Roles of Integrins in Gastrointestinal Cancer Metastasis

Integrins are a large family of heterodimeric transmembrane receptors which mediate cell adhesion and transmit signals to the cell interior. The mechanistic roles of integrins have long been an enigma in cancer, given its complexity in regulating different cellular behaviors. Recently, however, incr...

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Autores principales:	Sicong Hou, Jiaxin Wang, Wenqian Li, Xin Hao, Qinglei Hang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	integrin EMT transcription factors cell signalings gastric cancer colorectal cancer Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5d0bb8ff3d644834b7a13ae8e268c23f
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spelling	oai:doaj.org-article:5d0bb8ff3d644834b7a13ae8e268c23f2021-11-15T06:49:27ZRoles of Integrins in Gastrointestinal Cancer Metastasis2296-889X10.3389/fmolb.2021.708779https://doaj.org/article/5d0bb8ff3d644834b7a13ae8e268c23f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.708779/fullhttps://doaj.org/toc/2296-889XIntegrins are a large family of heterodimeric transmembrane receptors which mediate cell adhesion and transmit signals to the cell interior. The mechanistic roles of integrins have long been an enigma in cancer, given its complexity in regulating different cellular behaviors. Recently, however, increasing research is providing new insights into its function and the underlying mechanisms, which collectively include the influences of altered integrin expression on the aberrant signaling pathways and cancer progression. Many studies have also demonstrated the potentiality of integrins as therapeutic targets in cancer treatment. In this review, we have summarized these recent reports and put a particular emphasis on the dysregulated expression of integrins and how they regulate related signaling pathways to facilitate the metastatic progression of gastrointestinal cancer, including gastric cancer (GC) and colorectal cancer (CRC), which will address the crucial roles of integrins in gastrointestinal cancer.Sicong HouJiaxin WangWenqian LiXin HaoQinglei HangFrontiers Media S.A.articleintegrinEMTtranscription factorscell signalingsgastric cancercolorectal cancerBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	integrin EMT transcription factors cell signalings gastric cancer colorectal cancer Biology (General) QH301-705.5
spellingShingle	integrin EMT transcription factors cell signalings gastric cancer colorectal cancer Biology (General) QH301-705.5 Sicong Hou Jiaxin Wang Wenqian Li Xin Hao Qinglei Hang Roles of Integrins in Gastrointestinal Cancer Metastasis
description	Integrins are a large family of heterodimeric transmembrane receptors which mediate cell adhesion and transmit signals to the cell interior. The mechanistic roles of integrins have long been an enigma in cancer, given its complexity in regulating different cellular behaviors. Recently, however, increasing research is providing new insights into its function and the underlying mechanisms, which collectively include the influences of altered integrin expression on the aberrant signaling pathways and cancer progression. Many studies have also demonstrated the potentiality of integrins as therapeutic targets in cancer treatment. In this review, we have summarized these recent reports and put a particular emphasis on the dysregulated expression of integrins and how they regulate related signaling pathways to facilitate the metastatic progression of gastrointestinal cancer, including gastric cancer (GC) and colorectal cancer (CRC), which will address the crucial roles of integrins in gastrointestinal cancer.
format	article
author	Sicong Hou Jiaxin Wang Wenqian Li Xin Hao Qinglei Hang
author_facet	Sicong Hou Jiaxin Wang Wenqian Li Xin Hao Qinglei Hang
author_sort	Sicong Hou
title	Roles of Integrins in Gastrointestinal Cancer Metastasis
title_short	Roles of Integrins in Gastrointestinal Cancer Metastasis
title_full	Roles of Integrins in Gastrointestinal Cancer Metastasis
title_fullStr	Roles of Integrins in Gastrointestinal Cancer Metastasis
title_full_unstemmed	Roles of Integrins in Gastrointestinal Cancer Metastasis
title_sort	roles of integrins in gastrointestinal cancer metastasis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5d0bb8ff3d644834b7a13ae8e268c23f
work_keys_str_mv	AT siconghou rolesofintegrinsingastrointestinalcancermetastasis AT jiaxinwang rolesofintegrinsingastrointestinalcancermetastasis AT wenqianli rolesofintegrinsingastrointestinalcancermetastasis AT xinhao rolesofintegrinsingastrointestinalcancermetastasis AT qingleihang rolesofintegrinsingastrointestinalcancermetastasis
_version_	1718428554002169856

Roles of Integrins in Gastrointestinal Cancer Metastasis

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