Magnetic hydroxyapatite: a promising multifunctional platform for nanomedicine application

Sudip Mondal,1 Panchanathan Manivasagan,1 Subramaniyan Bharathiraja,1 Madhappan Santha Moorthy,1 Hye Hyun Kim,1 Hansu Seo,2 Kang Dae Lee,3 Junghwan Oh1,2 1Marine-Integrated Bionics Research Center, 2Department of Biomedical Engineering and Center for Marine-Integrated Biotechnology (BK21 Plus), Puk...

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Autores principales:	Mondal S, Manivasagan P, Bharathiraja S, Santha Moorthy M, Kim HH, Seo H, Lee KD, Oh J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Hydroxyapatite Iron oxide Hyperthermia Drug delivery Tissue engineering Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5ce638fe001f4d388b4b34ccdfa5b0ba
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spelling	oai:doaj.org-article:5ce638fe001f4d388b4b34ccdfa5b0ba2021-12-02T03:58:33ZMagnetic hydroxyapatite: a promising multifunctional platform for nanomedicine application1178-2013https://doaj.org/article/5ce638fe001f4d388b4b34ccdfa5b0ba2017-11-01T00:00:00Zhttps://www.dovepress.com/magnetic-hydroxyapatite-a-promising-multifunctional-platform-for-nanom-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Sudip Mondal,1 Panchanathan Manivasagan,1 Subramaniyan Bharathiraja,1 Madhappan Santha Moorthy,1 Hye Hyun Kim,1 Hansu Seo,2 Kang Dae Lee,3 Junghwan Oh1,2 1Marine-Integrated Bionics Research Center, 2Department of Biomedical Engineering and Center for Marine-Integrated Biotechnology (BK21 Plus), Pukyong National University, 3Department of Otolaryngology – Head and Neck Surgery, Kosin University College of Medicine, Busan, Republic of Korea Abstract: In this review, specific attention is paid to the development of nanostructured magnetic hydroxyapatite (MHAp) and its potential application in controlled drug/gene delivery, tissue engineering, magnetic hyperthermia treatment, and the development of contrast agents for magnetic resonance imaging. Both magnetite and hydroxyapatite materials have excellent prospects in nanomedicine with multifunctional therapeutic approaches. To date, many research articles have focused on biomedical applications of nanomaterials because of which it is very difficult to focus on any particular type of nanomaterial. This study is possibly the first effort to emphasize on the comprehensive assessment of MHAp nanostructures for biomedical applications supported with very recent experimental studies. From basic concepts to the real-life applications, the relevant characteristics of magnetic biomaterials are patented which are briefly discussed. The potential therapeutic and diagnostic ability of MHAp-nanostructured materials make them an ideal platform for future nanomedicine. We hope that this advanced review will provide a better understanding of MHAp and its important features to utilize it as a promising material for multifunctional biomedical applications. Keywords: hydroxyapatite, iron oxide, hyperthermia, drug delivery, tissue engineeringMondal SManivasagan PBharathiraja SSantha Moorthy MKim HHSeo HLee KDOh JDove Medical PressarticleHydroxyapatiteIron oxideHyperthermiaDrug deliveryTissue engineeringMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 8389-8410 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hydroxyapatite Iron oxide Hyperthermia Drug delivery Tissue engineering Medicine (General) R5-920
spellingShingle	Hydroxyapatite Iron oxide Hyperthermia Drug delivery Tissue engineering Medicine (General) R5-920 Mondal S Manivasagan P Bharathiraja S Santha Moorthy M Kim HH Seo H Lee KD Oh J Magnetic hydroxyapatite: a promising multifunctional platform for nanomedicine application
description	Sudip Mondal,1 Panchanathan Manivasagan,1 Subramaniyan Bharathiraja,1 Madhappan Santha Moorthy,1 Hye Hyun Kim,1 Hansu Seo,2 Kang Dae Lee,3 Junghwan Oh1,2 1Marine-Integrated Bionics Research Center, 2Department of Biomedical Engineering and Center for Marine-Integrated Biotechnology (BK21 Plus), Pukyong National University, 3Department of Otolaryngology – Head and Neck Surgery, Kosin University College of Medicine, Busan, Republic of Korea Abstract: In this review, specific attention is paid to the development of nanostructured magnetic hydroxyapatite (MHAp) and its potential application in controlled drug/gene delivery, tissue engineering, magnetic hyperthermia treatment, and the development of contrast agents for magnetic resonance imaging. Both magnetite and hydroxyapatite materials have excellent prospects in nanomedicine with multifunctional therapeutic approaches. To date, many research articles have focused on biomedical applications of nanomaterials because of which it is very difficult to focus on any particular type of nanomaterial. This study is possibly the first effort to emphasize on the comprehensive assessment of MHAp nanostructures for biomedical applications supported with very recent experimental studies. From basic concepts to the real-life applications, the relevant characteristics of magnetic biomaterials are patented which are briefly discussed. The potential therapeutic and diagnostic ability of MHAp-nanostructured materials make them an ideal platform for future nanomedicine. We hope that this advanced review will provide a better understanding of MHAp and its important features to utilize it as a promising material for multifunctional biomedical applications. Keywords: hydroxyapatite, iron oxide, hyperthermia, drug delivery, tissue engineering
format	article
author	Mondal S Manivasagan P Bharathiraja S Santha Moorthy M Kim HH Seo H Lee KD Oh J
author_facet	Mondal S Manivasagan P Bharathiraja S Santha Moorthy M Kim HH Seo H Lee KD Oh J
author_sort	Mondal S
title	Magnetic hydroxyapatite: a promising multifunctional platform for nanomedicine application
title_short	Magnetic hydroxyapatite: a promising multifunctional platform for nanomedicine application
title_full	Magnetic hydroxyapatite: a promising multifunctional platform for nanomedicine application
title_fullStr	Magnetic hydroxyapatite: a promising multifunctional platform for nanomedicine application
title_full_unstemmed	Magnetic hydroxyapatite: a promising multifunctional platform for nanomedicine application
title_sort	magnetic hydroxyapatite: a promising multifunctional platform for nanomedicine application
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/5ce638fe001f4d388b4b34ccdfa5b0ba
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Magnetic hydroxyapatite: a promising multifunctional platform for nanomedicine application

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