Gastric Microbiota beyond <i>H. pylori</i>: An Emerging Critical Character in Gastric Carcinogenesis

Gastric cancer (GC) is one of the global leading causes of cancer death. The association between <i>Helicobacter pylori</i>, which is a predominant risk factor for GC, with GC development has been well-studied. Recently, accumulating evidence has demonstrated the presence of a large popu...

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Autores principales:	Jun Wen, Harry Cheuk-Hay Lau, Maikel Peppelenbosch, Jun Yu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	gastric microbiota gastric carcinogenesis gastric dysbiosis non-<i>H. pylori</i> commensals microbiota-related carcinogenesis diagnostic biomarker Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5d0d18c0936d42a88e815c6778ecbbbf
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spelling	oai:doaj.org-article:5d0d18c0936d42a88e815c6778ecbbbf2021-11-25T16:50:44ZGastric Microbiota beyond <i>H. pylori</i>: An Emerging Critical Character in Gastric Carcinogenesis10.3390/biomedicines91116802227-9059https://doaj.org/article/5d0d18c0936d42a88e815c6778ecbbbf2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1680https://doaj.org/toc/2227-9059Gastric cancer (GC) is one of the global leading causes of cancer death. The association between <i>Helicobacter pylori</i>, which is a predominant risk factor for GC, with GC development has been well-studied. Recently, accumulating evidence has demonstrated the presence of a large population of microorganisms other than <i>H. pylori</i> in the human stomach. Existing sequencing studies have revealed microbial compositional and functional alterations in patients with GC and highlighted a progressive shift in the gastric microbiota in gastric carcinogenesis with marked enrichments of oral or intestinal commensals. Moreover, using a combination of gastric bacterial signatures, GC patients could be significantly distinguished from patients with gastritis. These findings, therefore, emphasize the importance of a collective microbial community in gastric carcinogenesis. Here, we provide an overview of non-<i>H. pylori</i> gastric microbes in gastric carcinogenesis. The molecular mechanisms of gastric microbes-related carcinogenesis and potential clinical applications of gastric microbiota as biomarkers of GC are also explored.Jun WenHarry Cheuk-Hay LauMaikel PeppelenboschJun YuMDPI AGarticlegastric microbiotagastric carcinogenesisgastric dysbiosisnon-<i>H. pylori</i> commensalsmicrobiota-related carcinogenesisdiagnostic biomarkerBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1680, p 1680 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gastric microbiota gastric carcinogenesis gastric dysbiosis non-<i>H. pylori</i> commensals microbiota-related carcinogenesis diagnostic biomarker Biology (General) QH301-705.5
spellingShingle	gastric microbiota gastric carcinogenesis gastric dysbiosis non-<i>H. pylori</i> commensals microbiota-related carcinogenesis diagnostic biomarker Biology (General) QH301-705.5 Jun Wen Harry Cheuk-Hay Lau Maikel Peppelenbosch Jun Yu Gastric Microbiota beyond <i>H. pylori</i>: An Emerging Critical Character in Gastric Carcinogenesis
description	Gastric cancer (GC) is one of the global leading causes of cancer death. The association between <i>Helicobacter pylori</i>, which is a predominant risk factor for GC, with GC development has been well-studied. Recently, accumulating evidence has demonstrated the presence of a large population of microorganisms other than <i>H. pylori</i> in the human stomach. Existing sequencing studies have revealed microbial compositional and functional alterations in patients with GC and highlighted a progressive shift in the gastric microbiota in gastric carcinogenesis with marked enrichments of oral or intestinal commensals. Moreover, using a combination of gastric bacterial signatures, GC patients could be significantly distinguished from patients with gastritis. These findings, therefore, emphasize the importance of a collective microbial community in gastric carcinogenesis. Here, we provide an overview of non-<i>H. pylori</i> gastric microbes in gastric carcinogenesis. The molecular mechanisms of gastric microbes-related carcinogenesis and potential clinical applications of gastric microbiota as biomarkers of GC are also explored.
format	article
author	Jun Wen Harry Cheuk-Hay Lau Maikel Peppelenbosch Jun Yu
author_facet	Jun Wen Harry Cheuk-Hay Lau Maikel Peppelenbosch Jun Yu
author_sort	Jun Wen
title	Gastric Microbiota beyond <i>H. pylori</i>: An Emerging Critical Character in Gastric Carcinogenesis
title_short	Gastric Microbiota beyond <i>H. pylori</i>: An Emerging Critical Character in Gastric Carcinogenesis
title_full	Gastric Microbiota beyond <i>H. pylori</i>: An Emerging Critical Character in Gastric Carcinogenesis
title_fullStr	Gastric Microbiota beyond <i>H. pylori</i>: An Emerging Critical Character in Gastric Carcinogenesis
title_full_unstemmed	Gastric Microbiota beyond <i>H. pylori</i>: An Emerging Critical Character in Gastric Carcinogenesis
title_sort	gastric microbiota beyond <i>h. pylori</i>: an emerging critical character in gastric carcinogenesis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5d0d18c0936d42a88e815c6778ecbbbf
work_keys_str_mv	AT junwen gastricmicrobiotabeyondihpyloriianemergingcriticalcharacteringastriccarcinogenesis AT harrycheukhaylau gastricmicrobiotabeyondihpyloriianemergingcriticalcharacteringastriccarcinogenesis AT maikelpeppelenbosch gastricmicrobiotabeyondihpyloriianemergingcriticalcharacteringastriccarcinogenesis AT junyu gastricmicrobiotabeyondihpyloriianemergingcriticalcharacteringastriccarcinogenesis
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Gastric Microbiota beyond <i>H. pylori</i>: An Emerging Critical Character in Gastric Carcinogenesis

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