Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management

Osteoarthritis (OA) is a common degenerative disease that can lead to persistent pain and motion restriction. In the last decade, stem cells, particularly mesenchymal stem cells (MSCs), have been explored as a potential alternative OA therapy due to their regenerative capacity. Furthermore, it has b...

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Auteurs principaux:	Thu Huyen Nguyen, Chau Minh Duong, Xuan-Hung Nguyen, Uyen Thi Trang Than
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	osteoarthritis extracellular vesicles mesenchymal stem cells chondrocytes inflammation bone homeostasis Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/5d02738539054f50b94a66f13d4f08b5
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spelling	oai:doaj.org-article:5d02738539054f50b94a66f13d4f08b52021-11-25T17:08:33ZMesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management10.3390/cells101128872073-4409https://doaj.org/article/5d02738539054f50b94a66f13d4f08b52021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2887https://doaj.org/toc/2073-4409Osteoarthritis (OA) is a common degenerative disease that can lead to persistent pain and motion restriction. In the last decade, stem cells, particularly mesenchymal stem cells (MSCs), have been explored as a potential alternative OA therapy due to their regenerative capacity. Furthermore, it has been shown that trophic factors enveloped in extracellular vesicles (EVs), including exosomes, are a crucial aspect of MSC-based treatment for OA. Evidently, EVs derived from different MSC sources might rescue the OA phenotype by targeting many biological processes associated with cartilage extracellular matrix (ECM) degradation and exerting protective effects on different joint cell types. Despite this advancement, different studies employing EV treatment for OA have revealed reverse outcomes depending on the EV cargo, cell source, and pathological condition. Hence, in this review, we aim to summarize and discuss the possible effects of MSC-derived EVs based on recent findings at different stages of OA development, including effects on cartilage ECM, chondrocyte biology, osteocytes and bone homeostasis, inflammation, and pain management. Additionally, we discuss further strategies and technical advances for manipulating EVs to specifically target OA to bring the therapy closer to clinical use.Thu Huyen NguyenChau Minh DuongXuan-Hung NguyenUyen Thi Trang ThanMDPI AGarticleosteoarthritisextracellular vesiclesmesenchymal stem cellschondrocytesinflammationbone homeostasisBiology (General)QH301-705.5ENCells, Vol 10, Iss 2887, p 2887 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteoarthritis extracellular vesicles mesenchymal stem cells chondrocytes inflammation bone homeostasis Biology (General) QH301-705.5
spellingShingle	osteoarthritis extracellular vesicles mesenchymal stem cells chondrocytes inflammation bone homeostasis Biology (General) QH301-705.5 Thu Huyen Nguyen Chau Minh Duong Xuan-Hung Nguyen Uyen Thi Trang Than Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management
description	Osteoarthritis (OA) is a common degenerative disease that can lead to persistent pain and motion restriction. In the last decade, stem cells, particularly mesenchymal stem cells (MSCs), have been explored as a potential alternative OA therapy due to their regenerative capacity. Furthermore, it has been shown that trophic factors enveloped in extracellular vesicles (EVs), including exosomes, are a crucial aspect of MSC-based treatment for OA. Evidently, EVs derived from different MSC sources might rescue the OA phenotype by targeting many biological processes associated with cartilage extracellular matrix (ECM) degradation and exerting protective effects on different joint cell types. Despite this advancement, different studies employing EV treatment for OA have revealed reverse outcomes depending on the EV cargo, cell source, and pathological condition. Hence, in this review, we aim to summarize and discuss the possible effects of MSC-derived EVs based on recent findings at different stages of OA development, including effects on cartilage ECM, chondrocyte biology, osteocytes and bone homeostasis, inflammation, and pain management. Additionally, we discuss further strategies and technical advances for manipulating EVs to specifically target OA to bring the therapy closer to clinical use.
format	article
author	Thu Huyen Nguyen Chau Minh Duong Xuan-Hung Nguyen Uyen Thi Trang Than
author_facet	Thu Huyen Nguyen Chau Minh Duong Xuan-Hung Nguyen Uyen Thi Trang Than
author_sort	Thu Huyen Nguyen
title	Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management
title_short	Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management
title_full	Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management
title_fullStr	Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management
title_full_unstemmed	Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management
title_sort	mesenchymal stem cell-derived extracellular vesicles for osteoarthritis treatment: extracellular matrix protection, chondrocyte and osteocyte physiology, pain and inflammation management
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5d02738539054f50b94a66f13d4f08b5
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Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management

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