Molecular subclassification of gastrointestinal cancers based on cancer stem cell traits

Abstract Human gastrointestinal malignancies are highly heterogeneous cancers. Clinically, heterogeneity largely contributes to tumor progression and resistance to therapy. Heterogeneity within gastrointestinal cancers is defined by molecular subtypes in genomic and transcriptomic analyses. Cancer s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mei-Mei Li, Jun Yuan, Xin-Yuan Guan, Ning-Fang Ma, Ming Liu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Gastrointestinal cancer Heterogeneity Cancer stem cell Cancer subtype Precision oncology Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/5cd65ad0364447f187fac285fb44c16d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5cd65ad0364447f187fac285fb44c16d
record_format	dspace
spelling	oai:doaj.org-article:5cd65ad0364447f187fac285fb44c16d2021-11-14T12:11:38ZMolecular subclassification of gastrointestinal cancers based on cancer stem cell traits10.1186/s40164-021-00246-x2162-3619https://doaj.org/article/5cd65ad0364447f187fac285fb44c16d2021-11-01T00:00:00Zhttps://doi.org/10.1186/s40164-021-00246-xhttps://doaj.org/toc/2162-3619Abstract Human gastrointestinal malignancies are highly heterogeneous cancers. Clinically, heterogeneity largely contributes to tumor progression and resistance to therapy. Heterogeneity within gastrointestinal cancers is defined by molecular subtypes in genomic and transcriptomic analyses. Cancer stem cells (CSCs) have been demonstrated to be a major source of tumor heterogeneity; therefore, assessing tumor heterogeneity by CSC trait-guided classification of gastrointestinal cancers is essential for the development of effective therapies. CSCs share critical features with embryonic stem cells (ESCs). Molecular investigations have revealed that embryonic genes and developmental signaling pathways regulating the properties of ESCs or cell lineage differentiation are abnormally active and might be oncofetal drivers in certain tumor subtypes. Currently, multiple strategies allow comprehensive identification of tumor subtype-specific oncofetal signatures and evaluation of subtype-specific therapies. In this review, we summarize current knowledge concerning the molecular classification of gastrointestinal malignancies based on CSC features and elucidate their clinical relevance. We also outline strategies for molecular subtype identification and subtype-based therapies. Finally, we explore how clinical implementation of tumor classification by CSC subtype might facilitate the development of more effective personalized therapies for gastrointestinal cancers.Mei-Mei LiJun YuanXin-Yuan GuanNing-Fang MaMing LiuBMCarticleGastrointestinal cancerHeterogeneityCancer stem cellCancer subtypePrecision oncologyDiseases of the blood and blood-forming organsRC633-647.5Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENExperimental Hematology & Oncology, Vol 10, Iss 1, Pp 1-23 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gastrointestinal cancer Heterogeneity Cancer stem cell Cancer subtype Precision oncology Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Gastrointestinal cancer Heterogeneity Cancer stem cell Cancer subtype Precision oncology Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Mei-Mei Li Jun Yuan Xin-Yuan Guan Ning-Fang Ma Ming Liu Molecular subclassification of gastrointestinal cancers based on cancer stem cell traits
description	Abstract Human gastrointestinal malignancies are highly heterogeneous cancers. Clinically, heterogeneity largely contributes to tumor progression and resistance to therapy. Heterogeneity within gastrointestinal cancers is defined by molecular subtypes in genomic and transcriptomic analyses. Cancer stem cells (CSCs) have been demonstrated to be a major source of tumor heterogeneity; therefore, assessing tumor heterogeneity by CSC trait-guided classification of gastrointestinal cancers is essential for the development of effective therapies. CSCs share critical features with embryonic stem cells (ESCs). Molecular investigations have revealed that embryonic genes and developmental signaling pathways regulating the properties of ESCs or cell lineage differentiation are abnormally active and might be oncofetal drivers in certain tumor subtypes. Currently, multiple strategies allow comprehensive identification of tumor subtype-specific oncofetal signatures and evaluation of subtype-specific therapies. In this review, we summarize current knowledge concerning the molecular classification of gastrointestinal malignancies based on CSC features and elucidate their clinical relevance. We also outline strategies for molecular subtype identification and subtype-based therapies. Finally, we explore how clinical implementation of tumor classification by CSC subtype might facilitate the development of more effective personalized therapies for gastrointestinal cancers.
format	article
author	Mei-Mei Li Jun Yuan Xin-Yuan Guan Ning-Fang Ma Ming Liu
author_facet	Mei-Mei Li Jun Yuan Xin-Yuan Guan Ning-Fang Ma Ming Liu
author_sort	Mei-Mei Li
title	Molecular subclassification of gastrointestinal cancers based on cancer stem cell traits
title_short	Molecular subclassification of gastrointestinal cancers based on cancer stem cell traits
title_full	Molecular subclassification of gastrointestinal cancers based on cancer stem cell traits
title_fullStr	Molecular subclassification of gastrointestinal cancers based on cancer stem cell traits
title_full_unstemmed	Molecular subclassification of gastrointestinal cancers based on cancer stem cell traits
title_sort	molecular subclassification of gastrointestinal cancers based on cancer stem cell traits
publisher	BMC
publishDate	2021
url	https://doaj.org/article/5cd65ad0364447f187fac285fb44c16d
work_keys_str_mv	AT meimeili molecularsubclassificationofgastrointestinalcancersbasedoncancerstemcelltraits AT junyuan molecularsubclassificationofgastrointestinalcancersbasedoncancerstemcelltraits AT xinyuanguan molecularsubclassificationofgastrointestinalcancersbasedoncancerstemcelltraits AT ningfangma molecularsubclassificationofgastrointestinalcancersbasedoncancerstemcelltraits AT mingliu molecularsubclassificationofgastrointestinalcancersbasedoncancerstemcelltraits
_version_	1718429405271818240

Molecular subclassification of gastrointestinal cancers based on cancer stem cell traits

Ejemplares similares