Fundus autofluorescence features in the inflammatory maculopathies

Cecilia S Lee,1 Aaron Y Lee,2 Farzin Forooghian,3 Chris S Bergstrom,1 Jiong Yan,1 Steven Yeh11Section of Vitreoretinal Disease and Surgery, Department of Ophthalmology, Emory Eye Center, Emory University, Atlanta, GA, USA; 2Department of Ophthalmology and Visual Sciences, Washington University in S...

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Autores principales:	Lee CS, Lee AY, Forooghian F, Bergstrom CS, Yan J, Yeh S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/5cdbd817e7424ee3aa6b0ebbaf590401
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spelling	oai:doaj.org-article:5cdbd817e7424ee3aa6b0ebbaf5904012021-12-02T00:34:54ZFundus autofluorescence features in the inflammatory maculopathies1177-5483https://doaj.org/article/5cdbd817e7424ee3aa6b0ebbaf5904012014-09-01T00:00:00Zhttp://www.dovepress.com/fundus-autofluorescence-features-in-the-inflammatory-maculopathies-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Cecilia S Lee,1 Aaron Y Lee,2 Farzin Forooghian,3 Chris S Bergstrom,1 Jiong Yan,1 Steven Yeh11Section of Vitreoretinal Disease and Surgery, Department of Ophthalmology, Emory Eye Center, Emory University, Atlanta, GA, USA; 2Department of Ophthalmology and Visual Sciences, Washington University in St Louis, St Louis, MO, USA; 3Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, CanadaPurpose: To describe the fundus autofluorescence (FAF) features of the inflammatory maculopathies and develop a quantification method for FAF analysis.Methods: This is a retrospective, consecutive case series of patients with inflammatory maculopathies from two tertiary centers. The clinical findings, demographics, and FAF imaging characteristics were reviewed. Foveal autofluorescence (AF) was analyzed. Median and standard deviation (SD) of foveal AF intensity were measured.Results: Thirty eyes of 15 patients were evaluated with both qualitative and quantitative FAF analysis. In acute macular neuroretinopathy, the active phase showed foveal hypoautofluorescence, which became hypoautofluorescent with resolution. In acute posterior multifocal placoid pigment epitheliopathy, multiple lesions with hypoautofluorescent centers with hyperautofluorescent borders were observed in active disease and became hypoautofluorescent with disease convalescence. In multifocal choroiditis and punctate inner choroiditis, the active hyperautofluorescent lesions progressed to inactive, hypoautofluorescent scars. Active serpiginous choroiditis showed hyperautofluorescent borders adjacent to a helicoid-shaped, hypoautofluorescent scar. Active unilateral acute idiopathic maculopathy (UAIM) showed a complex pattern of hypo- and hyperautoflourescence in the macula. The median foveal AF was the greatest in acute macular neuroretinopathy and UAIM among the maculopathies, while the greatest SD of foveal AF intensity was observed in UAIM.Conclusion: The active phase of the majority of inflammatory maculopathies was characterized by hyperautofluorescent lesions. Increased SD of foveal AF correlated with a mixture of hypo- and hyperautoflourescence. Median and SD may be useful metrics in foveal AF and quantifiable values that may be assessed over time as a disease process evolves. Improvements in quantification methods of FAF imaging may allow us to objectively evaluate posterior uveitis.Keywords: posterior uveitis, foveal autofluorescence, quantification, fundus autofluorescence imagingLee CSLee AYForooghian FBergstrom CSYan JYeh SDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 2001-2012 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Lee CS Lee AY Forooghian F Bergstrom CS Yan J Yeh S Fundus autofluorescence features in the inflammatory maculopathies
description	Cecilia S Lee,1 Aaron Y Lee,2 Farzin Forooghian,3 Chris S Bergstrom,1 Jiong Yan,1 Steven Yeh11Section of Vitreoretinal Disease and Surgery, Department of Ophthalmology, Emory Eye Center, Emory University, Atlanta, GA, USA; 2Department of Ophthalmology and Visual Sciences, Washington University in St Louis, St Louis, MO, USA; 3Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, CanadaPurpose: To describe the fundus autofluorescence (FAF) features of the inflammatory maculopathies and develop a quantification method for FAF analysis.Methods: This is a retrospective, consecutive case series of patients with inflammatory maculopathies from two tertiary centers. The clinical findings, demographics, and FAF imaging characteristics were reviewed. Foveal autofluorescence (AF) was analyzed. Median and standard deviation (SD) of foveal AF intensity were measured.Results: Thirty eyes of 15 patients were evaluated with both qualitative and quantitative FAF analysis. In acute macular neuroretinopathy, the active phase showed foveal hypoautofluorescence, which became hypoautofluorescent with resolution. In acute posterior multifocal placoid pigment epitheliopathy, multiple lesions with hypoautofluorescent centers with hyperautofluorescent borders were observed in active disease and became hypoautofluorescent with disease convalescence. In multifocal choroiditis and punctate inner choroiditis, the active hyperautofluorescent lesions progressed to inactive, hypoautofluorescent scars. Active serpiginous choroiditis showed hyperautofluorescent borders adjacent to a helicoid-shaped, hypoautofluorescent scar. Active unilateral acute idiopathic maculopathy (UAIM) showed a complex pattern of hypo- and hyperautoflourescence in the macula. The median foveal AF was the greatest in acute macular neuroretinopathy and UAIM among the maculopathies, while the greatest SD of foveal AF intensity was observed in UAIM.Conclusion: The active phase of the majority of inflammatory maculopathies was characterized by hyperautofluorescent lesions. Increased SD of foveal AF correlated with a mixture of hypo- and hyperautoflourescence. Median and SD may be useful metrics in foveal AF and quantifiable values that may be assessed over time as a disease process evolves. Improvements in quantification methods of FAF imaging may allow us to objectively evaluate posterior uveitis.Keywords: posterior uveitis, foveal autofluorescence, quantification, fundus autofluorescence imaging
format	article
author	Lee CS Lee AY Forooghian F Bergstrom CS Yan J Yeh S
author_facet	Lee CS Lee AY Forooghian F Bergstrom CS Yan J Yeh S
author_sort	Lee CS
title	Fundus autofluorescence features in the inflammatory maculopathies
title_short	Fundus autofluorescence features in the inflammatory maculopathies
title_full	Fundus autofluorescence features in the inflammatory maculopathies
title_fullStr	Fundus autofluorescence features in the inflammatory maculopathies
title_full_unstemmed	Fundus autofluorescence features in the inflammatory maculopathies
title_sort	fundus autofluorescence features in the inflammatory maculopathies
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/5cdbd817e7424ee3aa6b0ebbaf590401
work_keys_str_mv	AT leecs fundusautofluorescencefeaturesintheinflammatorymaculopathies AT leeay fundusautofluorescencefeaturesintheinflammatorymaculopathies AT forooghianf fundusautofluorescencefeaturesintheinflammatorymaculopathies AT bergstromcs fundusautofluorescencefeaturesintheinflammatorymaculopathies AT yanj fundusautofluorescencefeaturesintheinflammatorymaculopathies AT yehs fundusautofluorescencefeaturesintheinflammatorymaculopathies
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Fundus autofluorescence features in the inflammatory maculopathies

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