Colorectal Cancer Progression Is Potently Reduced by a Glucose-Free, High-Protein Diet: Comparison to Anti-EGFR Therapy

Colorectal Cancer Progression Is Potently Reduced by a Glucose-Free, High-Protein Diet: Comparison to Anti-EGFR Therapy

To enable rapid proliferation, colorectal tumor cells up-regulate epidermal growth factor receptor (EGFR) signaling and aerobic glycolysis, resulting in substantial lactate release into the tumor microenvironment and impaired anti-tumor immune responses. We hypothesized that a nutritional interventi...

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Bibliographic Details
Main Authors: Kerstin Skibbe, Ann-Kathrin Brethack, Annika Sünderhauf, Mohab Ragab, Annika Raschdorf, Maren Hicken, Heidi Schlichting, Joyce Preira, Jennifer Brandt, Darko Castven, Bandik Föh, René Pagel, Jens U. Marquardt, Christian Sina, Stefanie Derer
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
EGFR
colorectal cancer
amino acid metabolism
PD-L1
PD-1
AOM/DSS
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/5cd64188174e4c99bfdca3d7276a666f
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https://doaj.org/article/5cd64188174e4c99bfdca3d7276a666f

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