Imaging choroidal neovascular membrane using en face swept-source optical coherence tomography angiography

Magdy Moussa,1,2 Mahmoud Leila,3 Hagar Khalid1,2 1Ophthalmology Department, Faculty of Medicine, Tanta University, Tanta, Egypt; 2MEDIC Eye Center, Tanta, Egypt; 3Retina Department, Research Institute of Ophthalmology, Giza, Egypt Purpose: The aim of this study was to assess the efficacy of swept-...

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Autores principales:	Moussa M, Leila M, Khalid H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Swept-source OCT OCT angiography Imaging of CNV OCTARA algorithm Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/5cca61eceac446c9bb2093e8f79eca0d
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spelling	oai:doaj.org-article:5cca61eceac446c9bb2093e8f79eca0d2021-12-02T00:10:31ZImaging choroidal neovascular membrane using en face swept-source optical coherence tomography angiography1177-5483https://doaj.org/article/5cca61eceac446c9bb2093e8f79eca0d2017-10-01T00:00:00Zhttps://www.dovepress.com/imaging-choroidal-neovascular-membrane-using-en-face-swept-source-opti-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Magdy Moussa,1,2 Mahmoud Leila,3 Hagar Khalid1,2 1Ophthalmology Department, Faculty of Medicine, Tanta University, Tanta, Egypt; 2MEDIC Eye Center, Tanta, Egypt; 3Retina Department, Research Institute of Ophthalmology, Giza, Egypt Purpose: The aim of this study was to assess the efficacy of swept-source optical coherence tomography angiography (SS-OCTA) in delineating the morphology of choroidal neovascular membrane (CNV). Patients and methods: This was a retrospective observational case series reviewing clinical data and fundus fluorescein angiography (FFA), swept-source optical coherence tomography (SS-OCT), and SS-OCTA images of patients with CNV and comparing the findings. The swept-source technology enables deeper penetration and superior axial resolution. The incorporated blood flow detection algorithm, optical coherence tomography angiography ratio analysis (OCTARA), enables visualization of CNV in vivo without the need for dye injection. Results: The study included 136 eyes of 105 patients. Active lesions on SS-OCTA images showed increased capillary density, extensive arborization, vascular anastomosis and looping, and peri-lesional hollow. Inactive lesions showed decreased capillary density, presence of large linear vessels, and presence of feeder vessels supplying the CNV. We detected positive correlation between SS-OCTA, FFA, and SS-OCT images in 97% of eyes. In the remaining 3%, SS-OCTA confirmed the absence of CNV, whereas FFA and SS-OCT either were inconclusive in the diagnosis of CNV or yielded false-positive results. Conclusion: SS-OCT and SS-OCTA represent a reproducible risk-free analog for FFA in imaging CNV. SS-OCTA is particularly versatile in cases where FFA and SS-OCT are inconclusive. Keywords: swept-source OCT, OCT angiography, imaging of CNV, OCTARA algorithmMoussa MLeila MKhalid HDove Medical PressarticleSwept-source OCTOCT angiographyImaging of CNVOCTARA algorithmOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 1859-1869 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Swept-source OCT OCT angiography Imaging of CNV OCTARA algorithm Ophthalmology RE1-994
spellingShingle	Swept-source OCT OCT angiography Imaging of CNV OCTARA algorithm Ophthalmology RE1-994 Moussa M Leila M Khalid H Imaging choroidal neovascular membrane using en face swept-source optical coherence tomography angiography
description	Magdy Moussa,1,2 Mahmoud Leila,3 Hagar Khalid1,2 1Ophthalmology Department, Faculty of Medicine, Tanta University, Tanta, Egypt; 2MEDIC Eye Center, Tanta, Egypt; 3Retina Department, Research Institute of Ophthalmology, Giza, Egypt Purpose: The aim of this study was to assess the efficacy of swept-source optical coherence tomography angiography (SS-OCTA) in delineating the morphology of choroidal neovascular membrane (CNV). Patients and methods: This was a retrospective observational case series reviewing clinical data and fundus fluorescein angiography (FFA), swept-source optical coherence tomography (SS-OCT), and SS-OCTA images of patients with CNV and comparing the findings. The swept-source technology enables deeper penetration and superior axial resolution. The incorporated blood flow detection algorithm, optical coherence tomography angiography ratio analysis (OCTARA), enables visualization of CNV in vivo without the need for dye injection. Results: The study included 136 eyes of 105 patients. Active lesions on SS-OCTA images showed increased capillary density, extensive arborization, vascular anastomosis and looping, and peri-lesional hollow. Inactive lesions showed decreased capillary density, presence of large linear vessels, and presence of feeder vessels supplying the CNV. We detected positive correlation between SS-OCTA, FFA, and SS-OCT images in 97% of eyes. In the remaining 3%, SS-OCTA confirmed the absence of CNV, whereas FFA and SS-OCT either were inconclusive in the diagnosis of CNV or yielded false-positive results. Conclusion: SS-OCT and SS-OCTA represent a reproducible risk-free analog for FFA in imaging CNV. SS-OCTA is particularly versatile in cases where FFA and SS-OCT are inconclusive. Keywords: swept-source OCT, OCT angiography, imaging of CNV, OCTARA algorithm
format	article
author	Moussa M Leila M Khalid H
author_facet	Moussa M Leila M Khalid H
author_sort	Moussa M
title	Imaging choroidal neovascular membrane using en face swept-source optical coherence tomography angiography
title_short	Imaging choroidal neovascular membrane using en face swept-source optical coherence tomography angiography
title_full	Imaging choroidal neovascular membrane using en face swept-source optical coherence tomography angiography
title_fullStr	Imaging choroidal neovascular membrane using en face swept-source optical coherence tomography angiography
title_full_unstemmed	Imaging choroidal neovascular membrane using en face swept-source optical coherence tomography angiography
title_sort	imaging choroidal neovascular membrane using en face swept-source optical coherence tomography angiography
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/5cca61eceac446c9bb2093e8f79eca0d
work_keys_str_mv	AT moussam imagingchoroidalneovascularmembraneusingenfacesweptsourceopticalcoherencetomographyangiography AT leilam imagingchoroidalneovascularmembraneusingenfacesweptsourceopticalcoherencetomographyangiography AT khalidh imagingchoroidalneovascularmembraneusingenfacesweptsourceopticalcoherencetomographyangiography
_version_	1718403868744744960

Imaging choroidal neovascular membrane using en face swept-source optical coherence tomography angiography

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