Stem cell transplantation dose in patients with acute myocardial infarction: A meta-analysis

Objective: To evaluate whether stem cell transplantation improves global left ventricular ejection fraction (LVEF) in patients with acute myocardial infarction (AMI), and to determine the appropriate stem cell therapy dose as well as the effective period after stem cell transplantation for therapy....

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Autores principales:	Jia-Ying Xu, Wen-Yuan Cai, Ming Tian, Dai Liu, Rong-Chong Huang
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2016
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5ccacde413b44f01b7926c2aac07a93d
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spelling	oai:doaj.org-article:5ccacde413b44f01b7926c2aac07a93d2021-12-02T10:50:43ZStem cell transplantation dose in patients with acute myocardial infarction: A meta-analysis2095-882X10.1016/j.cdtm.2016.09.006https://doaj.org/article/5ccacde413b44f01b7926c2aac07a93d2016-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X16300743https://doaj.org/toc/2095-882XObjective: To evaluate whether stem cell transplantation improves global left ventricular ejection fraction (LVEF) in patients with acute myocardial infarction (AMI), and to determine the appropriate stem cell therapy dose as well as the effective period after stem cell transplantation for therapy. Methods: A systematic literature search included Pubmed, MEDLINE, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), and Cochrane Evidence-Based Medicine databases. The retrieval time limit ranged from January 1990 to June 2016. We also obtained full texts through manual retrieval, interlibrary loan and document delivery service, or by contacting the authors directly. According to our inclusion and exclusion criteria, data were extracted independently by two evaluators. In case of disagreement, a joint discussion occurred and a third researcher was utilized. Data were analyzed quantitatively using Revman 5.2. Summary results are presented as the weighted mean difference (WMD) with 95% confidence intervals (CIs). We collected individual trial data and conducted a meta-analysis to compare changes in global left ventricular ejection fraction (ÎLVEF) after stem cell therapy. In this study, four subgroups were based on stem cell dose (â¤1Â ÃÂ 107Â cells, â¤1Â ÃÂ 108Â cells, â¤1Â ÃÂ 109Â cells, and â¤1Â ÃÂ 1010Â cells) and three subgroups were based on follow-up time (<6 months, 6â12 months, and â¥12 months). Results: Thirty-four studies, which included 40 randomized controlled trials, were included in this meta-analysis, and 1927 patients were evaluated. Changes in global LVEF were significantly higher in the stem cell transplantation group than in the control group (95% CI: 2.35â4.26%, PÂ <Â 0.01). We found no significant differences in ÎLVEF between the bone marrow stem cells (BMCs) group and control group when the dose of BMCs was â¤1Â ÃÂ 107 [ÎLVEF 95% CI: 0.12â3.96%, PÂ =Â 0.04]. The ÎLVEF in the BMCs groups was significantly higher than in the control groups when the dose of BMCs was â¤1Â ÃÂ 108 [ÎLVEF 95% CI: 0.95â4.25%, PÂ =Â 0.002] and â¤1Â ÃÂ 109 [ÎLVEF 95% CI:Â 2.31â4.20%, PÂ <Â 0.01]. In addition, when the dose of BMCs was between 109 and 1010 cells, we did not observe any significant differences [ÎLVEF 95% CI: â0.99â11.82%, PÂ =Â 0.10]. Our data suggest stem cell therapy improves cardiac function in AMI patients when treated with an appropriate dose of BMCs. Conclusion: Stem cell transplantation after AMI could improve global LVEF. Stem cells may be effectively administered to patients with AMI doses between 108 and 109 cells. Keywords: Stem cell, Acute myocardial infarction, Left ventricular ejection fraction, Cell dosageJia-Ying XuWen-Yuan CaiMing TianDai LiuRong-Chong HuangKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 2, Iss 2, Pp 92-101 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Jia-Ying Xu Wen-Yuan Cai Ming Tian Dai Liu Rong-Chong Huang Stem cell transplantation dose in patients with acute myocardial infarction: A meta-analysis
description	Objective: To evaluate whether stem cell transplantation improves global left ventricular ejection fraction (LVEF) in patients with acute myocardial infarction (AMI), and to determine the appropriate stem cell therapy dose as well as the effective period after stem cell transplantation for therapy. Methods: A systematic literature search included Pubmed, MEDLINE, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), and Cochrane Evidence-Based Medicine databases. The retrieval time limit ranged from January 1990 to June 2016. We also obtained full texts through manual retrieval, interlibrary loan and document delivery service, or by contacting the authors directly. According to our inclusion and exclusion criteria, data were extracted independently by two evaluators. In case of disagreement, a joint discussion occurred and a third researcher was utilized. Data were analyzed quantitatively using Revman 5.2. Summary results are presented as the weighted mean difference (WMD) with 95% confidence intervals (CIs). We collected individual trial data and conducted a meta-analysis to compare changes in global left ventricular ejection fraction (ÎLVEF) after stem cell therapy. In this study, four subgroups were based on stem cell dose (â¤1Â ÃÂ 107Â cells, â¤1Â ÃÂ 108Â cells, â¤1Â ÃÂ 109Â cells, and â¤1Â ÃÂ 1010Â cells) and three subgroups were based on follow-up time (<6 months, 6â12 months, and â¥12 months). Results: Thirty-four studies, which included 40 randomized controlled trials, were included in this meta-analysis, and 1927 patients were evaluated. Changes in global LVEF were significantly higher in the stem cell transplantation group than in the control group (95% CI: 2.35â4.26%, PÂ <Â 0.01). We found no significant differences in ÎLVEF between the bone marrow stem cells (BMCs) group and control group when the dose of BMCs was â¤1Â ÃÂ 107 [ÎLVEF 95% CI: 0.12â3.96%, PÂ =Â 0.04]. The ÎLVEF in the BMCs groups was significantly higher than in the control groups when the dose of BMCs was â¤1Â ÃÂ 108 [ÎLVEF 95% CI: 0.95â4.25%, PÂ =Â 0.002] and â¤1Â ÃÂ 109 [ÎLVEF 95% CI:Â 2.31â4.20%, PÂ <Â 0.01]. In addition, when the dose of BMCs was between 109 and 1010 cells, we did not observe any significant differences [ÎLVEF 95% CI: â0.99â11.82%, PÂ =Â 0.10]. Our data suggest stem cell therapy improves cardiac function in AMI patients when treated with an appropriate dose of BMCs. Conclusion: Stem cell transplantation after AMI could improve global LVEF. Stem cells may be effectively administered to patients with AMI doses between 108 and 109 cells. Keywords: Stem cell, Acute myocardial infarction, Left ventricular ejection fraction, Cell dosage
format	article
author	Jia-Ying Xu Wen-Yuan Cai Ming Tian Dai Liu Rong-Chong Huang
author_facet	Jia-Ying Xu Wen-Yuan Cai Ming Tian Dai Liu Rong-Chong Huang
author_sort	Jia-Ying Xu
title	Stem cell transplantation dose in patients with acute myocardial infarction: A meta-analysis
title_short	Stem cell transplantation dose in patients with acute myocardial infarction: A meta-analysis
title_full	Stem cell transplantation dose in patients with acute myocardial infarction: A meta-analysis
title_fullStr	Stem cell transplantation dose in patients with acute myocardial infarction: A meta-analysis
title_full_unstemmed	Stem cell transplantation dose in patients with acute myocardial infarction: A meta-analysis
title_sort	stem cell transplantation dose in patients with acute myocardial infarction: a meta-analysis
publisher	KeAi Communications Co., Ltd.
publishDate	2016
url	https://doaj.org/article/5ccacde413b44f01b7926c2aac07a93d
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Stem cell transplantation dose in patients with acute myocardial infarction: A meta-analysis

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