Seroprevalence of anti-SARS-CoV-2 antibodies and risk factors among healthy blood donors in Luanda, Angola
Abstract Background SARS-CoV-2 emerged in China and spread throughout the world due to its rapid transmission. The exposure rate in the healthy population is unknown, mainly in resource-limited countries. Herein, we estimated the seroprevalence of anti-SARS-CoV-2 antibodies and risk factors among bl...
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oai:doaj.org-article:5d0f0e7be8a441f18d70f967995cdce92021-11-08T11:18:39ZSeroprevalence of anti-SARS-CoV-2 antibodies and risk factors among healthy blood donors in Luanda, Angola10.1186/s12879-021-06814-01471-2334https://doaj.org/article/5d0f0e7be8a441f18d70f967995cdce92021-11-01T00:00:00Zhttps://doi.org/10.1186/s12879-021-06814-0https://doaj.org/toc/1471-2334Abstract Background SARS-CoV-2 emerged in China and spread throughout the world due to its rapid transmission. The exposure rate in the healthy population is unknown, mainly in resource-limited countries. Herein, we estimated the seroprevalence of anti-SARS-CoV-2 antibodies and risk factors among blood donors in Luanda, the capital city of Angola. Methods This was a retrospective study conducted with 343 blood donors. Chi-square and logistic regression were calculated to predict the independent variable for SARS-CoV-2 infection and deemed significant when p < 0.05. Results Seroprevalence of anti-SARS-CoV-2 was 4.7%. Positivity rates varied to age groups (3.5–14.3%), gender (0–5%), area of residence (3.1–.6%), educational level (5.1–10.2%), occupation (4.4–7.7%), and the blood donor category (2.0–5.1%). Past and recent infections were detected in 3.2% and 1.5%, respectively. Blood donors under the age of 20 years (OR: 4.58, p = 0.241) and from non-urbanized areas (OR: 1.86, p = 0.293) presented a high risk related to infection. The infection was higher in blood group A and lower in blood group O. The risk of SARS-CoV-2 infection has increased from January 2020 (OR: 0.03, p = 0.001) to August 2020 (OR: 0.57, p = 0.426). Conclusions We provide an estimate of the exposure of healthy blood donors in Luanda. Also, we detected anti-SARS-CoV-2 in January 2020, indicating that the SARS-CoV-2 could have been imported during the first month of 2020. Further studies should be performed to assess the exposure rate in different groups from Angola.Cruz S. SebastiãoManuela GalangueCelestina GastonRui Van-DunenJoltim QuivinjaEmiliana LunbungululoDomingos AlfredoAlberto SozinhoAlice TeixeiraEunice ManicoDeodete MachadoAntónio MateusZinga DavidJoana PaixãoZoraima NetoJocelyne Neto de VasconcelosJoana MoraisBMCarticleSeroprevalenceSARS-CoV-2COVID-19Blood donorsLuandaAngolaInfectious and parasitic diseasesRC109-216ENBMC Infectious Diseases, Vol 21, Iss 1, Pp 1-10 (2021) |
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Seroprevalence SARS-CoV-2 COVID-19 Blood donors Luanda Angola Infectious and parasitic diseases RC109-216 |
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Seroprevalence SARS-CoV-2 COVID-19 Blood donors Luanda Angola Infectious and parasitic diseases RC109-216 Cruz S. Sebastião Manuela Galangue Celestina Gaston Rui Van-Dunen Joltim Quivinja Emiliana Lunbungululo Domingos Alfredo Alberto Sozinho Alice Teixeira Eunice Manico Deodete Machado António Mateus Zinga David Joana Paixão Zoraima Neto Jocelyne Neto de Vasconcelos Joana Morais Seroprevalence of anti-SARS-CoV-2 antibodies and risk factors among healthy blood donors in Luanda, Angola |
| description |
Abstract Background SARS-CoV-2 emerged in China and spread throughout the world due to its rapid transmission. The exposure rate in the healthy population is unknown, mainly in resource-limited countries. Herein, we estimated the seroprevalence of anti-SARS-CoV-2 antibodies and risk factors among blood donors in Luanda, the capital city of Angola. Methods This was a retrospective study conducted with 343 blood donors. Chi-square and logistic regression were calculated to predict the independent variable for SARS-CoV-2 infection and deemed significant when p < 0.05. Results Seroprevalence of anti-SARS-CoV-2 was 4.7%. Positivity rates varied to age groups (3.5–14.3%), gender (0–5%), area of residence (3.1–.6%), educational level (5.1–10.2%), occupation (4.4–7.7%), and the blood donor category (2.0–5.1%). Past and recent infections were detected in 3.2% and 1.5%, respectively. Blood donors under the age of 20 years (OR: 4.58, p = 0.241) and from non-urbanized areas (OR: 1.86, p = 0.293) presented a high risk related to infection. The infection was higher in blood group A and lower in blood group O. The risk of SARS-CoV-2 infection has increased from January 2020 (OR: 0.03, p = 0.001) to August 2020 (OR: 0.57, p = 0.426). Conclusions We provide an estimate of the exposure of healthy blood donors in Luanda. Also, we detected anti-SARS-CoV-2 in January 2020, indicating that the SARS-CoV-2 could have been imported during the first month of 2020. Further studies should be performed to assess the exposure rate in different groups from Angola. |
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article |
| author |
Cruz S. Sebastião Manuela Galangue Celestina Gaston Rui Van-Dunen Joltim Quivinja Emiliana Lunbungululo Domingos Alfredo Alberto Sozinho Alice Teixeira Eunice Manico Deodete Machado António Mateus Zinga David Joana Paixão Zoraima Neto Jocelyne Neto de Vasconcelos Joana Morais |
| author_facet |
Cruz S. Sebastião Manuela Galangue Celestina Gaston Rui Van-Dunen Joltim Quivinja Emiliana Lunbungululo Domingos Alfredo Alberto Sozinho Alice Teixeira Eunice Manico Deodete Machado António Mateus Zinga David Joana Paixão Zoraima Neto Jocelyne Neto de Vasconcelos Joana Morais |
| author_sort |
Cruz S. Sebastião |
| title |
Seroprevalence of anti-SARS-CoV-2 antibodies and risk factors among healthy blood donors in Luanda, Angola |
| title_short |
Seroprevalence of anti-SARS-CoV-2 antibodies and risk factors among healthy blood donors in Luanda, Angola |
| title_full |
Seroprevalence of anti-SARS-CoV-2 antibodies and risk factors among healthy blood donors in Luanda, Angola |
| title_fullStr |
Seroprevalence of anti-SARS-CoV-2 antibodies and risk factors among healthy blood donors in Luanda, Angola |
| title_full_unstemmed |
Seroprevalence of anti-SARS-CoV-2 antibodies and risk factors among healthy blood donors in Luanda, Angola |
| title_sort |
seroprevalence of anti-sars-cov-2 antibodies and risk factors among healthy blood donors in luanda, angola |
| publisher |
BMC |
| publishDate |
2021 |
| url |
https://doaj.org/article/5d0f0e7be8a441f18d70f967995cdce9 |
| work_keys_str_mv |
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1718442240827719680 |