An Established Th2-Oriented Response to an Alum-Adjuvanted SARS-CoV-2 Subunit Vaccine Is Not Reversible by Sequential Immunization with Nucleic Acid-Adjuvanted Th1-Oriented Subunit Vaccines

An Established Th2-Oriented Response to an Alum-Adjuvanted SARS-CoV-2 Subunit Vaccine Is Not Reversible by Sequential Immunization with Nucleic Acid-Adjuvanted Th1-Oriented Subunit Vaccines

A recently reported parallel preclinical study between a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine and an inactivated SARS-CoV-2 vaccine adjuvanted with alum showed pulmonary immunopathology typical of eosinophil accumulation in a mouse pneumonia model for the latter,...

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Bibliographic Details
Main Authors: Han Cao, Shengran Yang, Yunfei Wang, Ning Luan, Xingxiao Yin, Kangyang Lin, Cunbao Liu
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
SARS-CoV-2 subunit vaccine
Th1/Th2 orientation
alum adjuvant
nucleic acid adjuvant
prime-boost
homogenous boost immunization
Medicine
R
Online Access:https://doaj.org/article/5ceb0ef61a884eefadfdc00ad3a3b079
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