Could Reducing Body Fatness Reduce the Risk of Aggressive Prostate Cancer via the Insulin Signalling Pathway? A Systematic Review of the Mechanistic Pathway

Could Reducing Body Fatness Reduce the Risk of Aggressive Prostate Cancer via the Insulin Signalling Pathway? A Systematic Review of the Mechanistic Pathway

Excess body weight is thought to increase the risk of aggressive prostate cancer (PCa), although the biological mechanism is currently unclear. Body fatness is positively associated with a diminished cellular response to insulin and biomarkers of insulin signalling have been positively associated wi...

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Bibliographic Details
Main Authors: Rachel James, Olympia Dimopoulou, Richard M. Martin, Claire M. Perks, Claire Kelly, Louise Mathias, Stefan Brugger, Julian P. T. Higgins, Sarah J. Lewis
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
body fatness
prostate cancer
biomarker
insulin
insulin signalling
mechanisms
Microbiology
QR1-502
Online Access:https://doaj.org/article/5ccd3efcf43148d0abb8d35c7c7b07e4
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https://doaj.org/article/5ccd3efcf43148d0abb8d35c7c7b07e4

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