Solubility of Cinnarizine in (Transcutol + Water) Mixtures: Determination, Hansen Solubility Parameters, Correlation, and Thermodynamics

Between 293.2 and 313.2 K and at 0.1 MPa, the solubility of the weak base, cinnarizine (CNZ) (3), in various {Transcutol-P (TP) (1) + water (2)} combinations is reported. The Hansen solubility parameters (HSP) of CNZ and various {(TP) (1) + water (2)} mixtures free of CNZ were also predicted using H...

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Autores principales:	Faiyaz Shakeel, Mohsin Kazi, Fars K. Alanazi, Prawez Alam
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cinnarizine {Transcutol-P (1) + water (2)} mixtures correlation solubility thermodynamics Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/5cfca3810e054abb969e501f86c7fffb
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spelling	oai:doaj.org-article:5cfca3810e054abb969e501f86c7fffb2021-11-25T18:29:28ZSolubility of Cinnarizine in (Transcutol + Water) Mixtures: Determination, Hansen Solubility Parameters, Correlation, and Thermodynamics10.3390/molecules262270521420-3049https://doaj.org/article/5cfca3810e054abb969e501f86c7fffb2021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/7052https://doaj.org/toc/1420-3049Between 293.2 and 313.2 K and at 0.1 MPa, the solubility of the weak base, cinnarizine (CNZ) (3), in various {Transcutol-P (TP) (1) + water (2)} combinations is reported. The Hansen solubility parameters (HSP) of CNZ and various {(TP) (1) + water (2)} mixtures free of CNZ were also predicted using HSPiP software. Five distinct cosolvency-based mathematical models were used to link the experimentally determined solubility data of CNZ. The solubility of CNZ in mole fraction was increased with elevated temperature and TP mass fraction in {(TP) (1) + water (2)} combinations. The maximum solubility of CNZ in mole fraction was achieved in neat TP (5.83 × 10<sup>−2</sup> at 313.2 K) followed by the minimum in neat water (3.91 × 10<sup>−8</sup> at 293.2 K). The values of mean percent deviation (<i>MPD</i>) were estimated as 2.27%, 5.15%, 27.76%, 1.24% and 1.52% for the “Apelblat, van’t Hoff, Yalkowsky–Roseman, Jouyban–Acree, and Jouyban–Acree–van’t Hoff models”, respectively, indicating good correlations. The HSP value of CNZ was closed with that of neat TP, suggesting the maximum solubilization of CNZ in TP compared with neat water and other aqueous mixtures of TP and water. The outcomes of the apparent thermodynamic analysis revealed that CNZ dissolution was endothermic and entropy-driven in all of the {(TP) (1) + water (2)} systems investigated. For {(TP) (1) + water (2)} mixtures, the enthalpy-driven mechanism was determined to be the driven mechanism for CNZ solvation. TP has great potential for solubilizing the weak base, CNZ, in water, as demonstrated by these results.Faiyaz ShakeelMohsin KaziFars K. AlanaziPrawez AlamMDPI AGarticlecinnarizine{Transcutol-P (1) + water (2)} mixturescorrelationsolubilitythermodynamicsOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 7052, p 7052 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cinnarizine {Transcutol-P (1) + water (2)} mixtures correlation solubility thermodynamics Organic chemistry QD241-441
spellingShingle	cinnarizine {Transcutol-P (1) + water (2)} mixtures correlation solubility thermodynamics Organic chemistry QD241-441 Faiyaz Shakeel Mohsin Kazi Fars K. Alanazi Prawez Alam Solubility of Cinnarizine in (Transcutol + Water) Mixtures: Determination, Hansen Solubility Parameters, Correlation, and Thermodynamics
description	Between 293.2 and 313.2 K and at 0.1 MPa, the solubility of the weak base, cinnarizine (CNZ) (3), in various {Transcutol-P (TP) (1) + water (2)} combinations is reported. The Hansen solubility parameters (HSP) of CNZ and various {(TP) (1) + water (2)} mixtures free of CNZ were also predicted using HSPiP software. Five distinct cosolvency-based mathematical models were used to link the experimentally determined solubility data of CNZ. The solubility of CNZ in mole fraction was increased with elevated temperature and TP mass fraction in {(TP) (1) + water (2)} combinations. The maximum solubility of CNZ in mole fraction was achieved in neat TP (5.83 × 10<sup>−2</sup> at 313.2 K) followed by the minimum in neat water (3.91 × 10<sup>−8</sup> at 293.2 K). The values of mean percent deviation (<i>MPD</i>) were estimated as 2.27%, 5.15%, 27.76%, 1.24% and 1.52% for the “Apelblat, van’t Hoff, Yalkowsky–Roseman, Jouyban–Acree, and Jouyban–Acree–van’t Hoff models”, respectively, indicating good correlations. The HSP value of CNZ was closed with that of neat TP, suggesting the maximum solubilization of CNZ in TP compared with neat water and other aqueous mixtures of TP and water. The outcomes of the apparent thermodynamic analysis revealed that CNZ dissolution was endothermic and entropy-driven in all of the {(TP) (1) + water (2)} systems investigated. For {(TP) (1) + water (2)} mixtures, the enthalpy-driven mechanism was determined to be the driven mechanism for CNZ solvation. TP has great potential for solubilizing the weak base, CNZ, in water, as demonstrated by these results.
format	article
author	Faiyaz Shakeel Mohsin Kazi Fars K. Alanazi Prawez Alam
author_facet	Faiyaz Shakeel Mohsin Kazi Fars K. Alanazi Prawez Alam
author_sort	Faiyaz Shakeel
title	Solubility of Cinnarizine in (Transcutol + Water) Mixtures: Determination, Hansen Solubility Parameters, Correlation, and Thermodynamics
title_short	Solubility of Cinnarizine in (Transcutol + Water) Mixtures: Determination, Hansen Solubility Parameters, Correlation, and Thermodynamics
title_full	Solubility of Cinnarizine in (Transcutol + Water) Mixtures: Determination, Hansen Solubility Parameters, Correlation, and Thermodynamics
title_fullStr	Solubility of Cinnarizine in (Transcutol + Water) Mixtures: Determination, Hansen Solubility Parameters, Correlation, and Thermodynamics
title_full_unstemmed	Solubility of Cinnarizine in (Transcutol + Water) Mixtures: Determination, Hansen Solubility Parameters, Correlation, and Thermodynamics
title_sort	solubility of cinnarizine in (transcutol + water) mixtures: determination, hansen solubility parameters, correlation, and thermodynamics
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5cfca3810e054abb969e501f86c7fffb
work_keys_str_mv	AT faiyazshakeel solubilityofcinnarizineintranscutolwatermixturesdeterminationhansensolubilityparameterscorrelationandthermodynamics AT mohsinkazi solubilityofcinnarizineintranscutolwatermixturesdeterminationhansensolubilityparameterscorrelationandthermodynamics AT farskalanazi solubilityofcinnarizineintranscutolwatermixturesdeterminationhansensolubilityparameterscorrelationandthermodynamics AT prawezalam solubilityofcinnarizineintranscutolwatermixturesdeterminationhansensolubilityparameterscorrelationandthermodynamics
_version_	1718411076351033344

Solubility of Cinnarizine in (Transcutol + Water) Mixtures: Determination, Hansen Solubility Parameters, Correlation, and Thermodynamics

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