The association between pulse wave velocity and cognitive function: the Sydney Memory and Ageing Study.

<h4>Objectives</h4>Pulse wave velocity (PWV) is a measure of arterial stiffness and its increase with ageing has been associated with damage to cerebral microvessels and cognitive impairment. This study examined the relationship between carotid-femoral PWV and specific domains of cogniti...

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Autores principales:	Joel Singer, Julian N Trollor, John Crawford, Michael F O'Rourke, Bernhard T Baune, Henry Brodaty, Katherine Samaras, Nicole A Kochan, Lesley Campbell, Perminder S Sachdev, Evelyn Smith
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5ce5f9a131754ef9ad0fc3045f0b4808
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spelling	oai:doaj.org-article:5ce5f9a131754ef9ad0fc3045f0b48082021-11-18T07:47:31ZThe association between pulse wave velocity and cognitive function: the Sydney Memory and Ageing Study.1932-620310.1371/journal.pone.0061855https://doaj.org/article/5ce5f9a131754ef9ad0fc3045f0b48082013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23637918/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>Pulse wave velocity (PWV) is a measure of arterial stiffness and its increase with ageing has been associated with damage to cerebral microvessels and cognitive impairment. This study examined the relationship between carotid-femoral PWV and specific domains of cognitive function in a non-demented elderly sample.<h4>Method</h4>Data were drawn from the Sydney Memory and Ageing Study, a cohort study of non-demented community-dwelling individuals aged 70-90 years, assessed in successive waves two years apart. In Wave 2, PWV and cognitive function were measured in 319 participants. Linear regression was used to analyse the cross-sectional relationship between arterial stiffness and cognitive function in the whole sample, and separately for men and women. Analysis of covariance was used to assess potential differences in cognition between subjects with PWV measurements in the top and bottom tertiles of the cohort. Covariates were age, education, body mass index, pulse rate, systolic blood pressure, cholesterol, depression, alcohol, smoking, hormone replacement therapy, apolipoprotein E ε4 genotype, use of anti-hypertensive medications, history of stroke, transient ischemic attack, myocardial infarction, angina, diabetes, and also sex for the whole sample analyses.<h4>Results</h4>There was no association between PWV and cognition after Bonferroni correction for multiple testing. When examining this association for males and females separately, an association was found in males, with higher PWV being associated with lower global cognition and memory, however, a significant difference between PWV and cognition between males and females was not found.<h4>Conclusion</h4>A higher level of PWV was not associated with lower cognitive function in the whole sample.Joel SingerJulian N TrollorJohn CrawfordMichael F O'RourkeBernhard T BauneHenry BrodatyKatherine SamarasNicole A KochanLesley CampbellPerminder S SachdevEvelyn SmithPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e61855 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joel Singer Julian N Trollor John Crawford Michael F O'Rourke Bernhard T Baune Henry Brodaty Katherine Samaras Nicole A Kochan Lesley Campbell Perminder S Sachdev Evelyn Smith The association between pulse wave velocity and cognitive function: the Sydney Memory and Ageing Study.
description	<h4>Objectives</h4>Pulse wave velocity (PWV) is a measure of arterial stiffness and its increase with ageing has been associated with damage to cerebral microvessels and cognitive impairment. This study examined the relationship between carotid-femoral PWV and specific domains of cognitive function in a non-demented elderly sample.<h4>Method</h4>Data were drawn from the Sydney Memory and Ageing Study, a cohort study of non-demented community-dwelling individuals aged 70-90 years, assessed in successive waves two years apart. In Wave 2, PWV and cognitive function were measured in 319 participants. Linear regression was used to analyse the cross-sectional relationship between arterial stiffness and cognitive function in the whole sample, and separately for men and women. Analysis of covariance was used to assess potential differences in cognition between subjects with PWV measurements in the top and bottom tertiles of the cohort. Covariates were age, education, body mass index, pulse rate, systolic blood pressure, cholesterol, depression, alcohol, smoking, hormone replacement therapy, apolipoprotein E ε4 genotype, use of anti-hypertensive medications, history of stroke, transient ischemic attack, myocardial infarction, angina, diabetes, and also sex for the whole sample analyses.<h4>Results</h4>There was no association between PWV and cognition after Bonferroni correction for multiple testing. When examining this association for males and females separately, an association was found in males, with higher PWV being associated with lower global cognition and memory, however, a significant difference between PWV and cognition between males and females was not found.<h4>Conclusion</h4>A higher level of PWV was not associated with lower cognitive function in the whole sample.
format	article
author	Joel Singer Julian N Trollor John Crawford Michael F O'Rourke Bernhard T Baune Henry Brodaty Katherine Samaras Nicole A Kochan Lesley Campbell Perminder S Sachdev Evelyn Smith
author_facet	Joel Singer Julian N Trollor John Crawford Michael F O'Rourke Bernhard T Baune Henry Brodaty Katherine Samaras Nicole A Kochan Lesley Campbell Perminder S Sachdev Evelyn Smith
author_sort	Joel Singer
title	The association between pulse wave velocity and cognitive function: the Sydney Memory and Ageing Study.
title_short	The association between pulse wave velocity and cognitive function: the Sydney Memory and Ageing Study.
title_full	The association between pulse wave velocity and cognitive function: the Sydney Memory and Ageing Study.
title_fullStr	The association between pulse wave velocity and cognitive function: the Sydney Memory and Ageing Study.
title_full_unstemmed	The association between pulse wave velocity and cognitive function: the Sydney Memory and Ageing Study.
title_sort	association between pulse wave velocity and cognitive function: the sydney memory and ageing study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/5ce5f9a131754ef9ad0fc3045f0b4808
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The association between pulse wave velocity and cognitive function: the Sydney Memory and Ageing Study.

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