An axon-specific expression of HCN channels catalyzes fast action potential signaling in GABAergic interneurons

The precise subcellular location of ion channels is a key determinant of their functions. Here, subcellular patch-clamp recordings demonstrate that an axon-specific expression of HCN channels facilitates the initiation and propagation of action potentials in parvalbumin-expressing basket cells.

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Autores principales:	Fabian C. Roth, Hua Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5cd212d0516e4b68899ac93191b93245
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spelling	oai:doaj.org-article:5cd212d0516e4b68899ac93191b932452021-12-02T15:37:16ZAn axon-specific expression of HCN channels catalyzes fast action potential signaling in GABAergic interneurons10.1038/s41467-020-15791-y2041-1723https://doaj.org/article/5cd212d0516e4b68899ac93191b932452020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15791-yhttps://doaj.org/toc/2041-1723The precise subcellular location of ion channels is a key determinant of their functions. Here, subcellular patch-clamp recordings demonstrate that an axon-specific expression of HCN channels facilitates the initiation and propagation of action potentials in parvalbumin-expressing basket cells.Fabian C. RothHua HuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fabian C. Roth Hua Hu An axon-specific expression of HCN channels catalyzes fast action potential signaling in GABAergic interneurons
description	The precise subcellular location of ion channels is a key determinant of their functions. Here, subcellular patch-clamp recordings demonstrate that an axon-specific expression of HCN channels facilitates the initiation and propagation of action potentials in parvalbumin-expressing basket cells.
format	article
author	Fabian C. Roth Hua Hu
author_facet	Fabian C. Roth Hua Hu
author_sort	Fabian C. Roth
title	An axon-specific expression of HCN channels catalyzes fast action potential signaling in GABAergic interneurons
title_short	An axon-specific expression of HCN channels catalyzes fast action potential signaling in GABAergic interneurons
title_full	An axon-specific expression of HCN channels catalyzes fast action potential signaling in GABAergic interneurons
title_fullStr	An axon-specific expression of HCN channels catalyzes fast action potential signaling in GABAergic interneurons
title_full_unstemmed	An axon-specific expression of HCN channels catalyzes fast action potential signaling in GABAergic interneurons
title_sort	axon-specific expression of hcn channels catalyzes fast action potential signaling in gabaergic interneurons
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5cd212d0516e4b68899ac93191b93245
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An axon-specific expression of HCN channels catalyzes fast action potential signaling in GABAergic interneurons

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