Gray Matter Density of the Dorsomedial Prefrontal Cortex Mediates the Relationship Between Catastrophizing and Anxiety in Somatic Symptom Disorder

Xiandi Pan,1,* Weina Ding,2,* Xia Sun,3,* Chenfeng Ji,3 Qian Zhou,3 Chao Yan,4 Yan Zhou,2 Yanli Luo3 1Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai, People’s Republic of China; 2Department of Radiology, Renji Hospital, Shanghai Jiaotong University Sch...

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Autores principales:	Pan X, Ding W, Sun X, Ji C, Zhou Q, Yan C, Zhou Y, Luo Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	somatic symptom disorder dorsomedial prefrontal cortex catastrophizing anxiety mediating effect. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5cd4907ce70644288377f73076f7a03a
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spelling	oai:doaj.org-article:5cd4907ce70644288377f73076f7a03a2021-12-02T17:09:43ZGray Matter Density of the Dorsomedial Prefrontal Cortex Mediates the Relationship Between Catastrophizing and Anxiety in Somatic Symptom Disorder1178-2021https://doaj.org/article/5cd4907ce70644288377f73076f7a03a2021-03-01T00:00:00Zhttps://www.dovepress.com/gray-matter-density-of-the-dorsomedial-prefrontal-cortex-mediates-the--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Xiandi Pan,1,* Weina Ding,2,* Xia Sun,3,* Chenfeng Ji,3 Qian Zhou,3 Chao Yan,4 Yan Zhou,2 Yanli Luo3 1Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai, People’s Republic of China; 2Department of Radiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China; 3Department of Psychological Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China; 4Key Laboratory of Brain Functional Genomics (MOE&STCSM), Shanghai Changning-ECNU Mental Health Center, School of Psychology and Cognitive Science, East China Normal University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yanli LuoDepartment of Psychological Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Pujian Road 160, Shanghai, 200127, People’s Republic of ChinaTel +86-21-68382998Email luoluoyanli@163.comYan ZhouDepartment of Radiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Pujian Road 160, Shanghai, 200127, People’s Republic of ChinaTel +86-21-68385105Email clare1475@hotmail.comObjective: Catastrophizing is commonly co-occurrence with anxiety in somatic symptom disorder (SSD). However, the quantitative relationship between catastrophizing and anxiety in SSD and its underlying neuropsychopathology remains unclear.Methods: To address the issue, twenty-eight SSD patients and twenty-nine healthy controls (HCs) completed the Hamilton anxiety scale and the catastrophizing subscale of the cognitive emotion regulation questionnaire. Then they underwent structural magnetic resonance imaging and voxel-based morphometry analysis was performed to obtain gray matter density (GMD) of the dorsomedial prefrontal cortex (dmPFC).Results: Independent samples t-tests showed no significance between SSD patients and HCs in the scores on the catastrophizing subscale and GMD of the dmPFC. However, correlation analysis found that catastrophizing was significantly positively associated with anxiety in SSD. Further, mediation analyses revealed that GMD of the dmPFC (bilateral medial Brodmann area 8) mediated the relationship between catastrophizing and anxiety in SSD.Conclusion: These findings support Kirmayer’s disease model of SSD that catastrophic interpretations of somatic symptoms resulted in increased anxiety and demonstrate that the dmPFC may be a potential neural site linking catastrophizing and anxiety in SSD.Keywords: somatic symptom disorder, dorsomedial prefrontal cortex, catastrophizing, anxiety, mediating effectPan XDing WSun XJi CZhou QYan CZhou YLuo YDove Medical Pressarticlesomatic symptom disorderdorsomedial prefrontal cortexcatastrophizinganxietymediating effect.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 757-764 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	somatic symptom disorder dorsomedial prefrontal cortex catastrophizing anxiety mediating effect. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	somatic symptom disorder dorsomedial prefrontal cortex catastrophizing anxiety mediating effect. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Pan X Ding W Sun X Ji C Zhou Q Yan C Zhou Y Luo Y Gray Matter Density of the Dorsomedial Prefrontal Cortex Mediates the Relationship Between Catastrophizing and Anxiety in Somatic Symptom Disorder
description	Xiandi Pan,1,* Weina Ding,2,* Xia Sun,3,* Chenfeng Ji,3 Qian Zhou,3 Chao Yan,4 Yan Zhou,2 Yanli Luo3 1Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai, People’s Republic of China; 2Department of Radiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China; 3Department of Psychological Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China; 4Key Laboratory of Brain Functional Genomics (MOE&STCSM), Shanghai Changning-ECNU Mental Health Center, School of Psychology and Cognitive Science, East China Normal University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yanli LuoDepartment of Psychological Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Pujian Road 160, Shanghai, 200127, People’s Republic of ChinaTel +86-21-68382998Email luoluoyanli@163.comYan ZhouDepartment of Radiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Pujian Road 160, Shanghai, 200127, People’s Republic of ChinaTel +86-21-68385105Email clare1475@hotmail.comObjective: Catastrophizing is commonly co-occurrence with anxiety in somatic symptom disorder (SSD). However, the quantitative relationship between catastrophizing and anxiety in SSD and its underlying neuropsychopathology remains unclear.Methods: To address the issue, twenty-eight SSD patients and twenty-nine healthy controls (HCs) completed the Hamilton anxiety scale and the catastrophizing subscale of the cognitive emotion regulation questionnaire. Then they underwent structural magnetic resonance imaging and voxel-based morphometry analysis was performed to obtain gray matter density (GMD) of the dorsomedial prefrontal cortex (dmPFC).Results: Independent samples t-tests showed no significance between SSD patients and HCs in the scores on the catastrophizing subscale and GMD of the dmPFC. However, correlation analysis found that catastrophizing was significantly positively associated with anxiety in SSD. Further, mediation analyses revealed that GMD of the dmPFC (bilateral medial Brodmann area 8) mediated the relationship between catastrophizing and anxiety in SSD.Conclusion: These findings support Kirmayer’s disease model of SSD that catastrophic interpretations of somatic symptoms resulted in increased anxiety and demonstrate that the dmPFC may be a potential neural site linking catastrophizing and anxiety in SSD.Keywords: somatic symptom disorder, dorsomedial prefrontal cortex, catastrophizing, anxiety, mediating effect
format	article
author	Pan X Ding W Sun X Ji C Zhou Q Yan C Zhou Y Luo Y
author_facet	Pan X Ding W Sun X Ji C Zhou Q Yan C Zhou Y Luo Y
author_sort	Pan X
title	Gray Matter Density of the Dorsomedial Prefrontal Cortex Mediates the Relationship Between Catastrophizing and Anxiety in Somatic Symptom Disorder
title_short	Gray Matter Density of the Dorsomedial Prefrontal Cortex Mediates the Relationship Between Catastrophizing and Anxiety in Somatic Symptom Disorder
title_full	Gray Matter Density of the Dorsomedial Prefrontal Cortex Mediates the Relationship Between Catastrophizing and Anxiety in Somatic Symptom Disorder
title_fullStr	Gray Matter Density of the Dorsomedial Prefrontal Cortex Mediates the Relationship Between Catastrophizing and Anxiety in Somatic Symptom Disorder
title_full_unstemmed	Gray Matter Density of the Dorsomedial Prefrontal Cortex Mediates the Relationship Between Catastrophizing and Anxiety in Somatic Symptom Disorder
title_sort	gray matter density of the dorsomedial prefrontal cortex mediates the relationship between catastrophizing and anxiety in somatic symptom disorder
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/5cd4907ce70644288377f73076f7a03a
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Gray Matter Density of the Dorsomedial Prefrontal Cortex Mediates the Relationship Between Catastrophizing and Anxiety in Somatic Symptom Disorder

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