Human Papillomavirus Oral Infection: Review of Methodological Aspects and Epidemiology

Oral infection by Human Papillomavirus (HPV) has recently gained great attention because of its involvement in the development of a subset of head and neck squamous cell carcinoma. The role of specific Alpha-HPVs in this regard has been well established, whereas the contribution of other genera is u...

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Autores principales:	Eugenia Giuliani, Francesca Rollo, Maria Gabriella Donà, Anna Rosa Garbuglia
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Human Papillomavirus Alphapapillomavirus Betapapillomavirus Gammapapillomavirus detection method oral infection Medicine R
Acceso en línea:	https://doaj.org/article/5d075d8762a34cf1be062c228581432e
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spelling	oai:doaj.org-article:5d075d8762a34cf1be062c228581432e2021-11-25T18:38:03ZHuman Papillomavirus Oral Infection: Review of Methodological Aspects and Epidemiology10.3390/pathogens101114112076-0817https://doaj.org/article/5d075d8762a34cf1be062c228581432e2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1411https://doaj.org/toc/2076-0817Oral infection by Human Papillomavirus (HPV) has recently gained great attention because of its involvement in the development of a subset of head and neck squamous cell carcinoma. The role of specific Alpha-HPVs in this regard has been well established, whereas the contribution of other genera is under investigation. Despite their traditional classification as “cutaneous” types, Beta and Gamma HPVs are frequently detected in oral samples. Due to the lack of a standardized protocol, a large variety of methodologies have been used for oral sample collection, DNA extraction, HPV detection and genotyping. Laboratory procedures influence the evaluation of oral HPV prevalence, which largely varies also according to the population characteristics, e.g., age, gender, sexual behavior, Human Immunodeficiency Virus (HIV) status. Nevertheless, oral infection by Beta and Gamma HPVs seems to be even more common than Alpha-HPVs. The latter is 5–7% in the general population, and increases up to 30% approximately in HIV-infected men who have sex with men. Despite major advances in the evaluation of oral HPV prevalence, its natural history is still little understood, especially for Beta and Gamma HPVs. The latest technologies, such as Next Generation Sequencing (NGS), can be exploited to gain new insights into oral HPV, and to improve the identification of novel HPV types.Eugenia GiulianiFrancesca RolloMaria Gabriella DonàAnna Rosa GarbugliaMDPI AGarticleHuman PapillomavirusAlphapapillomavirusBetapapillomavirusGammapapillomavirusdetection methodoral infectionMedicineRENPathogens, Vol 10, Iss 1411, p 1411 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Human Papillomavirus Alphapapillomavirus Betapapillomavirus Gammapapillomavirus detection method oral infection Medicine R
spellingShingle	Human Papillomavirus Alphapapillomavirus Betapapillomavirus Gammapapillomavirus detection method oral infection Medicine R Eugenia Giuliani Francesca Rollo Maria Gabriella Donà Anna Rosa Garbuglia Human Papillomavirus Oral Infection: Review of Methodological Aspects and Epidemiology
description	Oral infection by Human Papillomavirus (HPV) has recently gained great attention because of its involvement in the development of a subset of head and neck squamous cell carcinoma. The role of specific Alpha-HPVs in this regard has been well established, whereas the contribution of other genera is under investigation. Despite their traditional classification as “cutaneous” types, Beta and Gamma HPVs are frequently detected in oral samples. Due to the lack of a standardized protocol, a large variety of methodologies have been used for oral sample collection, DNA extraction, HPV detection and genotyping. Laboratory procedures influence the evaluation of oral HPV prevalence, which largely varies also according to the population characteristics, e.g., age, gender, sexual behavior, Human Immunodeficiency Virus (HIV) status. Nevertheless, oral infection by Beta and Gamma HPVs seems to be even more common than Alpha-HPVs. The latter is 5–7% in the general population, and increases up to 30% approximately in HIV-infected men who have sex with men. Despite major advances in the evaluation of oral HPV prevalence, its natural history is still little understood, especially for Beta and Gamma HPVs. The latest technologies, such as Next Generation Sequencing (NGS), can be exploited to gain new insights into oral HPV, and to improve the identification of novel HPV types.
format	article
author	Eugenia Giuliani Francesca Rollo Maria Gabriella Donà Anna Rosa Garbuglia
author_facet	Eugenia Giuliani Francesca Rollo Maria Gabriella Donà Anna Rosa Garbuglia
author_sort	Eugenia Giuliani
title	Human Papillomavirus Oral Infection: Review of Methodological Aspects and Epidemiology
title_short	Human Papillomavirus Oral Infection: Review of Methodological Aspects and Epidemiology
title_full	Human Papillomavirus Oral Infection: Review of Methodological Aspects and Epidemiology
title_fullStr	Human Papillomavirus Oral Infection: Review of Methodological Aspects and Epidemiology
title_full_unstemmed	Human Papillomavirus Oral Infection: Review of Methodological Aspects and Epidemiology
title_sort	human papillomavirus oral infection: review of methodological aspects and epidemiology
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5d075d8762a34cf1be062c228581432e
work_keys_str_mv	AT eugeniagiuliani humanpapillomavirusoralinfectionreviewofmethodologicalaspectsandepidemiology AT francescarollo humanpapillomavirusoralinfectionreviewofmethodologicalaspectsandepidemiology AT mariagabrielladona humanpapillomavirusoralinfectionreviewofmethodologicalaspectsandepidemiology AT annarosagarbuglia humanpapillomavirusoralinfectionreviewofmethodologicalaspectsandepidemiology
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Human Papillomavirus Oral Infection: Review of Methodological Aspects and Epidemiology

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