Role of antiphospholipid antibodies in the diagnosis of antiphospholipid syndrome

The diagnosis of antiphospholipid syndrome (APS) relies on the detection of antiphospholipid antibodies (aPL). Currently, lupus anticoagulant (LA), anticardiolipin (aCL), and antibeta2-glycoprotein I antibodies (aβ2GPI) IgG or IgM are included as laboratory criteria, if persistently present. LAC mea...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Katrien M.J. Devreese, Stéphane Zuily, Pier Luigi Meroni
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Antiphospholipid syndrome Anticardiolipin antibodies Anti-β2 glycoprotein I antibodies Lupus anticoagulant Non-criteria antiphospholipid antibodies Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5d031b1addf445bbbd73a5f46d3bba76
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5d031b1addf445bbbd73a5f46d3bba76
record_format	dspace
spelling	oai:doaj.org-article:5d031b1addf445bbbd73a5f46d3bba762021-11-12T04:46:20ZRole of antiphospholipid antibodies in the diagnosis of antiphospholipid syndrome2589-909010.1016/j.jtauto.2021.100134https://doaj.org/article/5d031b1addf445bbbd73a5f46d3bba762021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S258990902100054Xhttps://doaj.org/toc/2589-9090The diagnosis of antiphospholipid syndrome (APS) relies on the detection of antiphospholipid antibodies (aPL). Currently, lupus anticoagulant (LA), anticardiolipin (aCL), and antibeta2-glycoprotein I antibodies (aβ2GPI) IgG or IgM are included as laboratory criteria, if persistently present. LAC measurement remains a complicated procedure with many pitfalls and interfered by anticoagulant therapy. Solid-phase assays for aCL and aβ2GPI show interassay differences. These methodological issues make the laboratory diagnosis of APS challenging. In the interpretation of aPL.results, antibody profiles help in identifying patients at risk. Other aPL, such as antibodies against the domain I of beta2-glycoprotein (aDI) and antiphosphatidylserine-prothrombin (aPS/PT) antibodies have been studied in the last years and may be useful in risk stratification of APS patients. Because of the methodological shortcomings of immunological and clotting assays, these non-criteria aPL may be useful in patients with incomplete antibody profiles to confirm or exclude the increased risk profile. This manuscript will focus on the laboratory aspects, the clinical relevance of assays and interpretation of aPL results in the diagnosis of APS.Katrien M.J. DevreeseStéphane ZuilyPier Luigi MeroniElsevierarticleAntiphospholipid syndromeAnticardiolipin antibodiesAnti-β2 glycoprotein I antibodiesLupus anticoagulantNon-criteria antiphospholipid antibodiesImmunologic diseases. AllergyRC581-607ENJournal of Translational Autoimmunity, Vol 4, Iss , Pp 100134- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antiphospholipid syndrome Anticardiolipin antibodies Anti-β2 glycoprotein I antibodies Lupus anticoagulant Non-criteria antiphospholipid antibodies Immunologic diseases. Allergy RC581-607
spellingShingle	Antiphospholipid syndrome Anticardiolipin antibodies Anti-β2 glycoprotein I antibodies Lupus anticoagulant Non-criteria antiphospholipid antibodies Immunologic diseases. Allergy RC581-607 Katrien M.J. Devreese Stéphane Zuily Pier Luigi Meroni Role of antiphospholipid antibodies in the diagnosis of antiphospholipid syndrome
description	The diagnosis of antiphospholipid syndrome (APS) relies on the detection of antiphospholipid antibodies (aPL). Currently, lupus anticoagulant (LA), anticardiolipin (aCL), and antibeta2-glycoprotein I antibodies (aβ2GPI) IgG or IgM are included as laboratory criteria, if persistently present. LAC measurement remains a complicated procedure with many pitfalls and interfered by anticoagulant therapy. Solid-phase assays for aCL and aβ2GPI show interassay differences. These methodological issues make the laboratory diagnosis of APS challenging. In the interpretation of aPL.results, antibody profiles help in identifying patients at risk. Other aPL, such as antibodies against the domain I of beta2-glycoprotein (aDI) and antiphosphatidylserine-prothrombin (aPS/PT) antibodies have been studied in the last years and may be useful in risk stratification of APS patients. Because of the methodological shortcomings of immunological and clotting assays, these non-criteria aPL may be useful in patients with incomplete antibody profiles to confirm or exclude the increased risk profile. This manuscript will focus on the laboratory aspects, the clinical relevance of assays and interpretation of aPL results in the diagnosis of APS.
format	article
author	Katrien M.J. Devreese Stéphane Zuily Pier Luigi Meroni
author_facet	Katrien M.J. Devreese Stéphane Zuily Pier Luigi Meroni
author_sort	Katrien M.J. Devreese
title	Role of antiphospholipid antibodies in the diagnosis of antiphospholipid syndrome
title_short	Role of antiphospholipid antibodies in the diagnosis of antiphospholipid syndrome
title_full	Role of antiphospholipid antibodies in the diagnosis of antiphospholipid syndrome
title_fullStr	Role of antiphospholipid antibodies in the diagnosis of antiphospholipid syndrome
title_full_unstemmed	Role of antiphospholipid antibodies in the diagnosis of antiphospholipid syndrome
title_sort	role of antiphospholipid antibodies in the diagnosis of antiphospholipid syndrome
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/5d031b1addf445bbbd73a5f46d3bba76
work_keys_str_mv	AT katrienmjdevreese roleofantiphospholipidantibodiesinthediagnosisofantiphospholipidsyndrome AT stephanezuily roleofantiphospholipidantibodiesinthediagnosisofantiphospholipidsyndrome AT pierluigimeroni roleofantiphospholipidantibodiesinthediagnosisofantiphospholipidsyndrome
_version_	1718431232538181632

Role of antiphospholipid antibodies in the diagnosis of antiphospholipid syndrome

Ejemplares similares