Could Reducing Body Fatness Reduce the Risk of Aggressive Prostate Cancer via the Insulin Signalling Pathway? A Systematic Review of the Mechanistic Pathway

Excess body weight is thought to increase the risk of aggressive prostate cancer (PCa), although the biological mechanism is currently unclear. Body fatness is positively associated with a diminished cellular response to insulin and biomarkers of insulin signalling have been positively associated wi...

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Autores principales:	Rachel James, Olympia Dimopoulou, Richard M. Martin, Claire M. Perks, Claire Kelly, Louise Mathias, Stefan Brugger, Julian P. T. Higgins, Sarah J. Lewis
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	body fatness prostate cancer biomarker insulin insulin signalling mechanisms Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/5ccd3efcf43148d0abb8d35c7c7b07e4
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spelling	oai:doaj.org-article:5ccd3efcf43148d0abb8d35c7c7b07e42021-11-25T18:20:29ZCould Reducing Body Fatness Reduce the Risk of Aggressive Prostate Cancer via the Insulin Signalling Pathway? A Systematic Review of the Mechanistic Pathway10.3390/metabo111107262218-1989https://doaj.org/article/5ccd3efcf43148d0abb8d35c7c7b07e42021-10-01T00:00:00Zhttps://www.mdpi.com/2218-1989/11/11/726https://doaj.org/toc/2218-1989Excess body weight is thought to increase the risk of aggressive prostate cancer (PCa), although the biological mechanism is currently unclear. Body fatness is positively associated with a diminished cellular response to insulin and biomarkers of insulin signalling have been positively associated with PCa risk. We carried out a two-pronged systematic review of (a) the effect of reducing body fatness on insulin biomarker levels and (b) the effect of insulin biomarkers on PCa risk, to determine whether a reduction in body fatness could reduce PCa risk via effects on the insulin signalling pathway. We identified seven eligible randomised controlled trials of interventions designed to reduce body fatness which measured insulin biomarkers as an outcome, and six eligible prospective observational studies of insulin biomarkers and PCa risk. We found some evidence that a reduction in body fatness improved insulin sensitivity although our confidence in this evidence was low based on GRADE (Grading of Recommendations, Assessment, Development and Evaluations). We were unable to reach any conclusions on the effect of insulin sensitivity on PCa risk from the few studies included in our systematic review. A reduction in body fatness may reduce PCa risk via insulin signalling, but more high-quality evidence is needed before any conclusions can be reached regarding PCa.Rachel JamesOlympia DimopoulouRichard M. MartinClaire M. PerksClaire KellyLouise MathiasStefan BruggerJulian P. T. HigginsSarah J. LewisMDPI AGarticlebody fatnessprostate cancerbiomarkerinsulininsulin signallingmechanismsMicrobiologyQR1-502ENMetabolites, Vol 11, Iss 726, p 726 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	body fatness prostate cancer biomarker insulin insulin signalling mechanisms Microbiology QR1-502
spellingShingle	body fatness prostate cancer biomarker insulin insulin signalling mechanisms Microbiology QR1-502 Rachel James Olympia Dimopoulou Richard M. Martin Claire M. Perks Claire Kelly Louise Mathias Stefan Brugger Julian P. T. Higgins Sarah J. Lewis Could Reducing Body Fatness Reduce the Risk of Aggressive Prostate Cancer via the Insulin Signalling Pathway? A Systematic Review of the Mechanistic Pathway
description	Excess body weight is thought to increase the risk of aggressive prostate cancer (PCa), although the biological mechanism is currently unclear. Body fatness is positively associated with a diminished cellular response to insulin and biomarkers of insulin signalling have been positively associated with PCa risk. We carried out a two-pronged systematic review of (a) the effect of reducing body fatness on insulin biomarker levels and (b) the effect of insulin biomarkers on PCa risk, to determine whether a reduction in body fatness could reduce PCa risk via effects on the insulin signalling pathway. We identified seven eligible randomised controlled trials of interventions designed to reduce body fatness which measured insulin biomarkers as an outcome, and six eligible prospective observational studies of insulin biomarkers and PCa risk. We found some evidence that a reduction in body fatness improved insulin sensitivity although our confidence in this evidence was low based on GRADE (Grading of Recommendations, Assessment, Development and Evaluations). We were unable to reach any conclusions on the effect of insulin sensitivity on PCa risk from the few studies included in our systematic review. A reduction in body fatness may reduce PCa risk via insulin signalling, but more high-quality evidence is needed before any conclusions can be reached regarding PCa.
format	article
author	Rachel James Olympia Dimopoulou Richard M. Martin Claire M. Perks Claire Kelly Louise Mathias Stefan Brugger Julian P. T. Higgins Sarah J. Lewis
author_facet	Rachel James Olympia Dimopoulou Richard M. Martin Claire M. Perks Claire Kelly Louise Mathias Stefan Brugger Julian P. T. Higgins Sarah J. Lewis
author_sort	Rachel James
title	Could Reducing Body Fatness Reduce the Risk of Aggressive Prostate Cancer via the Insulin Signalling Pathway? A Systematic Review of the Mechanistic Pathway
title_short	Could Reducing Body Fatness Reduce the Risk of Aggressive Prostate Cancer via the Insulin Signalling Pathway? A Systematic Review of the Mechanistic Pathway
title_full	Could Reducing Body Fatness Reduce the Risk of Aggressive Prostate Cancer via the Insulin Signalling Pathway? A Systematic Review of the Mechanistic Pathway
title_fullStr	Could Reducing Body Fatness Reduce the Risk of Aggressive Prostate Cancer via the Insulin Signalling Pathway? A Systematic Review of the Mechanistic Pathway
title_full_unstemmed	Could Reducing Body Fatness Reduce the Risk of Aggressive Prostate Cancer via the Insulin Signalling Pathway? A Systematic Review of the Mechanistic Pathway
title_sort	could reducing body fatness reduce the risk of aggressive prostate cancer via the insulin signalling pathway? a systematic review of the mechanistic pathway
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5ccd3efcf43148d0abb8d35c7c7b07e4
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Could Reducing Body Fatness Reduce the Risk of Aggressive Prostate Cancer via the Insulin Signalling Pathway? A Systematic Review of the Mechanistic Pathway

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