Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane

Rif1 is involved in different processes such as telomere homeostasis, DNA replication timing, and DNA double strand break (DSB) repair pathway choice. Here, the authors reveal that Rif1 S-acylation facilitates the accumulation of Rif1 at DSBs, attenuation of DNA end-resection, and DSB repair by non-...

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Auteurs principaux:	Gabriele A. Fontana, Daniel Hess, Julia K. Reinert, Stefano Mattarocci, Benoît Falquet, Dominique Klein, David Shore, Nicolas H. Thomä, Ulrich Rass
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/5cf20ca662034689ad49ccb51a846d04
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spelling	oai:doaj.org-article:5cf20ca662034689ad49ccb51a846d042021-12-02T16:57:19ZRif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane10.1038/s41467-019-10349-z2041-1723https://doaj.org/article/5cf20ca662034689ad49ccb51a846d042019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10349-zhttps://doaj.org/toc/2041-1723Rif1 is involved in different processes such as telomere homeostasis, DNA replication timing, and DNA double strand break (DSB) repair pathway choice. Here, the authors reveal that Rif1 S-acylation facilitates the accumulation of Rif1 at DSBs, attenuation of DNA end-resection, and DSB repair by non-homologous end-joining.Gabriele A. FontanaDaniel HessJulia K. ReinertStefano MattarocciBenoît FalquetDominique KleinDavid ShoreNicolas H. ThomäUlrich RassNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gabriele A. Fontana Daniel Hess Julia K. Reinert Stefano Mattarocci Benoît Falquet Dominique Klein David Shore Nicolas H. Thomä Ulrich Rass Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane
description	Rif1 is involved in different processes such as telomere homeostasis, DNA replication timing, and DNA double strand break (DSB) repair pathway choice. Here, the authors reveal that Rif1 S-acylation facilitates the accumulation of Rif1 at DSBs, attenuation of DNA end-resection, and DSB repair by non-homologous end-joining.
format	article
author	Gabriele A. Fontana Daniel Hess Julia K. Reinert Stefano Mattarocci Benoît Falquet Dominique Klein David Shore Nicolas H. Thomä Ulrich Rass
author_facet	Gabriele A. Fontana Daniel Hess Julia K. Reinert Stefano Mattarocci Benoît Falquet Dominique Klein David Shore Nicolas H. Thomä Ulrich Rass
author_sort	Gabriele A. Fontana
title	Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane
title_short	Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane
title_full	Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane
title_fullStr	Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane
title_full_unstemmed	Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane
title_sort	rif1 s-acylation mediates dna double-strand break repair at the inner nuclear membrane
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5cf20ca662034689ad49ccb51a846d04
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Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane

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