Post-treatment with Ma-Huang-Tang ameliorates cold-warm-cycles induced rat lung injury

Abstract Frequent and drastic ambient temperature variation may cause respiratory diseases such as common cold and pneumonia, the mechanism for which is not fully understood, however, due to lack of appropriate animal models. Ma-Huang-Tang (MHT) is widely used in China for treatment of respiratory d...

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Autores principales:	Meng-Meng Xiao, Chun-Shui Pan, Yu-Ying Liu, Li-Qian Ma, Li Yan, Jing-Yu Fan, Chuan-She Wang, Rong Huang, Jing-Yan Han
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5cf3920a5c91457b997b113a9125ff25
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spelling	oai:doaj.org-article:5cf3920a5c91457b997b113a9125ff252021-12-02T16:07:48ZPost-treatment with Ma-Huang-Tang ameliorates cold-warm-cycles induced rat lung injury10.1038/s41598-017-00459-32045-2322https://doaj.org/article/5cf3920a5c91457b997b113a9125ff252017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00459-3https://doaj.org/toc/2045-2322Abstract Frequent and drastic ambient temperature variation may cause respiratory diseases such as common cold and pneumonia, the mechanism for which is not fully understood, however, due to lack of appropriate animal models. Ma-Huang-Tang (MHT) is widely used in China for treatment of respiratory diseases. The present study aimed to investigate the effect of MHT on temperature alternation induced rat lung injury and explore underlying mechanisms. Male Sprague-Dawley rats were exposed to a cold environment for 1 h and then shifted to a warm environment for 30 min. This cold and warm alteration cycled 4 times. Rats were administrated with MHT (1.87 g/kg) by gavage 6 h after cold-warm-cycles. Cold-warm-cycles induced pulmonary microcirculatory disorders, lung edema and injury, decrease in the expression of tight junction proteins, increase in VE-cadherin activation, increase in the expression and activation of Caveolin-1, Src and NF-κB, and NADPH oxidase subunits p47phox, p40phox and p67phox membrane translocation and inflammatory cytokines production. All alterations were significantly ameliorated by post-treatment with MHT. This study showed that rats subjected to cold-warm-cycles may be used as an animal model to investigate ambient temperature variation-induced lung injury, and suggested MHT as a potential strategy to combat lung injury induced by temperature variation.Meng-Meng XiaoChun-Shui PanYu-Ying LiuLi-Qian MaLi YanJing-Yu FanChuan-She WangRong HuangJing-Yan HanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Meng-Meng Xiao Chun-Shui Pan Yu-Ying Liu Li-Qian Ma Li Yan Jing-Yu Fan Chuan-She Wang Rong Huang Jing-Yan Han Post-treatment with Ma-Huang-Tang ameliorates cold-warm-cycles induced rat lung injury
description	Abstract Frequent and drastic ambient temperature variation may cause respiratory diseases such as common cold and pneumonia, the mechanism for which is not fully understood, however, due to lack of appropriate animal models. Ma-Huang-Tang (MHT) is widely used in China for treatment of respiratory diseases. The present study aimed to investigate the effect of MHT on temperature alternation induced rat lung injury and explore underlying mechanisms. Male Sprague-Dawley rats were exposed to a cold environment for 1 h and then shifted to a warm environment for 30 min. This cold and warm alteration cycled 4 times. Rats were administrated with MHT (1.87 g/kg) by gavage 6 h after cold-warm-cycles. Cold-warm-cycles induced pulmonary microcirculatory disorders, lung edema and injury, decrease in the expression of tight junction proteins, increase in VE-cadherin activation, increase in the expression and activation of Caveolin-1, Src and NF-κB, and NADPH oxidase subunits p47phox, p40phox and p67phox membrane translocation and inflammatory cytokines production. All alterations were significantly ameliorated by post-treatment with MHT. This study showed that rats subjected to cold-warm-cycles may be used as an animal model to investigate ambient temperature variation-induced lung injury, and suggested MHT as a potential strategy to combat lung injury induced by temperature variation.
format	article
author	Meng-Meng Xiao Chun-Shui Pan Yu-Ying Liu Li-Qian Ma Li Yan Jing-Yu Fan Chuan-She Wang Rong Huang Jing-Yan Han
author_facet	Meng-Meng Xiao Chun-Shui Pan Yu-Ying Liu Li-Qian Ma Li Yan Jing-Yu Fan Chuan-She Wang Rong Huang Jing-Yan Han
author_sort	Meng-Meng Xiao
title	Post-treatment with Ma-Huang-Tang ameliorates cold-warm-cycles induced rat lung injury
title_short	Post-treatment with Ma-Huang-Tang ameliorates cold-warm-cycles induced rat lung injury
title_full	Post-treatment with Ma-Huang-Tang ameliorates cold-warm-cycles induced rat lung injury
title_fullStr	Post-treatment with Ma-Huang-Tang ameliorates cold-warm-cycles induced rat lung injury
title_full_unstemmed	Post-treatment with Ma-Huang-Tang ameliorates cold-warm-cycles induced rat lung injury
title_sort	post-treatment with ma-huang-tang ameliorates cold-warm-cycles induced rat lung injury
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5cf3920a5c91457b997b113a9125ff25
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Post-treatment with Ma-Huang-Tang ameliorates cold-warm-cycles induced rat lung injury

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