Influence of Preventive Tooth Extractions on Quality of Life in Patients with Antiresorptive Intake—A Prospective Longitudinal Study

Background: To find out whether preventive tooth extractions in patients on antiresorptive therapy have a direct impact on the patients’ overall quality of life (QoL); Methods: QoL using the five-level version of the EuroQol Group’s EQ-5D instrument (EQ-5D-5L) was longitudinally assessed in N = 114...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Thomas Rückschloß, Julius Moratin, Sven Zittel, Maximilian Pilz, Christoph Roser, Michael Engel, Christian Freudlsperger, Jürgen Hoffmann, Oliver Ristow
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	quality of life tooth extraction bisphosphonates denosumab EQ-5D Medicine R
Acceso en línea:	https://doaj.org/article/5ce9ef8534ad4fe0b7f7bc2a4e2541cb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5ce9ef8534ad4fe0b7f7bc2a4e2541cb
record_format	dspace
spelling	oai:doaj.org-article:5ce9ef8534ad4fe0b7f7bc2a4e2541cb2021-11-11T16:44:59ZInfluence of Preventive Tooth Extractions on Quality of Life in Patients with Antiresorptive Intake—A Prospective Longitudinal Study10.3390/ijerph1821116501660-46011661-7827https://doaj.org/article/5ce9ef8534ad4fe0b7f7bc2a4e2541cb2021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11650https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Background: To find out whether preventive tooth extractions in patients on antiresorptive therapy have a direct impact on the patients’ overall quality of life (QoL); Methods: QoL using the five-level version of the EuroQol Group’s EQ-5D instrument (EQ-5D-5L) was longitudinally assessed in N = 114 prospectively enrolled patients with indication of preventive tooth extraction over a period of 12 months. Patients were stratified as high-risk (malignant disease with bone metastasis or multiple myeloma, with monthly high-dose antiresorptive therapy delivered intravenously [bisphosphonate] or subcutaneously [denosumab]) and low-risk/osteoporosis patients (weekly low-dose antiresorptive therapy administered orally [bisphosphonate] or half-yearly subcutaneously [denosumab]). The measurement time points were 4 weeks preoperatively (T0), 2 months (T1) and 1 year postoperatively (T2), respectively. Results: EQ-5D-5L index scores fell in a range from −0.21 to 1.00 in the low-risk group to 0.15 to 1.00 in the high-risk group. The <i>t</i>-test comparing the baseline index scores of both groups showed EQ-5D-5L index score in the low-risk group (0.708 ± 0.292) to be significantly smaller (<i>p</i> = 0.037) than in the high-risk group (0.807 ± 0.19). ANCOVA showed no significant differences in EQ-5D-5L index scores between the groups at T1 and T2. Conclusions: Preventive tooth extractions in patients undergoing antiresorptive treatment have no negative effect on QoL. Therefore, if indicated, preventive tooth extraction should not be omitted. Patient-oriented outcome measures are important to obtain a good risk–benefit balance for patient-specific treatment.Thomas RückschloßJulius MoratinSven ZittelMaximilian PilzChristoph RoserMichael EngelChristian FreudlspergerJürgen HoffmannOliver RistowMDPI AGarticlequality of lifetooth extractionbisphosphonatesdenosumabEQ-5DMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11650, p 11650 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	quality of life tooth extraction bisphosphonates denosumab EQ-5D Medicine R
spellingShingle	quality of life tooth extraction bisphosphonates denosumab EQ-5D Medicine R Thomas Rückschloß Julius Moratin Sven Zittel Maximilian Pilz Christoph Roser Michael Engel Christian Freudlsperger Jürgen Hoffmann Oliver Ristow Influence of Preventive Tooth Extractions on Quality of Life in Patients with Antiresorptive Intake—A Prospective Longitudinal Study
description	Background: To find out whether preventive tooth extractions in patients on antiresorptive therapy have a direct impact on the patients’ overall quality of life (QoL); Methods: QoL using the five-level version of the EuroQol Group’s EQ-5D instrument (EQ-5D-5L) was longitudinally assessed in N = 114 prospectively enrolled patients with indication of preventive tooth extraction over a period of 12 months. Patients were stratified as high-risk (malignant disease with bone metastasis or multiple myeloma, with monthly high-dose antiresorptive therapy delivered intravenously [bisphosphonate] or subcutaneously [denosumab]) and low-risk/osteoporosis patients (weekly low-dose antiresorptive therapy administered orally [bisphosphonate] or half-yearly subcutaneously [denosumab]). The measurement time points were 4 weeks preoperatively (T0), 2 months (T1) and 1 year postoperatively (T2), respectively. Results: EQ-5D-5L index scores fell in a range from −0.21 to 1.00 in the low-risk group to 0.15 to 1.00 in the high-risk group. The <i>t</i>-test comparing the baseline index scores of both groups showed EQ-5D-5L index score in the low-risk group (0.708 ± 0.292) to be significantly smaller (<i>p</i> = 0.037) than in the high-risk group (0.807 ± 0.19). ANCOVA showed no significant differences in EQ-5D-5L index scores between the groups at T1 and T2. Conclusions: Preventive tooth extractions in patients undergoing antiresorptive treatment have no negative effect on QoL. Therefore, if indicated, preventive tooth extraction should not be omitted. Patient-oriented outcome measures are important to obtain a good risk–benefit balance for patient-specific treatment.
format	article
author	Thomas Rückschloß Julius Moratin Sven Zittel Maximilian Pilz Christoph Roser Michael Engel Christian Freudlsperger Jürgen Hoffmann Oliver Ristow
author_facet	Thomas Rückschloß Julius Moratin Sven Zittel Maximilian Pilz Christoph Roser Michael Engel Christian Freudlsperger Jürgen Hoffmann Oliver Ristow
author_sort	Thomas Rückschloß
title	Influence of Preventive Tooth Extractions on Quality of Life in Patients with Antiresorptive Intake—A Prospective Longitudinal Study
title_short	Influence of Preventive Tooth Extractions on Quality of Life in Patients with Antiresorptive Intake—A Prospective Longitudinal Study
title_full	Influence of Preventive Tooth Extractions on Quality of Life in Patients with Antiresorptive Intake—A Prospective Longitudinal Study
title_fullStr	Influence of Preventive Tooth Extractions on Quality of Life in Patients with Antiresorptive Intake—A Prospective Longitudinal Study
title_full_unstemmed	Influence of Preventive Tooth Extractions on Quality of Life in Patients with Antiresorptive Intake—A Prospective Longitudinal Study
title_sort	influence of preventive tooth extractions on quality of life in patients with antiresorptive intake—a prospective longitudinal study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5ce9ef8534ad4fe0b7f7bc2a4e2541cb
work_keys_str_mv	AT thomasruckschloß influenceofpreventivetoothextractionsonqualityoflifeinpatientswithantiresorptiveintakeaprospectivelongitudinalstudy AT juliusmoratin influenceofpreventivetoothextractionsonqualityoflifeinpatientswithantiresorptiveintakeaprospectivelongitudinalstudy AT svenzittel influenceofpreventivetoothextractionsonqualityoflifeinpatientswithantiresorptiveintakeaprospectivelongitudinalstudy AT maximilianpilz influenceofpreventivetoothextractionsonqualityoflifeinpatientswithantiresorptiveintakeaprospectivelongitudinalstudy AT christophroser influenceofpreventivetoothextractionsonqualityoflifeinpatientswithantiresorptiveintakeaprospectivelongitudinalstudy AT michaelengel influenceofpreventivetoothextractionsonqualityoflifeinpatientswithantiresorptiveintakeaprospectivelongitudinalstudy AT christianfreudlsperger influenceofpreventivetoothextractionsonqualityoflifeinpatientswithantiresorptiveintakeaprospectivelongitudinalstudy AT jurgenhoffmann influenceofpreventivetoothextractionsonqualityoflifeinpatientswithantiresorptiveintakeaprospectivelongitudinalstudy AT oliverristow influenceofpreventivetoothextractionsonqualityoflifeinpatientswithantiresorptiveintakeaprospectivelongitudinalstudy
_version_	1718432240537436160

Influence of Preventive Tooth Extractions on Quality of Life in Patients with Antiresorptive Intake—A Prospective Longitudinal Study

Ejemplares similares