Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease

B cells are important for antigen presentation and antibody production in humoral immunity, but are also increasingly recognized for their immune regulatory functions. Here the authors show that HIF-1α, a hypoxia-induced transcription factor, is important for controlling IL-10 induction in and immun...

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Autores principales:	Xianyi Meng, Bettina Grötsch, Yubin Luo, Karl Xaver Knaup, Michael Sean Wiesener, Xiao-Xiang Chen, Jonathan Jantsch, Simon Fillatreau, Georg Schett, Aline Bozec
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5ccd5d39b25f4edd9af12b6f1ad0ddfa
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spelling	oai:doaj.org-article:5ccd5d39b25f4edd9af12b6f1ad0ddfa2021-12-02T17:31:43ZHypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease10.1038/s41467-017-02683-x2041-1723https://doaj.org/article/5ccd5d39b25f4edd9af12b6f1ad0ddfa2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02683-xhttps://doaj.org/toc/2041-1723B cells are important for antigen presentation and antibody production in humoral immunity, but are also increasingly recognized for their immune regulatory functions. Here the authors show that HIF-1α, a hypoxia-induced transcription factor, is important for controlling IL-10 induction in and immune-suppressive activity of B cells.Xianyi MengBettina GrötschYubin LuoKarl Xaver KnaupMichael Sean WiesenerXiao-Xiang ChenJonathan JantschSimon FillatreauGeorg SchettAline BozecNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xianyi Meng Bettina Grötsch Yubin Luo Karl Xaver Knaup Michael Sean Wiesener Xiao-Xiang Chen Jonathan Jantsch Simon Fillatreau Georg Schett Aline Bozec Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease
description	B cells are important for antigen presentation and antibody production in humoral immunity, but are also increasingly recognized for their immune regulatory functions. Here the authors show that HIF-1α, a hypoxia-induced transcription factor, is important for controlling IL-10 induction in and immune-suppressive activity of B cells.
format	article
author	Xianyi Meng Bettina Grötsch Yubin Luo Karl Xaver Knaup Michael Sean Wiesener Xiao-Xiang Chen Jonathan Jantsch Simon Fillatreau Georg Schett Aline Bozec
author_facet	Xianyi Meng Bettina Grötsch Yubin Luo Karl Xaver Knaup Michael Sean Wiesener Xiao-Xiang Chen Jonathan Jantsch Simon Fillatreau Georg Schett Aline Bozec
author_sort	Xianyi Meng
title	Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease
title_short	Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease
title_full	Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease
title_fullStr	Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease
title_full_unstemmed	Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease
title_sort	hypoxia-inducible factor-1α is a critical transcription factor for il-10-producing b cells in autoimmune disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5ccd5d39b25f4edd9af12b6f1ad0ddfa
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Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease

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