Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti

The adult mammalian cochlear sensory epithelium consists of mechanosensory hair cells and supporting cells but hair cells cannot regenerate. Here, the authors identify multipotent progenitors that arise fromEya1-expressing otic cells that can regenerate hair cells in mice after 1 week of age.

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Auteurs principaux:	Jinshu Xu, Hiroo Ueno, Chelsea Y. Xu, Binglai Chen, Irving L. Weissman, Pin-Xian Xu
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/5cd0e2b5a4a4481b8d6ad089c0a2794f
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spelling	oai:doaj.org-article:5cd0e2b5a4a4481b8d6ad089c0a2794f2021-12-02T14:42:22ZIdentification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti10.1038/ncomms150462041-1723https://doaj.org/article/5cd0e2b5a4a4481b8d6ad089c0a2794f2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15046https://doaj.org/toc/2041-1723The adult mammalian cochlear sensory epithelium consists of mechanosensory hair cells and supporting cells but hair cells cannot regenerate. Here, the authors identify multipotent progenitors that arise fromEya1-expressing otic cells that can regenerate hair cells in mice after 1 week of age.Jinshu XuHiroo UenoChelsea Y. XuBinglai ChenIrving L. WeissmanPin-Xian XuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinshu Xu Hiroo Ueno Chelsea Y. Xu Binglai Chen Irving L. Weissman Pin-Xian Xu Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti
description	The adult mammalian cochlear sensory epithelium consists of mechanosensory hair cells and supporting cells but hair cells cannot regenerate. Here, the authors identify multipotent progenitors that arise fromEya1-expressing otic cells that can regenerate hair cells in mice after 1 week of age.
format	article
author	Jinshu Xu Hiroo Ueno Chelsea Y. Xu Binglai Chen Irving L. Weissman Pin-Xian Xu
author_facet	Jinshu Xu Hiroo Ueno Chelsea Y. Xu Binglai Chen Irving L. Weissman Pin-Xian Xu
author_sort	Jinshu Xu
title	Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti
title_short	Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti
title_full	Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti
title_fullStr	Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti
title_full_unstemmed	Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti
title_sort	identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of corti
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5cd0e2b5a4a4481b8d6ad089c0a2794f
work_keys_str_mv	AT jinshuxu identificationofmousecochlearprogenitorsthatdevelophairandsupportingcellsintheorganofcorti AT hirooueno identificationofmousecochlearprogenitorsthatdevelophairandsupportingcellsintheorganofcorti AT chelseayxu identificationofmousecochlearprogenitorsthatdevelophairandsupportingcellsintheorganofcorti AT binglaichen identificationofmousecochlearprogenitorsthatdevelophairandsupportingcellsintheorganofcorti AT irvinglweissman identificationofmousecochlearprogenitorsthatdevelophairandsupportingcellsintheorganofcorti AT pinxianxu identificationofmousecochlearprogenitorsthatdevelophairandsupportingcellsintheorganofcorti
_version_	1718389690618347520

Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti

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