Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals

Abstract The combination of substance use and psychiatric disorders is one of the most common comorbidities. The objective of this study was to perform a genome-wide association study of this comorbidity (Com), substance use alone (Subs), and psychiatric symptomatology alone (Psych) in the Mexican p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	José Jaime Martínez-Magaña, Alma Delia Genis-Mendoza, Jorge Ameth Villatoro Velázquez, Marycarmen Bustos-Gamiño, Isela Esther Juárez-Rojop, Carlos Alfonso Tovilla-Zarate, Emmanuel Sarmiento, Erasmo Saucedo, Oscar Rodríguez-Mayoral, Clara Fleiz-Bautista, Beatriz Camarena, Alejandro Aguilar, Thelma Beatriz Gonzalez-Castro, María Elena Medina-Mora, Humberto Nicolini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5d0de1350d854eb985e2b7bbec0f13ec
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5d0de1350d854eb985e2b7bbec0f13ec
record_format	dspace
spelling	oai:doaj.org-article:5d0de1350d854eb985e2b7bbec0f13ec2021-12-02T17:04:33ZGenome-wide association study of psychiatric and substance use comorbidity in Mexican individuals10.1038/s41598-021-85881-42045-2322https://doaj.org/article/5d0de1350d854eb985e2b7bbec0f13ec2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85881-4https://doaj.org/toc/2045-2322Abstract The combination of substance use and psychiatric disorders is one of the most common comorbidities. The objective of this study was to perform a genome-wide association study of this comorbidity (Com), substance use alone (Subs), and psychiatric symptomatology alone (Psych) in the Mexican population. The study included 3914 individuals of Mexican descent. Genotyping was carried out using the PsychArray microarray and genome-wide correlations were calculated. Genome-wide associations were analyzed using multiple logistic models, polygenic risk scores (PRSs) were evaluated using multinomial models, and vertical pleiotropy was evaluated by generalized summary-data-based Mendelian randomization. Brain DNA methylation quantitative loci (brain meQTL) were also evaluated in the prefrontal cortex. Genome-wide correlation and vertical pleiotropy were found between all traits. No genome-wide association signals were found, but 64 single-nucleotide polymorphism (SNPs) reached nominal associations (p < 5.00e−05). The SNPs associated with each trait were independent, and the individuals with high PRSs had a higher prevalence of tobacco and alcohol use. In the multinomial models all of the PRSs (Subs-PRS, Com-PRS, and Psych-PRS) were associated with all of the traits. Brain meQTL of the Subs-associated SNPs had an effect on the genes enriched in insulin signaling pathway, and that of the Psych-associated SNPs had an effect on the Fc gamma receptor phagocytosis pathway.José Jaime Martínez-MagañaAlma Delia Genis-MendozaJorge Ameth Villatoro VelázquezMarycarmen Bustos-GamiñoIsela Esther Juárez-RojopCarlos Alfonso Tovilla-ZarateEmmanuel SarmientoErasmo SaucedoOscar Rodríguez-MayoralClara Fleiz-BautistaBeatriz CamarenaAlejandro AguilarThelma Beatriz Gonzalez-CastroMaría Elena Medina-MoraHumberto NicoliniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q José Jaime Martínez-Magaña Alma Delia Genis-Mendoza Jorge Ameth Villatoro Velázquez Marycarmen Bustos-Gamiño Isela Esther Juárez-Rojop Carlos Alfonso Tovilla-Zarate Emmanuel Sarmiento Erasmo Saucedo Oscar Rodríguez-Mayoral Clara Fleiz-Bautista Beatriz Camarena Alejandro Aguilar Thelma Beatriz Gonzalez-Castro María Elena Medina-Mora Humberto Nicolini Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals
description	Abstract The combination of substance use and psychiatric disorders is one of the most common comorbidities. The objective of this study was to perform a genome-wide association study of this comorbidity (Com), substance use alone (Subs), and psychiatric symptomatology alone (Psych) in the Mexican population. The study included 3914 individuals of Mexican descent. Genotyping was carried out using the PsychArray microarray and genome-wide correlations were calculated. Genome-wide associations were analyzed using multiple logistic models, polygenic risk scores (PRSs) were evaluated using multinomial models, and vertical pleiotropy was evaluated by generalized summary-data-based Mendelian randomization. Brain DNA methylation quantitative loci (brain meQTL) were also evaluated in the prefrontal cortex. Genome-wide correlation and vertical pleiotropy were found between all traits. No genome-wide association signals were found, but 64 single-nucleotide polymorphism (SNPs) reached nominal associations (p < 5.00e−05). The SNPs associated with each trait were independent, and the individuals with high PRSs had a higher prevalence of tobacco and alcohol use. In the multinomial models all of the PRSs (Subs-PRS, Com-PRS, and Psych-PRS) were associated with all of the traits. Brain meQTL of the Subs-associated SNPs had an effect on the genes enriched in insulin signaling pathway, and that of the Psych-associated SNPs had an effect on the Fc gamma receptor phagocytosis pathway.
format	article
author	José Jaime Martínez-Magaña Alma Delia Genis-Mendoza Jorge Ameth Villatoro Velázquez Marycarmen Bustos-Gamiño Isela Esther Juárez-Rojop Carlos Alfonso Tovilla-Zarate Emmanuel Sarmiento Erasmo Saucedo Oscar Rodríguez-Mayoral Clara Fleiz-Bautista Beatriz Camarena Alejandro Aguilar Thelma Beatriz Gonzalez-Castro María Elena Medina-Mora Humberto Nicolini
author_facet	José Jaime Martínez-Magaña Alma Delia Genis-Mendoza Jorge Ameth Villatoro Velázquez Marycarmen Bustos-Gamiño Isela Esther Juárez-Rojop Carlos Alfonso Tovilla-Zarate Emmanuel Sarmiento Erasmo Saucedo Oscar Rodríguez-Mayoral Clara Fleiz-Bautista Beatriz Camarena Alejandro Aguilar Thelma Beatriz Gonzalez-Castro María Elena Medina-Mora Humberto Nicolini
author_sort	José Jaime Martínez-Magaña
title	Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals
title_short	Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals
title_full	Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals
title_fullStr	Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals
title_full_unstemmed	Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals
title_sort	genome-wide association study of psychiatric and substance use comorbidity in mexican individuals
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5d0de1350d854eb985e2b7bbec0f13ec
work_keys_str_mv	AT josejaimemartinezmagana genomewideassociationstudyofpsychiatricandsubstanceusecomorbidityinmexicanindividuals AT almadeliagenismendoza genomewideassociationstudyofpsychiatricandsubstanceusecomorbidityinmexicanindividuals AT jorgeamethvillatorovelazquez genomewideassociationstudyofpsychiatricandsubstanceusecomorbidityinmexicanindividuals AT marycarmenbustosgamino genomewideassociationstudyofpsychiatricandsubstanceusecomorbidityinmexicanindividuals AT iselaestherjuarezrojop genomewideassociationstudyofpsychiatricandsubstanceusecomorbidityinmexicanindividuals AT carlosalfonsotovillazarate genomewideassociationstudyofpsychiatricandsubstanceusecomorbidityinmexicanindividuals AT emmanuelsarmiento genomewideassociationstudyofpsychiatricandsubstanceusecomorbidityinmexicanindividuals AT erasmosaucedo genomewideassociationstudyofpsychiatricandsubstanceusecomorbidityinmexicanindividuals AT oscarrodriguezmayoral genomewideassociationstudyofpsychiatricandsubstanceusecomorbidityinmexicanindividuals AT clarafleizbautista genomewideassociationstudyofpsychiatricandsubstanceusecomorbidityinmexicanindividuals AT beatrizcamarena genomewideassociationstudyofpsychiatricandsubstanceusecomorbidityinmexicanindividuals AT alejandroaguilar genomewideassociationstudyofpsychiatricandsubstanceusecomorbidityinmexicanindividuals AT thelmabeatrizgonzalezcastro genomewideassociationstudyofpsychiatricandsubstanceusecomorbidityinmexicanindividuals AT mariaelenamedinamora genomewideassociationstudyofpsychiatricandsubstanceusecomorbidityinmexicanindividuals AT humbertonicolini genomewideassociationstudyofpsychiatricandsubstanceusecomorbidityinmexicanindividuals
_version_	1718381849788547072

Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals

Ejemplares similares