xiong Tongyu Liu Lin Mi Xiaoling Peng Crystal Rui Liang Guo Siming Li Xiaoying Li Jiandie D. Lin
author_facet	Xu-Yun Zhao Xuelian Xiong Tongyu Liu Lin Mi Xiaoling Peng Crystal Rui Liang Guo Siming Li Xiaoying Li Jiandie D. Lin
author_sort	Xu-Yun Zhao
title	Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis
title_short	Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis
title_full	Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis
title_fullStr	Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis
title_full_unstemmed	Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis
title_sort	long noncoding rna licensing of obesity-linked hepatic lipogenesis and nafld pathogenesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5cb9c080fd1e4921b29a4d16a40ab672
work_keys_str_mv	AT xuyunzhao longnoncodingrnalicensingofobesitylinkedhepaticlipogenesisandnafldpathogenesis AT xuelianxiong longnoncodingrnalicensingofobesitylinkedhepaticlipogenesisandnafldpathogenesis AT tongyuliu longnoncodingrnalicensingofobesitylinkedhepaticlipogenesisandnafldpathogenesis AT linmi longnoncodingrnalicensingofobesitylinkedhepaticlipogenesisandnafldpathogenesis AT xiaolingpeng longnoncodingrnalicensingofobesitylinkedhepaticlipogenesisandnafldpathogenesis AT crystalrui longnoncodingrnalicensingofobesitylinkedhepaticlipogenesisandnafldpathogenesis AT liangguo longnoncodingrnalicensingofobesitylinkedhepaticlipogenesisandnafldpathogenesis AT simingli longnoncodingrnalicensingofobesitylinkedhepaticlipogenesisandnafldpathogenesis AT xiaoyingli longnoncodingrnalicensingofobesitylinkedhepaticlipogenesisandnafldpathogenesis AT jiandiedlin longnoncodingrnalicensingofobesitylinkedhepaticlipogenesisandnafldpathogenesis
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Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis

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