Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma

Oral squamous cell carcinoma (OSCC) is the most prevalent oral malignant tumor worldwide. An early diagnosis can have a major positive impact on its prognosis. Human saliva contains cytokines, DNA and RNA molecules, circulating cells, and derivatives of tissues and extracellular vesicles, among othe...

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Autores principales:	Francisco Javier Manzano-Moreno, Victor J. Costela-Ruiz, Enrique García-Recio, Maria Victoria Olmedo-Gaya, Concepción Ruiz, Candelaria Reyes-Botella
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	salivary biomarker microRNA cytokines oral pathology diagnosis oral cancer Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/5ceabb4da63340ffb19057057c765fa4
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id	oai:doaj.org-article:5ceabb4da63340ffb19057057c765fa4
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spelling	oai:doaj.org-article:5ceabb4da63340ffb19057057c765fa42021-11-25T17:54:24ZRole of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma10.3390/ijms2222122151422-00671661-6596https://doaj.org/article/5ceabb4da63340ffb19057057c765fa42021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12215https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Oral squamous cell carcinoma (OSCC) is the most prevalent oral malignant tumor worldwide. An early diagnosis can have a major positive impact on its prognosis. Human saliva contains cytokines, DNA and RNA molecules, circulating cells, and derivatives of tissues and extracellular vesicles, among other factors that can serve as biomarkers. Hence, the analysis of saliva may provide useful information for the early diagnosis of OSCC for its prognosis. The objective of this review was to determine the potential usefulness of salivary biomarkers (cytokines and microRNA) to diagnose OSCC and improve its prognosis. A combination of salivary miRNA and proteomic data could allow a definitive and early diagnosis to be obtained. However, there remains a need to optimize and standardize the protocols used to quantify miRNAs.Francisco Javier Manzano-MorenoVictor J. Costela-RuizEnrique García-RecioMaria Victoria Olmedo-GayaConcepción RuizCandelaria Reyes-BotellaMDPI AGarticlesalivary biomarkermicroRNAcytokinesoral pathologydiagnosisoral cancerBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12215, p 12215 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	salivary biomarker microRNA cytokines oral pathology diagnosis oral cancer Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	salivary biomarker microRNA cytokines oral pathology diagnosis oral cancer Biology (General) QH301-705.5 Chemistry QD1-999 Francisco Javier Manzano-Moreno Victor J. Costela-Ruiz Enrique García-Recio Maria Victoria Olmedo-Gaya Concepción Ruiz Candelaria Reyes-Botella Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma
description	Oral squamous cell carcinoma (OSCC) is the most prevalent oral malignant tumor worldwide. An early diagnosis can have a major positive impact on its prognosis. Human saliva contains cytokines, DNA and RNA molecules, circulating cells, and derivatives of tissues and extracellular vesicles, among other factors that can serve as biomarkers. Hence, the analysis of saliva may provide useful information for the early diagnosis of OSCC for its prognosis. The objective of this review was to determine the potential usefulness of salivary biomarkers (cytokines and microRNA) to diagnose OSCC and improve its prognosis. A combination of salivary miRNA and proteomic data could allow a definitive and early diagnosis to be obtained. However, there remains a need to optimize and standardize the protocols used to quantify miRNAs.
format	article
author	Francisco Javier Manzano-Moreno Victor J. Costela-Ruiz Enrique García-Recio Maria Victoria Olmedo-Gaya Concepción Ruiz Candelaria Reyes-Botella
author_facet	Francisco Javier Manzano-Moreno Victor J. Costela-Ruiz Enrique García-Recio Maria Victoria Olmedo-Gaya Concepción Ruiz Candelaria Reyes-Botella
author_sort	Francisco Javier Manzano-Moreno
title	Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma
title_short	Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma
title_full	Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma
title_fullStr	Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma
title_full_unstemmed	Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma
title_sort	role of salivary microrna and cytokines in the diagnosis and prognosis of oral squamous cell carcinoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5ceabb4da63340ffb19057057c765fa4
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Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma

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