Antioxidant and hepatoprotective role of selenium against silver nanoparticles

Sabah Ansar,1 Saad M Alshehri,2 Manal Abudawood,1 Sherifa S Hamed,3,4 Tansir Ahamad2 1Clinical Laboratory Sciences, Applied Medical Science, King Saud University, Riyadh, Saudi Arabia; 2Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia; 3Zoology Department, Col...

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Autores principales:	Ansar S, Alshehri SM, Abudawood M, Hamed SS, Ahamad T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Silver nanoparticles selenium antioxidant enzymes hepatotoxicity oxidative stress Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5cddf7a24c8a4299a5d670e02e7c66e9
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spelling	oai:doaj.org-article:5cddf7a24c8a4299a5d670e02e7c66e92021-12-02T05:02:59ZAntioxidant and hepatoprotective role of selenium against silver nanoparticles1178-2013https://doaj.org/article/5cddf7a24c8a4299a5d670e02e7c66e92017-10-01T00:00:00Zhttps://www.dovepress.com/antioxidant-and-hepatoprotective-role-of-selenium-against-silver-nanop-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Sabah Ansar,1 Saad M Alshehri,2 Manal Abudawood,1 Sherifa S Hamed,3,4 Tansir Ahamad2 1Clinical Laboratory Sciences, Applied Medical Science, King Saud University, Riyadh, Saudi Arabia; 2Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia; 3Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia; 4Zoology Department, Faculty of Science, University of Alexandria, Moharram Bey, Alexandria, Egypt Abstract: Silver nanoparticles (AgNPs) have attracted the most interest in terms of their potential biomedical and industrial applications. However, these nanoparticles have shown their toxic behavior toward environment, living tissues, and organisms. Selenium (Se), an essential trace element, is necessary for various metabolic processes, including protection against oxidative stress and immune function. The present study was undertaken to evaluate the effect of Se against AgNP-induced hepatic oxidative stress. AgNPs were synthesized and then prepared nanoparticles were characterized using various analytical techniques such as UV-visible spectroscopy, X-ray diffraction, and transmission electron microscopy. Rats were administered AgNPs intraperitoneally (5 mg/kg/day) and Se (0.2 mg/kg) was given by gavage. AgNP administration induced hepatic damage as indicated by the serum marker enzymes with reduction in levels of glutathione, and decrease in activities of SOD, CAT, and GSH-peroxidase (P<0.05). Decrease in levels of total antioxidant capacity (TAC) and increase in level of C-reactive protein (CRP) was also observed in AgNP-treated group compared to control group. However, Se markedly attenuated AgNP-induced biochemical alterations, levels of TAC, CRP, and serum transaminases (AST, ALT) (P<0.05). Taken together, these findings suggest that administration of AgNPs produces hepatotoxicity in rats, whereas Se supplementation attenuates these effects. Keywords: silver nanoparticles, selenium, antioxidant enzymes, hepatotoxicity, oxidative stressAnsar SAlshehri SMAbudawood MHamed SSAhamad TDove Medical PressarticleSilver nanoparticlesseleniumantioxidant enzymeshepatotoxicityoxidative stressMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 7789-7797 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Silver nanoparticles selenium antioxidant enzymes hepatotoxicity oxidative stress Medicine (General) R5-920
spellingShingle	Silver nanoparticles selenium antioxidant enzymes hepatotoxicity oxidative stress Medicine (General) R5-920 Ansar S Alshehri SM Abudawood M Hamed SS Ahamad T Antioxidant and hepatoprotective role of selenium against silver nanoparticles
description	Sabah Ansar,1 Saad M Alshehri,2 Manal Abudawood,1 Sherifa S Hamed,3,4 Tansir Ahamad2 1Clinical Laboratory Sciences, Applied Medical Science, King Saud University, Riyadh, Saudi Arabia; 2Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia; 3Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia; 4Zoology Department, Faculty of Science, University of Alexandria, Moharram Bey, Alexandria, Egypt Abstract: Silver nanoparticles (AgNPs) have attracted the most interest in terms of their potential biomedical and industrial applications. However, these nanoparticles have shown their toxic behavior toward environment, living tissues, and organisms. Selenium (Se), an essential trace element, is necessary for various metabolic processes, including protection against oxidative stress and immune function. The present study was undertaken to evaluate the effect of Se against AgNP-induced hepatic oxidative stress. AgNPs were synthesized and then prepared nanoparticles were characterized using various analytical techniques such as UV-visible spectroscopy, X-ray diffraction, and transmission electron microscopy. Rats were administered AgNPs intraperitoneally (5 mg/kg/day) and Se (0.2 mg/kg) was given by gavage. AgNP administration induced hepatic damage as indicated by the serum marker enzymes with reduction in levels of glutathione, and decrease in activities of SOD, CAT, and GSH-peroxidase (P<0.05). Decrease in levels of total antioxidant capacity (TAC) and increase in level of C-reactive protein (CRP) was also observed in AgNP-treated group compared to control group. However, Se markedly attenuated AgNP-induced biochemical alterations, levels of TAC, CRP, and serum transaminases (AST, ALT) (P<0.05). Taken together, these findings suggest that administration of AgNPs produces hepatotoxicity in rats, whereas Se supplementation attenuates these effects. Keywords: silver nanoparticles, selenium, antioxidant enzymes, hepatotoxicity, oxidative stress
format	article
author	Ansar S Alshehri SM Abudawood M Hamed SS Ahamad T
author_facet	Ansar S Alshehri SM Abudawood M Hamed SS Ahamad T
author_sort	Ansar S
title	Antioxidant and hepatoprotective role of selenium against silver nanoparticles
title_short	Antioxidant and hepatoprotective role of selenium against silver nanoparticles
title_full	Antioxidant and hepatoprotective role of selenium against silver nanoparticles
title_fullStr	Antioxidant and hepatoprotective role of selenium against silver nanoparticles
title_full_unstemmed	Antioxidant and hepatoprotective role of selenium against silver nanoparticles
title_sort	antioxidant and hepatoprotective role of selenium against silver nanoparticles
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/5cddf7a24c8a4299a5d670e02e7c66e9
work_keys_str_mv	AT ansars antioxidantandhepatoprotectiveroleofseleniumagainstsilvernanoparticles AT alshehrism antioxidantandhepatoprotectiveroleofseleniumagainstsilvernanoparticles AT abudawoodm antioxidantandhepatoprotectiveroleofseleniumagainstsilvernanoparticles AT hamedss antioxidantandhepatoprotectiveroleofseleniumagainstsilvernanoparticles AT ahamadt antioxidantandhepatoprotectiveroleofseleniumagainstsilvernanoparticles
_version_	1718400711414251520

Antioxidant and hepatoprotective role of selenium against silver nanoparticles

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