Risk of venous thromboembolism in Asian patients with inflammatory bowel disease: a nationwide cohort study

Abstract Routine prophylaxis for venous thromboembolism (VTE) in Asian IBD patients has been controversial. We aimed to estimate the risk of VTE of Asian patients at different phases of IBD by incorporating patient-specific risk factors. In this cohort study, we analyzed the National Health Insuranc...

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Autores principales:	Chan Mi Heo, Tae Jun Kim, Eun Ran Kim, Sung Noh Hong, Dong Kyung Chang, Mi Yang, Seonwoo Kim, Young-Ho Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5d09e1b65fac41d4b6c2aa42dbc4efab
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spelling	oai:doaj.org-article:5d09e1b65fac41d4b6c2aa42dbc4efab2021-12-02T14:09:01ZRisk of venous thromboembolism in Asian patients with inflammatory bowel disease: a nationwide cohort study10.1038/s41598-021-81657-y2045-2322https://doaj.org/article/5d09e1b65fac41d4b6c2aa42dbc4efab2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81657-yhttps://doaj.org/toc/2045-2322Abstract Routine prophylaxis for venous thromboembolism (VTE) in Asian IBD patients has been controversial. We aimed to estimate the risk of VTE of Asian patients at different phases of IBD by incorporating patient-specific risk factors. In this cohort study, we analyzed the National Health Insurance claims data between 2012 and 2016 for the entire Korean population. We calculated incidence rates and hazard ratios for VTE. The overall VTE risk was higher in patients with IBD [adjusted hazard ratio (aHR), 2.06; 95% confidence interval (CI), 1.66–2.55], than in controls. When we compare the risk of VTE by different disease phases, the risk of VTE was the highest during post-operation period after IBD-related bowel surgery (aHR, 39.7; 95% CI 9.87–159.3), followed by during hospitalized periods with flare (aHR, 27.2; 95% CI 14.9–49.65) and during hospitalized periods with non-flare (aHR, 16.23; 95% CI 10.71–24.58). The incidence rate (per 1000 person-years) was 15.26 during hospitalized periods with a flare and 9.83 during hospitalized periods with non-flare. According to age groups, the incidence rate (per 1000 person-years) during hospitalized periods with flare was 14.53 in young patients (20–39 years) and 34.58 in older patients (60–80 years). During hospitalized periods with non-flare, the incidence rate was 3.55 in young patients and 23.61 in older patients. The prophylaxis of VTE for Asian patients with IBD should be recommended in older patients admitted to hospital and be considered in young patients who are hospitalized with a flare.Chan Mi HeoTae Jun KimEun Ran KimSung Noh HongDong Kyung ChangMi YangSeonwoo KimYoung-Ho KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chan Mi Heo Tae Jun Kim Eun Ran Kim Sung Noh Hong Dong Kyung Chang Mi Yang Seonwoo Kim Young-Ho Kim Risk of venous thromboembolism in Asian patients with inflammatory bowel disease: a nationwide cohort study
description	Abstract Routine prophylaxis for venous thromboembolism (VTE) in Asian IBD patients has been controversial. We aimed to estimate the risk of VTE of Asian patients at different phases of IBD by incorporating patient-specific risk factors. In this cohort study, we analyzed the National Health Insurance claims data between 2012 and 2016 for the entire Korean population. We calculated incidence rates and hazard ratios for VTE. The overall VTE risk was higher in patients with IBD [adjusted hazard ratio (aHR), 2.06; 95% confidence interval (CI), 1.66–2.55], than in controls. When we compare the risk of VTE by different disease phases, the risk of VTE was the highest during post-operation period after IBD-related bowel surgery (aHR, 39.7; 95% CI 9.87–159.3), followed by during hospitalized periods with flare (aHR, 27.2; 95% CI 14.9–49.65) and during hospitalized periods with non-flare (aHR, 16.23; 95% CI 10.71–24.58). The incidence rate (per 1000 person-years) was 15.26 during hospitalized periods with a flare and 9.83 during hospitalized periods with non-flare. According to age groups, the incidence rate (per 1000 person-years) during hospitalized periods with flare was 14.53 in young patients (20–39 years) and 34.58 in older patients (60–80 years). During hospitalized periods with non-flare, the incidence rate was 3.55 in young patients and 23.61 in older patients. The prophylaxis of VTE for Asian patients with IBD should be recommended in older patients admitted to hospital and be considered in young patients who are hospitalized with a flare.
format	article
author	Chan Mi Heo Tae Jun Kim Eun Ran Kim Sung Noh Hong Dong Kyung Chang Mi Yang Seonwoo Kim Young-Ho Kim
author_facet	Chan Mi Heo Tae Jun Kim Eun Ran Kim Sung Noh Hong Dong Kyung Chang Mi Yang Seonwoo Kim Young-Ho Kim
author_sort	Chan Mi Heo
title	Risk of venous thromboembolism in Asian patients with inflammatory bowel disease: a nationwide cohort study
title_short	Risk of venous thromboembolism in Asian patients with inflammatory bowel disease: a nationwide cohort study
title_full	Risk of venous thromboembolism in Asian patients with inflammatory bowel disease: a nationwide cohort study
title_fullStr	Risk of venous thromboembolism in Asian patients with inflammatory bowel disease: a nationwide cohort study
title_full_unstemmed	Risk of venous thromboembolism in Asian patients with inflammatory bowel disease: a nationwide cohort study
title_sort	risk of venous thromboembolism in asian patients with inflammatory bowel disease: a nationwide cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5d09e1b65fac41d4b6c2aa42dbc4efab
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Risk of venous thromboembolism in Asian patients with inflammatory bowel disease: a nationwide cohort study

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