ROLE OF HEPATITIS C VIRUS COINFECTION IN VIOLATION OF PRODUCTIVE THYMIC FUNCTION IN HIV-INFECTED PATIENTS UNDER IMMUNOLOGICALLY INEFFICIENT ANTIRETROVIRAL THERAPY

Abstract. The role of hepatitis C virus (HCV) co-infection in violation of restoring CD4+T cells in HIVinfected patients receiving antiretroviral therapy (ART) was investigated. Seventy eight patients with effective virological response to ART (viral load < 50 copies/ml) who either had or had...

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Autores principales:	E. V. Saidakova, L. B. Korolevskaya, N. G. Shmagel, K. V. Shmagel, V. A. Chereshnev
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	hiv/hcv-coinfection antiretroviral therapy immunological areactivity apoptosis thymic productive function Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5cc9bee1c44047c78726ba830fdb44f9
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spelling	oai:doaj.org-article:5cc9bee1c44047c78726ba830fdb44f92021-11-18T08:03:43ZROLE OF HEPATITIS C VIRUS COINFECTION IN VIOLATION OF PRODUCTIVE THYMIC FUNCTION IN HIV-INFECTED PATIENTS UNDER IMMUNOLOGICALLY INEFFICIENT ANTIRETROVIRAL THERAPY1563-06252313-741X10.15789/1563-0625-2013-6-543-552https://doaj.org/article/5cc9bee1c44047c78726ba830fdb44f92014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/673https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The role of hepatitis C virus (HCV) co-infection in violation of restoring CD4+T cells in HIVinfected patients receiving antiretroviral therapy (ART) was investigated. Seventy eight patients with effective virological response to ART (viral load < 50 copies/ml) who either had or had no good immunological CD4+Tcell response after two years of treatment were recruited. Twenty one relatively healthy volunteers served as controls. The numbers of main T-lymphocyte populations and their apoptosis rates were determined. Thymus productive function was assessed by the number of αTREC-positive CD4+ and CD8+T cells. It is shown that HIV/HCV co-infection is characterized by lower numbers of CD4+T-lymphocytes in patients’ blood compared with HIV-monoinfection. This is not associated with the cells’ increased death rates. We also demonstrate that HCV coinfection reduces the production of CD4+, but not CD8+T-lymphocytes, by the thymus.E. V. SaidakovaL. B. KorolevskayaN. G. ShmagelK. V. ShmagelV. A. ChereshnevSPb RAACIarticlehiv/hcv-coinfectionantiretroviral therapyimmunological areactivityapoptosisthymic productive functionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 6, Pp 543-552 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	hiv/hcv-coinfection antiretroviral therapy immunological areactivity apoptosis thymic productive function Immunologic diseases. Allergy RC581-607
spellingShingle	hiv/hcv-coinfection antiretroviral therapy immunological areactivity apoptosis thymic productive function Immunologic diseases. Allergy RC581-607 E. V. Saidakova L. B. Korolevskaya N. G. Shmagel K. V. Shmagel V. A. Chereshnev ROLE OF HEPATITIS C VIRUS COINFECTION IN VIOLATION OF PRODUCTIVE THYMIC FUNCTION IN HIV-INFECTED PATIENTS UNDER IMMUNOLOGICALLY INEFFICIENT ANTIRETROVIRAL THERAPY
description	Abstract. The role of hepatitis C virus (HCV) co-infection in violation of restoring CD4+T cells in HIVinfected patients receiving antiretroviral therapy (ART) was investigated. Seventy eight patients with effective virological response to ART (viral load < 50 copies/ml) who either had or had no good immunological CD4+Tcell response after two years of treatment were recruited. Twenty one relatively healthy volunteers served as controls. The numbers of main T-lymphocyte populations and their apoptosis rates were determined. Thymus productive function was assessed by the number of αTREC-positive CD4+ and CD8+T cells. It is shown that HIV/HCV co-infection is characterized by lower numbers of CD4+T-lymphocytes in patients’ blood compared with HIV-monoinfection. This is not associated with the cells’ increased death rates. We also demonstrate that HCV coinfection reduces the production of CD4+, but not CD8+T-lymphocytes, by the thymus.
format	article
author	E. V. Saidakova L. B. Korolevskaya N. G. Shmagel K. V. Shmagel V. A. Chereshnev
author_facet	E. V. Saidakova L. B. Korolevskaya N. G. Shmagel K. V. Shmagel V. A. Chereshnev
author_sort	E. V. Saidakova
title	ROLE OF HEPATITIS C VIRUS COINFECTION IN VIOLATION OF PRODUCTIVE THYMIC FUNCTION IN HIV-INFECTED PATIENTS UNDER IMMUNOLOGICALLY INEFFICIENT ANTIRETROVIRAL THERAPY
title_short	ROLE OF HEPATITIS C VIRUS COINFECTION IN VIOLATION OF PRODUCTIVE THYMIC FUNCTION IN HIV-INFECTED PATIENTS UNDER IMMUNOLOGICALLY INEFFICIENT ANTIRETROVIRAL THERAPY
title_full	ROLE OF HEPATITIS C VIRUS COINFECTION IN VIOLATION OF PRODUCTIVE THYMIC FUNCTION IN HIV-INFECTED PATIENTS UNDER IMMUNOLOGICALLY INEFFICIENT ANTIRETROVIRAL THERAPY
title_fullStr	ROLE OF HEPATITIS C VIRUS COINFECTION IN VIOLATION OF PRODUCTIVE THYMIC FUNCTION IN HIV-INFECTED PATIENTS UNDER IMMUNOLOGICALLY INEFFICIENT ANTIRETROVIRAL THERAPY
title_full_unstemmed	ROLE OF HEPATITIS C VIRUS COINFECTION IN VIOLATION OF PRODUCTIVE THYMIC FUNCTION IN HIV-INFECTED PATIENTS UNDER IMMUNOLOGICALLY INEFFICIENT ANTIRETROVIRAL THERAPY
title_sort	role of hepatitis c virus coinfection in violation of productive thymic function in hiv-infected patients under immunologically inefficient antiretroviral therapy
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/5cc9bee1c44047c78726ba830fdb44f9
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ROLE OF HEPATITIS C VIRUS COINFECTION IN VIOLATION OF PRODUCTIVE THYMIC FUNCTION IN HIV-INFECTED PATIENTS UNDER IMMUNOLOGICALLY INEFFICIENT ANTIRETROVIRAL THERAPY

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