HLA DRB1 and HLA DQB1 Alleles in Bulgarian Patients with Primary and Secondary Antiphospholipid Syndrome

Antiphospholipid syndrome (APS) is an autoimmune disease with multifactorial and polygenic pathogenesis. Recently, the genetic predisposition in APS has been subjected to wide discussion. The aim of this study is to determine the prevalence of DRB1 and DQB1 loci in Bulgarian population of healthy pe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Baleva M., Nikolova-Vlahova M., Lukanov Tsv., Ivanova-Shivarova M., Karagjozova Zh., Martinova F., Naumova E.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2019
Materias:	antiphospholipid syndrome spontaneous abortions systemic lupus erythematosus hla drb1 hla dqb1 Medicine R
Acceso en línea:	https://doaj.org/article/5cc886593f3b42ee88d8e601835a557a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5cc886593f3b42ee88d8e601835a557a
record_format	dspace
spelling	oai:doaj.org-article:5cc886593f3b42ee88d8e601835a557a2021-12-02T19:11:32ZHLA DRB1 and HLA DQB1 Alleles in Bulgarian Patients with Primary and Secondary Antiphospholipid Syndrome0324-175010.2478/amb-2019-0002https://doaj.org/article/5cc886593f3b42ee88d8e601835a557a2019-02-01T00:00:00Zhttps://doi.org/10.2478/amb-2019-0002https://doaj.org/toc/0324-1750Antiphospholipid syndrome (APS) is an autoimmune disease with multifactorial and polygenic pathogenesis. Recently, the genetic predisposition in APS has been subjected to wide discussion. The aim of this study is to determine the prevalence of DRB1 and DQB1 loci in Bulgarian population of healthy persons and patients with primary (PAPS) and secondary (SAPS) APS. Patients are divided in 5 groups: I-29 patents with systemic lupus erythematosus (SLE) with SAPS, II-35 patients with PAPS, III-32 women with spontaneous abortions without aPL, IV-15 patients with different thrombosis (deep venous thromboses, pulmonary embolism, mesenterial thrombosis, myocardial infarction, stroke) without laboratory data for APS, and V-16 SLE patients without clinical and laboratory data for APS. SAPS patients have more frequently DRB103 and DQB102 and more rarely DRB111 and DQB103 in comparison with healthy subjects and patients with PAPS. Patents with PAPS, those with spontaneous abortions and patients with thrombotic events but without antiphospholipid antibodies (aPL) have DRB103, DRB111, DQB102 and DQB103 alleles similar to the general population. There are no differences between group I (SLE+APS) and group V (SLE) in DRB1* and DQB1*alleles.Baleva M.Nikolova-Vlahova M.Lukanov Tsv.Ivanova-Shivarova M.Karagjozova Zh.Martinova F.Naumova E.Sciendoarticleantiphospholipid syndromespontaneous abortionssystemic lupus erythematosushla drb1hla dqb1MedicineRENActa Medica Bulgarica, Vol 46, Iss 1, Pp 11-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	antiphospholipid syndrome spontaneous abortions systemic lupus erythematosus hla drb1 hla dqb1 Medicine R
spellingShingle	antiphospholipid syndrome spontaneous abortions systemic lupus erythematosus hla drb1 hla dqb1 Medicine R Baleva M. Nikolova-Vlahova M. Lukanov Tsv. Ivanova-Shivarova M. Karagjozova Zh. Martinova F. Naumova E. HLA DRB1 and HLA DQB1 Alleles in Bulgarian Patients with Primary and Secondary Antiphospholipid Syndrome
description	Antiphospholipid syndrome (APS) is an autoimmune disease with multifactorial and polygenic pathogenesis. Recently, the genetic predisposition in APS has been subjected to wide discussion. The aim of this study is to determine the prevalence of DRB1 and DQB1 loci in Bulgarian population of healthy persons and patients with primary (PAPS) and secondary (SAPS) APS. Patients are divided in 5 groups: I-29 patents with systemic lupus erythematosus (SLE) with SAPS, II-35 patients with PAPS, III-32 women with spontaneous abortions without aPL, IV-15 patients with different thrombosis (deep venous thromboses, pulmonary embolism, mesenterial thrombosis, myocardial infarction, stroke) without laboratory data for APS, and V-16 SLE patients without clinical and laboratory data for APS. SAPS patients have more frequently DRB103 and DQB102 and more rarely DRB111 and DQB103 in comparison with healthy subjects and patients with PAPS. Patents with PAPS, those with spontaneous abortions and patients with thrombotic events but without antiphospholipid antibodies (aPL) have DRB103, DRB111, DQB102 and DQB103 alleles similar to the general population. There are no differences between group I (SLE+APS) and group V (SLE) in DRB1* and DQB1*alleles.
format	article
author	Baleva M. Nikolova-Vlahova M. Lukanov Tsv. Ivanova-Shivarova M. Karagjozova Zh. Martinova F. Naumova E.
author_facet	Baleva M. Nikolova-Vlahova M. Lukanov Tsv. Ivanova-Shivarova M. Karagjozova Zh. Martinova F. Naumova E.
author_sort	Baleva M.
title	HLA DRB1 and HLA DQB1 Alleles in Bulgarian Patients with Primary and Secondary Antiphospholipid Syndrome
title_short	HLA DRB1 and HLA DQB1 Alleles in Bulgarian Patients with Primary and Secondary Antiphospholipid Syndrome
title_full	HLA DRB1 and HLA DQB1 Alleles in Bulgarian Patients with Primary and Secondary Antiphospholipid Syndrome
title_fullStr	HLA DRB1 and HLA DQB1 Alleles in Bulgarian Patients with Primary and Secondary Antiphospholipid Syndrome
title_full_unstemmed	HLA DRB1 and HLA DQB1 Alleles in Bulgarian Patients with Primary and Secondary Antiphospholipid Syndrome
title_sort	hla drb1 and hla dqb1 alleles in bulgarian patients with primary and secondary antiphospholipid syndrome
publisher	Sciendo
publishDate	2019
url	https://doaj.org/article/5cc886593f3b42ee88d8e601835a557a
work_keys_str_mv	AT balevam hladrb1andhladqb1allelesinbulgarianpatientswithprimaryandsecondaryantiphospholipidsyndrome AT nikolovavlahovam hladrb1andhladqb1allelesinbulgarianpatientswithprimaryandsecondaryantiphospholipidsyndrome AT lukanovtsv hladrb1andhladqb1allelesinbulgarianpatientswithprimaryandsecondaryantiphospholipidsyndrome AT ivanovashivarovam hladrb1andhladqb1allelesinbulgarianpatientswithprimaryandsecondaryantiphospholipidsyndrome AT karagjozovazh hladrb1andhladqb1allelesinbulgarianpatientswithprimaryandsecondaryantiphospholipidsyndrome AT martinovaf hladrb1andhladqb1allelesinbulgarianpatientswithprimaryandsecondaryantiphospholipidsyndrome AT naumovae hladrb1andhladqb1allelesinbulgarianpatientswithprimaryandsecondaryantiphospholipidsyndrome
_version_	1718377088341245952

HLA DRB1 and HLA DQB1 Alleles in Bulgarian Patients with Primary and Secondary Antiphospholipid Syndrome

Ejemplares similares