Associations between race, APOE genotype, cognition, and mortality among urban middle-aged white and African American adults

Abstract We examined associations between cognition and mortality and how these relationships vary by race and Apolipoprotein E (APOE) genotype, in a longitudinal study of 2346 middle-aged White and African American adults (30–64 years at baseline) from the Healthy Aging in Neighborhoods of Diversit...

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Autores principales:	Jordan Weiss, Sharmin Hossain, Ana I. Maldonado, Botong Shen, Hind A. Beydoun, Mika Kivimaki, Michele K. Evans, Alan B. Zonderman, May A. Beydoun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5cc77c989946447db7a8cc80354dd853
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spelling	oai:doaj.org-article:5cc77c989946447db7a8cc80354dd8532021-12-02T18:01:48ZAssociations between race, APOE genotype, cognition, and mortality among urban middle-aged white and African American adults10.1038/s41598-021-98117-22045-2322https://doaj.org/article/5cc77c989946447db7a8cc80354dd8532021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98117-2https://doaj.org/toc/2045-2322Abstract We examined associations between cognition and mortality and how these relationships vary by race and Apolipoprotein E (APOE) genotype, in a longitudinal study of 2346 middle-aged White and African American adults (30–64 years at baseline) from the Healthy Aging in Neighborhoods of Diversity across the Life Span cohort study. Baseline cognition spanned global mental status, and several domains obtained using principal components analysis (PCA; PCA1: verbal memory/fluency; PCA2: attention/working memory; PCA3: executive function/visuo-spatial abilities). Cox regression models evaluated associations between cognition and all-cause and cardiovascular disease (CVD)-mortality. Interactions between cognition and APOE2 as well as APOE4 allelic dose were tested, and race was a key effect modifier. Higher APOE4 dose was associated with increased CVD-mortality (hazard ratio [HR] per allele = 1.37; 95% CI 1.01–1.86, p = 0.041); APOE2 dosage’s association with CVD-mortality was non-significant (HR = 0.60; 95% CI 0.35–1.03, p = 0.065). Higher PCA3 was associated with lower all-cause (HR = 0.93; 95% CI 0.87–0.99, p = 0.030) and CVD (HR = 0.85; 95% CI 0.77–0.95, p = 0.001) mortality risks, the latter association being more pronounced among Whites. PCA2 interacted synergistically with APOE2 dosage, reducing risks for all-cause mortality (PCA2 × APOE2: − 0.33 ± 0.13, p = 0.010) and CVD mortality (PCA2 × APOE2: − 0.73 ± 0.31, p = 0.019). In conclusion, greater executive function/visuo-spatial abilities were associated with reduced CVD-specific mortality, particularly among Whites. Greater “attention/working memory” coupled with higher APOE2 dosage was linked with reduced all-cause and CVD mortality risks.Jordan WeissSharmin HossainAna I. MaldonadoBotong ShenHind A. BeydounMika KivimakiMichele K. EvansAlan B. ZondermanMay A. BeydounNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jordan Weiss Sharmin Hossain Ana I. Maldonado Botong Shen Hind A. Beydoun Mika Kivimaki Michele K. Evans Alan B. Zonderman May A. Beydoun Associations between race, APOE genotype, cognition, and mortality among urban middle-aged white and African American adults
description	Abstract We examined associations between cognition and mortality and how these relationships vary by race and Apolipoprotein E (APOE) genotype, in a longitudinal study of 2346 middle-aged White and African American adults (30–64 years at baseline) from the Healthy Aging in Neighborhoods of Diversity across the Life Span cohort study. Baseline cognition spanned global mental status, and several domains obtained using principal components analysis (PCA; PCA1: verbal memory/fluency; PCA2: attention/working memory; PCA3: executive function/visuo-spatial abilities). Cox regression models evaluated associations between cognition and all-cause and cardiovascular disease (CVD)-mortality. Interactions between cognition and APOE2 as well as APOE4 allelic dose were tested, and race was a key effect modifier. Higher APOE4 dose was associated with increased CVD-mortality (hazard ratio [HR] per allele = 1.37; 95% CI 1.01–1.86, p = 0.041); APOE2 dosage’s association with CVD-mortality was non-significant (HR = 0.60; 95% CI 0.35–1.03, p = 0.065). Higher PCA3 was associated with lower all-cause (HR = 0.93; 95% CI 0.87–0.99, p = 0.030) and CVD (HR = 0.85; 95% CI 0.77–0.95, p = 0.001) mortality risks, the latter association being more pronounced among Whites. PCA2 interacted synergistically with APOE2 dosage, reducing risks for all-cause mortality (PCA2 × APOE2: − 0.33 ± 0.13, p = 0.010) and CVD mortality (PCA2 × APOE2: − 0.73 ± 0.31, p = 0.019). In conclusion, greater executive function/visuo-spatial abilities were associated with reduced CVD-specific mortality, particularly among Whites. Greater “attention/working memory” coupled with higher APOE2 dosage was linked with reduced all-cause and CVD mortality risks.
format	article
author	Jordan Weiss Sharmin Hossain Ana I. Maldonado Botong Shen Hind A. Beydoun Mika Kivimaki Michele K. Evans Alan B. Zonderman May A. Beydoun
author_facet	Jordan Weiss Sharmin Hossain Ana I. Maldonado Botong Shen Hind A. Beydoun Mika Kivimaki Michele K. Evans Alan B. Zonderman May A. Beydoun
author_sort	Jordan Weiss
title	Associations between race, APOE genotype, cognition, and mortality among urban middle-aged white and African American adults
title_short	Associations between race, APOE genotype, cognition, and mortality among urban middle-aged white and African American adults
title_full	Associations between race, APOE genotype, cognition, and mortality among urban middle-aged white and African American adults
title_fullStr	Associations between race, APOE genotype, cognition, and mortality among urban middle-aged white and African American adults
title_full_unstemmed	Associations between race, APOE genotype, cognition, and mortality among urban middle-aged white and African American adults
title_sort	associations between race, apoe genotype, cognition, and mortality among urban middle-aged white and african american adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5cc77c989946447db7a8cc80354dd853
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Associations between race, APOE genotype, cognition, and mortality among urban middle-aged white and African American adults

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