Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy.

Linezolid is an effective antimicrobial agent to treat methicillin-resistant Staphylococcus aureus (MRSA). Resistance to linezolid due to the cfr gene is described worldwide. The present study aimed to analyze the prevalence of the cfr-mediated linezolid resistance among MRSA clinical isolates in ou...

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Autores principales:	Josep M Sierra, Mariana Camoez, Fe Tubau, Oriol Gasch, Miquel Pujol, Rogelio Martin, M Angeles Domínguez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5d0019d0a10b48f7a71568e24bc1ec4d
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spelling	oai:doaj.org-article:5d0019d0a10b48f7a71568e24bc1ec4d2021-11-18T07:53:14ZLow prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy.1932-620310.1371/journal.pone.0059215https://doaj.org/article/5d0019d0a10b48f7a71568e24bc1ec4d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23554998/?tool=EBIhttps://doaj.org/toc/1932-6203Linezolid is an effective antimicrobial agent to treat methicillin-resistant Staphylococcus aureus (MRSA). Resistance to linezolid due to the cfr gene is described worldwide. The present study aimed to analyze the prevalence of the cfr-mediated linezolid resistance among MRSA clinical isolates in our area. A very low prevalence of cfr mediated linezolid resistance was found: only one bacteremic isolate out of 2 215 screened isolates. The only linezolid resistant isolate arose in a patient, previously colonized by MRSA, following linezolid therapy. Despite the low rate of resistance in our area, ongoing surveillance is advisable to avoid the spread of linezolid resistance.Josep M SierraMariana CamoezFe TubauOriol GaschMiquel PujolRogelio MartinM Angeles DomínguezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e59215 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Josep M Sierra Mariana Camoez Fe Tubau Oriol Gasch Miquel Pujol Rogelio Martin M Angeles Domínguez Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy.
description	Linezolid is an effective antimicrobial agent to treat methicillin-resistant Staphylococcus aureus (MRSA). Resistance to linezolid due to the cfr gene is described worldwide. The present study aimed to analyze the prevalence of the cfr-mediated linezolid resistance among MRSA clinical isolates in our area. A very low prevalence of cfr mediated linezolid resistance was found: only one bacteremic isolate out of 2 215 screened isolates. The only linezolid resistant isolate arose in a patient, previously colonized by MRSA, following linezolid therapy. Despite the low rate of resistance in our area, ongoing surveillance is advisable to avoid the spread of linezolid resistance.
format	article
author	Josep M Sierra Mariana Camoez Fe Tubau Oriol Gasch Miquel Pujol Rogelio Martin M Angeles Domínguez
author_facet	Josep M Sierra Mariana Camoez Fe Tubau Oriol Gasch Miquel Pujol Rogelio Martin M Angeles Domínguez
author_sort	Josep M Sierra
title	Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy.
title_short	Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy.
title_full	Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy.
title_fullStr	Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy.
title_full_unstemmed	Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy.
title_sort	low prevalence of cfr-mediated linezolid resistance among methicillin-resistant staphylococcus aureus in a spanish hospital: case report on linezolid resistance acquired during linezolid therapy.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/5d0019d0a10b48f7a71568e24bc1ec4d
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Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy.

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