Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis

Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis

The LXR-SREBP1c pathway promotes hepatic lipogenesis that is deregualted in fatty liver disease. Here the authors show that the long noncoding RNA Blnc1 contributes to the development of obesity-driven steatosis by enabling SREBP1c trascriptional activity in response to LXR activation.

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Autores principales: Xu-Yun Zhao, Xuelian Xiong, Tongyu Liu, Lin Mi, Xiaoling Peng, Crystal Rui, Liang Guo, Siming Li, Xiaoying Li, Jiandie D. Lin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/5cb9c080fd1e4921b29a4d16a40ab672
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