Joint effect of 25-hydroxyvitamin D and secondhand smoke exposure on hypertension in non-smoking women of childbearing age: NHANES 2007-2014

Abstract Background Vitamin D deficiency (VDD) may increase the risk of hypertension in women of childbearing age, who may be exposed to secondhand smoke (SHS) simultaneously. Till now, few studies have investigated the joint effects of VDD and SHS on hypertension in this population. We evaluated wh...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Qianqian Shen, Qian Xu, Guoju Li, Lisheng Ren, Zhenhong Zhang, Yangting Zhang, Zhaoyi Zhong, Xiaona Li, Qiuzhen Wang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	25-hydroxyvitamin D Secondhand smoke Hypertension Women of childbearing age Interaction Industrial medicine. Industrial hygiene RC963-969 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/5ccd3368d5af405e9f7a2a79b8919008
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5ccd3368d5af405e9f7a2a79b8919008
record_format	dspace
spelling	oai:doaj.org-article:5ccd3368d5af405e9f7a2a79b89190082021-11-21T12:33:11ZJoint effect of 25-hydroxyvitamin D and secondhand smoke exposure on hypertension in non-smoking women of childbearing age: NHANES 2007-201410.1186/s12940-021-00803-11476-069Xhttps://doaj.org/article/5ccd3368d5af405e9f7a2a79b89190082021-11-01T00:00:00Zhttps://doi.org/10.1186/s12940-021-00803-1https://doaj.org/toc/1476-069XAbstract Background Vitamin D deficiency (VDD) may increase the risk of hypertension in women of childbearing age, who may be exposed to secondhand smoke (SHS) simultaneously. Till now, few studies have investigated the joint effects of VDD and SHS on hypertension in this population. We evaluated whether exposure to SHS modified the association between VDD and hypertension. Methods Data from National Health and Nutrition Examination Surveys (NHANES) 2007-2014 were analyzed. Our research subjects were 2826 nonsmoking and nonpregnant women of childbearing age (20-44 years old). Hypertension was defined based either on systolic blood pressure (SBP) ≥ 130 mmHg and/or diastolic blood pressure (DBP) ≥ 80 mmHg or on now taking prescribed medicine for hypertension. The directed acyclic graphs (DAG) and the back-door criterion were used to select a minimal sufficient adjustment set of variables (MSAs) that would identify the unconfounded effect of 25(OH)D and hypertension. The interactive effect of VDD and SHS on hypertension was evaluated by using logistic regression models, followed by strata-specific analyses. Results The prevalence of VDD in the hypertension group was significantly higher than that in the non-hypertension group (48.2% vs 41.0%, P = 0.008), as well as the exposure rate of SHS (39.1% vs 33.8%, P = 0.017). VDD was independently associated with nearly 50% increased risk of hypertension [adjusted odds ratio (aOR) = 1.43, 95% confidence interval (CI): 1.01, 2.04], while no significant association was observed between SHS and hypertension. However, SHS showed a significant synergistic effect on VDD with a higher aOR of 1.79 (95% CI: 1.14, 2.80) (P interaction = 0.011). This synergistic effect was more obvious when stratified by BMI (in overweight women, aOR, 95% CI =4.74, 1.65-13.60 for interaction vs 2.33, 1.01-5.38 for VDD only) and race (in Non-Hispanic Black women, aOR, 95% CI =5.11, 1.58-16.54 for interaction vs 2.69, 1.10-6.62 for VDD only). Conclusion There exist synergistic effects of SHS and VDD on the prevalence of hypertension in American women of childbearing age, with more significant effects in women who were overweight or Non-Hispanic Black. Further studies are warranted to verify this finding in other populations, and the molecular mechanisms underlying the joint effect of SHS and VDD need to be elucidated.Qianqian ShenQian XuGuoju LiLisheng RenZhenhong ZhangYangting ZhangZhaoyi ZhongXiaona LiQiuzhen WangBMCarticle25-hydroxyvitamin DSecondhand smokeHypertensionWomen of childbearing ageInteractionIndustrial medicine. Industrial hygieneRC963-969Public aspects of medicineRA1-1270ENEnvironmental Health, Vol 20, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	25-hydroxyvitamin D Secondhand smoke Hypertension Women of childbearing age Interaction Industrial medicine. Industrial hygiene RC963-969 Public aspects of medicine RA1-1270
spellingShingle	25-hydroxyvitamin D Secondhand smoke Hypertension Women of childbearing age Interaction Industrial medicine. Industrial hygiene RC963-969 Public aspects of medicine RA1-1270 Qianqian Shen Qian Xu Guoju Li Lisheng Ren Zhenhong Zhang Yangting Zhang Zhaoyi Zhong Xiaona Li Qiuzhen Wang Joint effect of 25-hydroxyvitamin D and secondhand smoke exposure on hypertension in non-smoking women of childbearing age: NHANES 2007-2014
description	Abstract Background Vitamin D deficiency (VDD) may increase the risk of hypertension in women of childbearing age, who may be exposed to secondhand smoke (SHS) simultaneously. Till now, few studies have investigated the joint effects of VDD and SHS on hypertension in this population. We evaluated whether exposure to SHS modified the association between VDD and hypertension. Methods Data from National Health and Nutrition Examination Surveys (NHANES) 2007-2014 were analyzed. Our research subjects were 2826 nonsmoking and nonpregnant women of childbearing age (20-44 years old). Hypertension was defined based either on systolic blood pressure (SBP) ≥ 130 mmHg and/or diastolic blood pressure (DBP) ≥ 80 mmHg or on now taking prescribed medicine for hypertension. The directed acyclic graphs (DAG) and the back-door criterion were used to select a minimal sufficient adjustment set of variables (MSAs) that would identify the unconfounded effect of 25(OH)D and hypertension. The interactive effect of VDD and SHS on hypertension was evaluated by using logistic regression models, followed by strata-specific analyses. Results The prevalence of VDD in the hypertension group was significantly higher than that in the non-hypertension group (48.2% vs 41.0%, P = 0.008), as well as the exposure rate of SHS (39.1% vs 33.8%, P = 0.017). VDD was independently associated with nearly 50% increased risk of hypertension [adjusted odds ratio (aOR) = 1.43, 95% confidence interval (CI): 1.01, 2.04], while no significant association was observed between SHS and hypertension. However, SHS showed a significant synergistic effect on VDD with a higher aOR of 1.79 (95% CI: 1.14, 2.80) (P interaction = 0.011). This synergistic effect was more obvious when stratified by BMI (in overweight women, aOR, 95% CI =4.74, 1.65-13.60 for interaction vs 2.33, 1.01-5.38 for VDD only) and race (in Non-Hispanic Black women, aOR, 95% CI =5.11, 1.58-16.54 for interaction vs 2.69, 1.10-6.62 for VDD only). Conclusion There exist synergistic effects of SHS and VDD on the prevalence of hypertension in American women of childbearing age, with more significant effects in women who were overweight or Non-Hispanic Black. Further studies are warranted to verify this finding in other populations, and the molecular mechanisms underlying the joint effect of SHS and VDD need to be elucidated.
format	article
author	Qianqian Shen Qian Xu Guoju Li Lisheng Ren Zhenhong Zhang Yangting Zhang Zhaoyi Zhong Xiaona Li Qiuzhen Wang
author_facet	Qianqian Shen Qian Xu Guoju Li Lisheng Ren Zhenhong Zhang Yangting Zhang Zhaoyi Zhong Xiaona Li Qiuzhen Wang
author_sort	Qianqian Shen
title	Joint effect of 25-hydroxyvitamin D and secondhand smoke exposure on hypertension in non-smoking women of childbearing age: NHANES 2007-2014
title_short	Joint effect of 25-hydroxyvitamin D and secondhand smoke exposure on hypertension in non-smoking women of childbearing age: NHANES 2007-2014
title_full	Joint effect of 25-hydroxyvitamin D and secondhand smoke exposure on hypertension in non-smoking women of childbearing age: NHANES 2007-2014
title_fullStr	Joint effect of 25-hydroxyvitamin D and secondhand smoke exposure on hypertension in non-smoking women of childbearing age: NHANES 2007-2014
title_full_unstemmed	Joint effect of 25-hydroxyvitamin D and secondhand smoke exposure on hypertension in non-smoking women of childbearing age: NHANES 2007-2014
title_sort	joint effect of 25-hydroxyvitamin d and secondhand smoke exposure on hypertension in non-smoking women of childbearing age: nhanes 2007-2014
publisher	BMC
publishDate	2021
url	https://doaj.org/article/5ccd3368d5af405e9f7a2a79b8919008
work_keys_str_mv	AT qianqianshen jointeffectof25hydroxyvitamindandsecondhandsmokeexposureonhypertensioninnonsmokingwomenofchildbearingagenhanes20072014 AT qianxu jointeffectof25hydroxyvitamindandsecondhandsmokeexposureonhypertensioninnonsmokingwomenofchildbearingagenhanes20072014 AT guojuli jointeffectof25hydroxyvitamindandsecondhandsmokeexposureonhypertensioninnonsmokingwomenofchildbearingagenhanes20072014 AT lishengren jointeffectof25hydroxyvitamindandsecondhandsmokeexposureonhypertensioninnonsmokingwomenofchildbearingagenhanes20072014 AT zhenhongzhang jointeffectof25hydroxyvitamindandsecondhandsmokeexposureonhypertensioninnonsmokingwomenofchildbearingagenhanes20072014 AT yangtingzhang jointeffectof25hydroxyvitamindandsecondhandsmokeexposureonhypertensioninnonsmokingwomenofchildbearingagenhanes20072014 AT zhaoyizhong jointeffectof25hydroxyvitamindandsecondhandsmokeexposureonhypertensioninnonsmokingwomenofchildbearingagenhanes20072014 AT xiaonali jointeffectof25hydroxyvitamindandsecondhandsmokeexposureonhypertensioninnonsmokingwomenofchildbearingagenhanes20072014 AT qiuzhenwang jointeffectof25hydroxyvitamindandsecondhandsmokeexposureonhypertensioninnonsmokingwomenofchildbearingagenhanes20072014
_version_	1718418945478754304

Joint effect of 25-hydroxyvitamin D and secondhand smoke exposure on hypertension in non-smoking women of childbearing age: NHANES 2007-2014

Ejemplares similares