Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane

Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane

Rif1 is involved in different processes such as telomere homeostasis, DNA replication timing, and DNA double strand break (DSB) repair pathway choice. Here, the authors reveal that Rif1 S-acylation facilitates the accumulation of Rif1 at DSBs, attenuation of DNA end-resection, and DSB repair by non-...

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Autores principales: Gabriele A. Fontana, Daniel Hess, Julia K. Reinert, Stefano Mattarocci, Benoît Falquet, Dominique Klein, David Shore, Nicolas H. Thomä, Ulrich Rass
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/5cf20ca662034689ad49ccb51a846d04
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