Pharmacognostic Study on <i>Elsholtzia ciliata</i> (Thumb.) Hyl: Anatomy, Phytochemistry and Pharmacological Activities

<i>Elsholtzia ciliata</i> (Thunb.) Hyl, family Lamiaceae, is an important and popular anti-bacterial and anti-inflammatory Traditional Chinese Medicine (TCM). However, there are limited scientific studies on its anatomy and pharmacological activities. Moreover, the information of chemica...

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Autores principales:	Qian Zhang, Niara Moura Porto, Carolina Carvalho Guilhon, Thais Biondino Sardella Giorno, Daniela Sales Alviano, Maria de Fatima Agra, Patricia Dias Fernandes, Fabio Boylan
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Elsholtzia ciliata</i> botanical identification chemical analysis anti-inflammatory activity quality control Traditional Chinese Medicine Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/5d06b5a79ce74ddabeca97dac7281b7d
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spelling	oai:doaj.org-article:5d06b5a79ce74ddabeca97dac7281b7d2021-11-25T18:39:45ZPharmacognostic Study on <i>Elsholtzia ciliata</i> (Thumb.) Hyl: Anatomy, Phytochemistry and Pharmacological Activities10.3390/ph141111521424-8247https://doaj.org/article/5d06b5a79ce74ddabeca97dac7281b7d2021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1152https://doaj.org/toc/1424-8247<i>Elsholtzia ciliata</i> (Thunb.) Hyl, family Lamiaceae, is an important and popular anti-bacterial and anti-inflammatory Traditional Chinese Medicine (TCM). However, there are limited scientific studies on its anatomy and pharmacological activities. Moreover, the information of chemical constituents in relation to its non-volatile constituents are still missing. The current study aimed to evaluate the anatomic, pharmacological and phytochemical profile of <i>Elsholtzia ciliata</i>, providing means for the quality control of this herbal drug. The methodology designed for this study included the preparation of anatomic sections and their description, extraction, chromatography, structural elucidation of isolated compounds by NMR techniques and their quantification by HPLC using pharmacological assays (Formalin, hot plate, DPPH, antimicrobial-Gram positive, Gram Negative and fungus, and MTT assays) to confirm the activities described for this species. Results of the anatomic study are aligned with the pattern expected for plants belonging to the Lamiaceae family; Ursolic acid and Oroxylin were isolated from this plant species. The findings observed in this study indicate that <i>Elsholtzia ciliata</i> possess anti-inflammatory, antinociceptive, antioxidant, antimicrobial and anticancer activities. The chemical compounds isolated from its leaves and the anatomy profile of its parts provide the basis for further quality control for this plant.Qian ZhangNiara Moura PortoCarolina Carvalho GuilhonThais Biondino Sardella GiornoDaniela Sales AlvianoMaria de Fatima AgraPatricia Dias FernandesFabio BoylanMDPI AGarticle<i>Elsholtzia ciliata</i>botanical identificationchemical analysisanti-inflammatory activityquality controlTraditional Chinese MedicineMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1152, p 1152 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Elsholtzia ciliata</i> botanical identification chemical analysis anti-inflammatory activity quality control Traditional Chinese Medicine Medicine R Pharmacy and materia medica RS1-441
spellingShingle	<i>Elsholtzia ciliata</i> botanical identification chemical analysis anti-inflammatory activity quality control Traditional Chinese Medicine Medicine R Pharmacy and materia medica RS1-441 Qian Zhang Niara Moura Porto Carolina Carvalho Guilhon Thais Biondino Sardella Giorno Daniela Sales Alviano Maria de Fatima Agra Patricia Dias Fernandes Fabio Boylan Pharmacognostic Study on <i>Elsholtzia ciliata</i> (Thumb.) Hyl: Anatomy, Phytochemistry and Pharmacological Activities
description	<i>Elsholtzia ciliata</i> (Thunb.) Hyl, family Lamiaceae, is an important and popular anti-bacterial and anti-inflammatory Traditional Chinese Medicine (TCM). However, there are limited scientific studies on its anatomy and pharmacological activities. Moreover, the information of chemical constituents in relation to its non-volatile constituents are still missing. The current study aimed to evaluate the anatomic, pharmacological and phytochemical profile of <i>Elsholtzia ciliata</i>, providing means for the quality control of this herbal drug. The methodology designed for this study included the preparation of anatomic sections and their description, extraction, chromatography, structural elucidation of isolated compounds by NMR techniques and their quantification by HPLC using pharmacological assays (Formalin, hot plate, DPPH, antimicrobial-Gram positive, Gram Negative and fungus, and MTT assays) to confirm the activities described for this species. Results of the anatomic study are aligned with the pattern expected for plants belonging to the Lamiaceae family; Ursolic acid and Oroxylin were isolated from this plant species. The findings observed in this study indicate that <i>Elsholtzia ciliata</i> possess anti-inflammatory, antinociceptive, antioxidant, antimicrobial and anticancer activities. The chemical compounds isolated from its leaves and the anatomy profile of its parts provide the basis for further quality control for this plant.
format	article
author	Qian Zhang Niara Moura Porto Carolina Carvalho Guilhon Thais Biondino Sardella Giorno Daniela Sales Alviano Maria de Fatima Agra Patricia Dias Fernandes Fabio Boylan
author_facet	Qian Zhang Niara Moura Porto Carolina Carvalho Guilhon Thais Biondino Sardella Giorno Daniela Sales Alviano Maria de Fatima Agra Patricia Dias Fernandes Fabio Boylan
author_sort	Qian Zhang
title	Pharmacognostic Study on <i>Elsholtzia ciliata</i> (Thumb.) Hyl: Anatomy, Phytochemistry and Pharmacological Activities
title_short	Pharmacognostic Study on <i>Elsholtzia ciliata</i> (Thumb.) Hyl: Anatomy, Phytochemistry and Pharmacological Activities
title_full	Pharmacognostic Study on <i>Elsholtzia ciliata</i> (Thumb.) Hyl: Anatomy, Phytochemistry and Pharmacological Activities
title_fullStr	Pharmacognostic Study on <i>Elsholtzia ciliata</i> (Thumb.) Hyl: Anatomy, Phytochemistry and Pharmacological Activities
title_full_unstemmed	Pharmacognostic Study on <i>Elsholtzia ciliata</i> (Thumb.) Hyl: Anatomy, Phytochemistry and Pharmacological Activities
title_sort	pharmacognostic study on <i>elsholtzia ciliata</i> (thumb.) hyl: anatomy, phytochemistry and pharmacological activities
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5d06b5a79ce74ddabeca97dac7281b7d
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Pharmacognostic Study on <i>Elsholtzia ciliata</i> (Thumb.) Hyl: Anatomy, Phytochemistry and Pharmacological Activities

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