An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model
DNA-delivered monoclonal antibodies (DMAbs) can be produced by muscle cells in vivo, potentially allowing prevention or treatment of infectious diseases. Here, the authors show that two DMAbs targeting Pseudomonas aeruginosa proteins confer protection against lethal pneumonia in mice.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/5cc6f71f1078455d97d037b4f8457a6b |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:5cc6f71f1078455d97d037b4f8457a6b |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:5cc6f71f1078455d97d037b4f8457a6b2021-12-02T15:38:42ZAn engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model10.1038/s41467-017-00576-72041-1723https://doaj.org/article/5cc6f71f1078455d97d037b4f8457a6b2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00576-7https://doaj.org/toc/2041-1723DNA-delivered monoclonal antibodies (DMAbs) can be produced by muscle cells in vivo, potentially allowing prevention or treatment of infectious diseases. Here, the authors show that two DMAbs targeting Pseudomonas aeruginosa proteins confer protection against lethal pneumonia in mice.Ami PatelAntonio DiGiandomenicoAshley E. KellerTrevor R. F. SmithDaniel H. ParkStephanie RamosKatherine SchultheisSarah T. C. ElliottJaness MendozaKate E. BroderickMegan C. WiseJian YanJingjing JiangSeleeke FlingaiAmir S. KhanKar MuthumaniLaurent HumeauLily I. ChengLeslie Wachter-RosatiC. Kendall StoverNiranjan Y. SardesaiDavid B. WeinerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ami Patel Antonio DiGiandomenico Ashley E. Keller Trevor R. F. Smith Daniel H. Park Stephanie Ramos Katherine Schultheis Sarah T. C. Elliott Janess Mendoza Kate E. Broderick Megan C. Wise Jian Yan Jingjing Jiang Seleeke Flingai Amir S. Khan Kar Muthumani Laurent Humeau Lily I. Cheng Leslie Wachter-Rosati C. Kendall Stover Niranjan Y. Sardesai David B. Weiner An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model |
| description |
DNA-delivered monoclonal antibodies (DMAbs) can be produced by muscle cells in vivo, potentially allowing prevention or treatment of infectious diseases. Here, the authors show that two DMAbs targeting Pseudomonas aeruginosa proteins confer protection against lethal pneumonia in mice. |
| format |
article |
| author |
Ami Patel Antonio DiGiandomenico Ashley E. Keller Trevor R. F. Smith Daniel H. Park Stephanie Ramos Katherine Schultheis Sarah T. C. Elliott Janess Mendoza Kate E. Broderick Megan C. Wise Jian Yan Jingjing Jiang Seleeke Flingai Amir S. Khan Kar Muthumani Laurent Humeau Lily I. Cheng Leslie Wachter-Rosati C. Kendall Stover Niranjan Y. Sardesai David B. Weiner |
| author_facet |
Ami Patel Antonio DiGiandomenico Ashley E. Keller Trevor R. F. Smith Daniel H. Park Stephanie Ramos Katherine Schultheis Sarah T. C. Elliott Janess Mendoza Kate E. Broderick Megan C. Wise Jian Yan Jingjing Jiang Seleeke Flingai Amir S. Khan Kar Muthumani Laurent Humeau Lily I. Cheng Leslie Wachter-Rosati C. Kendall Stover Niranjan Y. Sardesai David B. Weiner |
| author_sort |
Ami Patel |
| title |
An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model |
| title_short |
An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model |
| title_full |
An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model |
| title_fullStr |
An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model |
| title_full_unstemmed |
An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model |
| title_sort |
engineered bispecific dna-encoded igg antibody protects against pseudomonas aeruginosa in a pneumonia challenge model |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/5cc6f71f1078455d97d037b4f8457a6b |
| work_keys_str_mv |
AT amipatel anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT antoniodigiandomenico anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT ashleyekeller anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT trevorrfsmith anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT danielhpark anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT stephanieramos anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT katherineschultheis anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT sarahtcelliott anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT janessmendoza anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT kateebroderick anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT megancwise anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT jianyan anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT jingjingjiang anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT seleekeflingai anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT amirskhan anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT karmuthumani anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT laurenthumeau anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT lilyicheng anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT lesliewachterrosati anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT ckendallstover anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT niranjanysardesai anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT davidbweiner anengineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT amipatel engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT antoniodigiandomenico engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT ashleyekeller engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT trevorrfsmith engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT danielhpark engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT stephanieramos engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT katherineschultheis engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT sarahtcelliott engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT janessmendoza engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT kateebroderick engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT megancwise engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT jianyan engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT jingjingjiang engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT seleekeflingai engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT amirskhan engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT karmuthumani engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT laurenthumeau engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT lilyicheng engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT lesliewachterrosati engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT ckendallstover engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT niranjanysardesai engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel AT davidbweiner engineeredbispecificdnaencodediggantibodyprotectsagainstpseudomonasaeruginosainapneumoniachallengemodel |
| _version_ |
1718386112258375680 |