Mitochondrial Dysfunction in Cancer Cachexia: Impact on Muscle Health and Regeneration

Cancer cachexia is a frequently neglected debilitating syndrome that, beyond representing a primary cause of death and cancer therapy failure, negatively impacts on patients’ quality of life. Given the complexity of its multisystemic pathogenesis, affecting several organs beyond the skeletal muscle,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Marc Beltrà, Fabrizio Pin, Riccardo Ballarò, Paola Costelli, Fabio Penna
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer cachexia muscle wasting mitochondria regeneration myogenesis PGC-1α Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5cfc9d5895df420a8f92fa117f58ac2b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5cfc9d5895df420a8f92fa117f58ac2b
record_format	dspace
spelling	oai:doaj.org-article:5cfc9d5895df420a8f92fa117f58ac2b2021-11-25T17:12:00ZMitochondrial Dysfunction in Cancer Cachexia: Impact on Muscle Health and Regeneration10.3390/cells101131502073-4409https://doaj.org/article/5cfc9d5895df420a8f92fa117f58ac2b2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3150https://doaj.org/toc/2073-4409Cancer cachexia is a frequently neglected debilitating syndrome that, beyond representing a primary cause of death and cancer therapy failure, negatively impacts on patients’ quality of life. Given the complexity of its multisystemic pathogenesis, affecting several organs beyond the skeletal muscle, defining an effective therapeutic approach has failed so far. Revamped attention of the scientific community working on cancer cachexia has focused on mitochondrial alterations occurring in the skeletal muscle as potential triggers of the complex metabolic derangements, eventually leading to hypercatabolism and tissue wasting. Mitochondrial dysfunction may be simplistically viewed as a cause of energy failure, thus inducing protein catabolism as a compensatory mechanism; however, other peculiar cachexia features may depend on mitochondria. On the one side, chemotherapy also impacts on muscle mitochondrial function while, on the other side, muscle-impaired regeneration may result from insufficient energy production from damaged mitochondria. Boosting mitochondrial function could thus improve the energetic status and chemotherapy tolerance, and relieve the myogenic process in cancer cachexia. In the present work, a focused review of the available literature on mitochondrial dysfunction in cancer cachexia is presented along with preliminary data dissecting the potential role of stimulating mitochondrial biogenesis via PGC-1α overexpression in distinct aspects of cancer-induced muscle wasting.Marc BeltràFabrizio PinRiccardo BallaròPaola CostelliFabio PennaMDPI AGarticlecancer cachexiamuscle wastingmitochondriaregenerationmyogenesisPGC-1αBiology (General)QH301-705.5ENCells, Vol 10, Iss 3150, p 3150 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer cachexia muscle wasting mitochondria regeneration myogenesis PGC-1α Biology (General) QH301-705.5
spellingShingle	cancer cachexia muscle wasting mitochondria regeneration myogenesis PGC-1α Biology (General) QH301-705.5 Marc Beltrà Fabrizio Pin Riccardo Ballarò Paola Costelli Fabio Penna Mitochondrial Dysfunction in Cancer Cachexia: Impact on Muscle Health and Regeneration
description	Cancer cachexia is a frequently neglected debilitating syndrome that, beyond representing a primary cause of death and cancer therapy failure, negatively impacts on patients’ quality of life. Given the complexity of its multisystemic pathogenesis, affecting several organs beyond the skeletal muscle, defining an effective therapeutic approach has failed so far. Revamped attention of the scientific community working on cancer cachexia has focused on mitochondrial alterations occurring in the skeletal muscle as potential triggers of the complex metabolic derangements, eventually leading to hypercatabolism and tissue wasting. Mitochondrial dysfunction may be simplistically viewed as a cause of energy failure, thus inducing protein catabolism as a compensatory mechanism; however, other peculiar cachexia features may depend on mitochondria. On the one side, chemotherapy also impacts on muscle mitochondrial function while, on the other side, muscle-impaired regeneration may result from insufficient energy production from damaged mitochondria. Boosting mitochondrial function could thus improve the energetic status and chemotherapy tolerance, and relieve the myogenic process in cancer cachexia. In the present work, a focused review of the available literature on mitochondrial dysfunction in cancer cachexia is presented along with preliminary data dissecting the potential role of stimulating mitochondrial biogenesis via PGC-1α overexpression in distinct aspects of cancer-induced muscle wasting.
format	article
author	Marc Beltrà Fabrizio Pin Riccardo Ballarò Paola Costelli Fabio Penna
author_facet	Marc Beltrà Fabrizio Pin Riccardo Ballarò Paola Costelli Fabio Penna
author_sort	Marc Beltrà
title	Mitochondrial Dysfunction in Cancer Cachexia: Impact on Muscle Health and Regeneration
title_short	Mitochondrial Dysfunction in Cancer Cachexia: Impact on Muscle Health and Regeneration
title_full	Mitochondrial Dysfunction in Cancer Cachexia: Impact on Muscle Health and Regeneration
title_fullStr	Mitochondrial Dysfunction in Cancer Cachexia: Impact on Muscle Health and Regeneration
title_full_unstemmed	Mitochondrial Dysfunction in Cancer Cachexia: Impact on Muscle Health and Regeneration
title_sort	mitochondrial dysfunction in cancer cachexia: impact on muscle health and regeneration
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5cfc9d5895df420a8f92fa117f58ac2b
work_keys_str_mv	AT marcbeltra mitochondrialdysfunctionincancercachexiaimpactonmusclehealthandregeneration AT fabriziopin mitochondrialdysfunctionincancercachexiaimpactonmusclehealthandregeneration AT riccardoballaro mitochondrialdysfunctionincancercachexiaimpactonmusclehealthandregeneration AT paolacostelli mitochondrialdysfunctionincancercachexiaimpactonmusclehealthandregeneration AT fabiopenna mitochondrialdysfunctionincancercachexiaimpactonmusclehealthandregeneration
_version_	1718412652366004224

Mitochondrial Dysfunction in Cancer Cachexia: Impact on Muscle Health and Regeneration

Ejemplares similares