Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis

The mechanisms controlling irreversible cell cycle exit in cerebellar granule progenitors (GCPs) have not been fully elucidated. Here, the authors performed RNA-sequencing of GCPs exiting the cell cycle to identify downregulation of Brd4 activity as an early event during cell cycle exit which subseq...

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Autores principales:	Clara Penas, Marie E. Maloof, Vasileios Stathias, Jun Long, Sze Kiat Tan, Jose Mier, Yin Fang, Camilo Valdes, Jezabel Rodriguez-Blanco, Cheng-Ming Chiang, David J. Robbins, Daniel J. Liebl, Jae K. Lee, Mary E. Hatten, Jennifer Clarke, Nagi G. Ayad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5d102d486ad049ca91e993219a553e49
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spelling	oai:doaj.org-article:5d102d486ad049ca91e993219a553e492021-12-02T17:32:24ZTime series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis10.1038/s41467-019-10799-52041-1723https://doaj.org/article/5d102d486ad049ca91e993219a553e492019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10799-5https://doaj.org/toc/2041-1723The mechanisms controlling irreversible cell cycle exit in cerebellar granule progenitors (GCPs) have not been fully elucidated. Here, the authors performed RNA-sequencing of GCPs exiting the cell cycle to identify downregulation of Brd4 activity as an early event during cell cycle exit which subsequently regulates Shh activity and is needed for proper cerebellar developmentClara PenasMarie E. MaloofVasileios StathiasJun LongSze Kiat TanJose MierYin FangCamilo ValdesJezabel Rodriguez-BlancoCheng-Ming ChiangDavid J. RobbinsDaniel J. LieblJae K. LeeMary E. HattenJennifer ClarkeNagi G. AyadNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Clara Penas Marie E. Maloof Vasileios Stathias Jun Long Sze Kiat Tan Jose Mier Yin Fang Camilo Valdes Jezabel Rodriguez-Blanco Cheng-Ming Chiang David J. Robbins Daniel J. Liebl Jae K. Lee Mary E. Hatten Jennifer Clarke Nagi G. Ayad Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis
description	The mechanisms controlling irreversible cell cycle exit in cerebellar granule progenitors (GCPs) have not been fully elucidated. Here, the authors performed RNA-sequencing of GCPs exiting the cell cycle to identify downregulation of Brd4 activity as an early event during cell cycle exit which subsequently regulates Shh activity and is needed for proper cerebellar development
format	article
author	Clara Penas Marie E. Maloof Vasileios Stathias Jun Long Sze Kiat Tan Jose Mier Yin Fang Camilo Valdes Jezabel Rodriguez-Blanco Cheng-Ming Chiang David J. Robbins Daniel J. Liebl Jae K. Lee Mary E. Hatten Jennifer Clarke Nagi G. Ayad
author_facet	Clara Penas Marie E. Maloof Vasileios Stathias Jun Long Sze Kiat Tan Jose Mier Yin Fang Camilo Valdes Jezabel Rodriguez-Blanco Cheng-Ming Chiang David J. Robbins Daniel J. Liebl Jae K. Lee Mary E. Hatten Jennifer Clarke Nagi G. Ayad
author_sort	Clara Penas
title	Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis
title_short	Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis
title_full	Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis
title_fullStr	Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis
title_full_unstemmed	Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis
title_sort	time series modeling of cell cycle exit identifies brd4 dependent regulation of cerebellar neurogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5d102d486ad049ca91e993219a553e49
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Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis

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