Lung volume, breathing pattern and ventilation inhomogeneity in preterm and term infants.

<h4>Background</h4>Morphological changes in preterm infants with bronchopulmonary dysplasia (BPD) have functional consequences on lung volume, ventilation inhomogeneity and respiratory mechanics. Although some studies have shown lower lung volumes and increased ventilation inhomogeneity...

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Autores principales:	Philipp Latzin, Stefan Roth, Cindy Thamrin, Gerard J Hutten, Isabelle Pramana, Claudia E Kuehni, Carmen Casaulta, Matthias Nelle, Thomas Riedel, Urs Frey
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5cdc970dd2c6471a9c1ba8f562acbc51
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spelling	oai:doaj.org-article:5cdc970dd2c6471a9c1ba8f562acbc512021-11-25T06:17:01ZLung volume, breathing pattern and ventilation inhomogeneity in preterm and term infants.1932-620310.1371/journal.pone.0004635https://doaj.org/article/5cdc970dd2c6471a9c1ba8f562acbc512009-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19247491/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Morphological changes in preterm infants with bronchopulmonary dysplasia (BPD) have functional consequences on lung volume, ventilation inhomogeneity and respiratory mechanics. Although some studies have shown lower lung volumes and increased ventilation inhomogeneity in BPD infants, conflicting results exist possibly due to differences in sedation and measurement techniques.<h4>Methodology/principal findings</h4>We studied 127 infants with BPD, 58 preterm infants without BPD and 239 healthy term-born infants, at a matched post-conceptional age of 44 weeks during quiet natural sleep according to ATS/ERS standards. Lung function parameters measured were functional residual capacity (FRC) and ventilation inhomogeneity by multiple breath washout as well as tidal breathing parameters. Preterm infants with BPD had only marginally lower FRC (21.4 mL/kg) than preterm infants without BPD (23.4 mL/kg) and term-born infants (22.6 mL/kg), though there was no trend with disease severity. They also showed higher respiratory rates and lower ratios of time to peak expiratory flow and expiratory time (t(PTEF)/t(E)) than healthy preterm and term controls. These changes were related to disease severity. No differences were found for ventilation inhomogeneity.<h4>Conclusions</h4>Our results suggest that preterm infants with BPD have a high capacity to maintain functional lung volume during natural sleep. The alterations in breathing pattern with disease severity may reflect presence of adaptive mechanisms to cope with the disease process.Philipp LatzinStefan RothCindy ThamrinGerard J HuttenIsabelle PramanaClaudia E KuehniCarmen CasaultaMatthias NelleThomas RiedelUrs FreyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 2, p e4635 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Philipp Latzin Stefan Roth Cindy Thamrin Gerard J Hutten Isabelle Pramana Claudia E Kuehni Carmen Casaulta Matthias Nelle Thomas Riedel Urs Frey Lung volume, breathing pattern and ventilation inhomogeneity in preterm and term infants.
description	<h4>Background</h4>Morphological changes in preterm infants with bronchopulmonary dysplasia (BPD) have functional consequences on lung volume, ventilation inhomogeneity and respiratory mechanics. Although some studies have shown lower lung volumes and increased ventilation inhomogeneity in BPD infants, conflicting results exist possibly due to differences in sedation and measurement techniques.<h4>Methodology/principal findings</h4>We studied 127 infants with BPD, 58 preterm infants without BPD and 239 healthy term-born infants, at a matched post-conceptional age of 44 weeks during quiet natural sleep according to ATS/ERS standards. Lung function parameters measured were functional residual capacity (FRC) and ventilation inhomogeneity by multiple breath washout as well as tidal breathing parameters. Preterm infants with BPD had only marginally lower FRC (21.4 mL/kg) than preterm infants without BPD (23.4 mL/kg) and term-born infants (22.6 mL/kg), though there was no trend with disease severity. They also showed higher respiratory rates and lower ratios of time to peak expiratory flow and expiratory time (t(PTEF)/t(E)) than healthy preterm and term controls. These changes were related to disease severity. No differences were found for ventilation inhomogeneity.<h4>Conclusions</h4>Our results suggest that preterm infants with BPD have a high capacity to maintain functional lung volume during natural sleep. The alterations in breathing pattern with disease severity may reflect presence of adaptive mechanisms to cope with the disease process.
format	article
author	Philipp Latzin Stefan Roth Cindy Thamrin Gerard J Hutten Isabelle Pramana Claudia E Kuehni Carmen Casaulta Matthias Nelle Thomas Riedel Urs Frey
author_facet	Philipp Latzin Stefan Roth Cindy Thamrin Gerard J Hutten Isabelle Pramana Claudia E Kuehni Carmen Casaulta Matthias Nelle Thomas Riedel Urs Frey
author_sort	Philipp Latzin
title	Lung volume, breathing pattern and ventilation inhomogeneity in preterm and term infants.
title_short	Lung volume, breathing pattern and ventilation inhomogeneity in preterm and term infants.
title_full	Lung volume, breathing pattern and ventilation inhomogeneity in preterm and term infants.
title_fullStr	Lung volume, breathing pattern and ventilation inhomogeneity in preterm and term infants.
title_full_unstemmed	Lung volume, breathing pattern and ventilation inhomogeneity in preterm and term infants.
title_sort	lung volume, breathing pattern and ventilation inhomogeneity in preterm and term infants.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/5cdc970dd2c6471a9c1ba8f562acbc51
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Lung volume, breathing pattern and ventilation inhomogeneity in preterm and term infants.

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