The association between fat-to-muscle ratio and metabolic disorders in type 2 diabetes

Abstract Background Altered body composition is known to be related to abnormal metabolism. The aim of this study was to determine the association between the fat-to-muscle ratio (FMR) and metabolic disorders in type 2 diabetes (T2DM) population. Method In total, 361 T2DM participants aged ≥ 18 year...

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Autores principales:	Dixing Liu, Jiana Zhong, Yuting Ruan, Zhen Zhang, Jia Sun, Hong Chen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Type 2 diabetes mellitus Fat-to-muscle ratio Metabolic disorders Body composition Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/5ccca2d0733c4437be3e57103d6173c3
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spelling	oai:doaj.org-article:5ccca2d0733c4437be3e57103d6173c32021-11-14T12:38:53ZThe association between fat-to-muscle ratio and metabolic disorders in type 2 diabetes10.1186/s13098-021-00748-y1758-5996https://doaj.org/article/5ccca2d0733c4437be3e57103d6173c32021-11-01T00:00:00Zhttps://doi.org/10.1186/s13098-021-00748-yhttps://doaj.org/toc/1758-5996Abstract Background Altered body composition is known to be related to abnormal metabolism. The aim of this study was to determine the association between the fat-to-muscle ratio (FMR) and metabolic disorders in type 2 diabetes (T2DM) population. Method In total, 361 T2DM participants aged ≥ 18 years were included in our research. A bioelectrical impedance analyzer was applied to measure fat mass and muscle mass. FMR was calculated as body fat mass (kg) divided by muscle mass (kg). The performance of FMR to assess metabolic disorders in T2DM was conducted using ROC curves. The independent association between FMR and metabolic syndrome (MS) was tested by logistic regression analysis. Results The FMR was significantly higher in patients with MS than in those without MS (p < 0.001). The optimal FMR cutoff point for identifying MS was higher in females than in males (0.465 vs. 0.296, respectively). In addition, the areas under the ROC curve (AUCs) for the evaluation of MS by FMR, fat mass, muscle mass, BMI and waist circumference were further compared, indicating that the AUC of FMR (0.843) was the largest among the five variables in females, but the AUC of waist circumference (0.837) was still the largest among other variables in males. Based on the derived FMR cutoff point, patients with a high FMR exhibited more cardiometabolic risk indicators (all p < 0.05). Using a low FMR as a reference, the relative risk of a high FMR for MS was 2.861 (95% CI 1.111–7.368, p = 0.029) in males and 9.518 (95% CI 2.615–34.638, p = 0.001) in females following adjustment for confounding factors. Conclusions The fat-to-muscle ratio is independently and positively associated with metabolic disorders in T2DM. FMR may serve as an optimal method for screening T2DM patients coupled with a high risk of abnormal metabolism, especially in females, providing a new perspective for the prevention and treatment of cardiovascular complications in Chinese type 2 diabetes.Dixing LiuJiana ZhongYuting RuanZhen ZhangJia SunHong ChenBMCarticleType 2 diabetes mellitusFat-to-muscle ratioMetabolic disordersBody compositionNutritional diseases. Deficiency diseasesRC620-627ENDiabetology & Metabolic Syndrome, Vol 13, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Type 2 diabetes mellitus Fat-to-muscle ratio Metabolic disorders Body composition Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	Type 2 diabetes mellitus Fat-to-muscle ratio Metabolic disorders Body composition Nutritional diseases. Deficiency diseases RC620-627 Dixing Liu Jiana Zhong Yuting Ruan Zhen Zhang Jia Sun Hong Chen The association between fat-to-muscle ratio and metabolic disorders in type 2 diabetes
description	Abstract Background Altered body composition is known to be related to abnormal metabolism. The aim of this study was to determine the association between the fat-to-muscle ratio (FMR) and metabolic disorders in type 2 diabetes (T2DM) population. Method In total, 361 T2DM participants aged ≥ 18 years were included in our research. A bioelectrical impedance analyzer was applied to measure fat mass and muscle mass. FMR was calculated as body fat mass (kg) divided by muscle mass (kg). The performance of FMR to assess metabolic disorders in T2DM was conducted using ROC curves. The independent association between FMR and metabolic syndrome (MS) was tested by logistic regression analysis. Results The FMR was significantly higher in patients with MS than in those without MS (p < 0.001). The optimal FMR cutoff point for identifying MS was higher in females than in males (0.465 vs. 0.296, respectively). In addition, the areas under the ROC curve (AUCs) for the evaluation of MS by FMR, fat mass, muscle mass, BMI and waist circumference were further compared, indicating that the AUC of FMR (0.843) was the largest among the five variables in females, but the AUC of waist circumference (0.837) was still the largest among other variables in males. Based on the derived FMR cutoff point, patients with a high FMR exhibited more cardiometabolic risk indicators (all p < 0.05). Using a low FMR as a reference, the relative risk of a high FMR for MS was 2.861 (95% CI 1.111–7.368, p = 0.029) in males and 9.518 (95% CI 2.615–34.638, p = 0.001) in females following adjustment for confounding factors. Conclusions The fat-to-muscle ratio is independently and positively associated with metabolic disorders in T2DM. FMR may serve as an optimal method for screening T2DM patients coupled with a high risk of abnormal metabolism, especially in females, providing a new perspective for the prevention and treatment of cardiovascular complications in Chinese type 2 diabetes.
format	article
author	Dixing Liu Jiana Zhong Yuting Ruan Zhen Zhang Jia Sun Hong Chen
author_facet	Dixing Liu Jiana Zhong Yuting Ruan Zhen Zhang Jia Sun Hong Chen
author_sort	Dixing Liu
title	The association between fat-to-muscle ratio and metabolic disorders in type 2 diabetes
title_short	The association between fat-to-muscle ratio and metabolic disorders in type 2 diabetes
title_full	The association between fat-to-muscle ratio and metabolic disorders in type 2 diabetes
title_fullStr	The association between fat-to-muscle ratio and metabolic disorders in type 2 diabetes
title_full_unstemmed	The association between fat-to-muscle ratio and metabolic disorders in type 2 diabetes
title_sort	association between fat-to-muscle ratio and metabolic disorders in type 2 diabetes
publisher	BMC
publishDate	2021
url	https://doaj.org/article/5ccca2d0733c4437be3e57103d6173c3
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The association between fat-to-muscle ratio and metabolic disorders in type 2 diabetes

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